Lessons of Centralized Procurement of Domestic Office and Antivirus Software in 2019–2020 Years

The article shows effects assessment of procurement process centralisation and centralized purchasing; describes case of centralized procurement of domestic office and antivirus software for federal government bodies; explain advantages and disadvantages; forms recommendations for future centralized procurement.

Therapeutic Effect of Superficial Cryotherapy versus Intralesional Corticosteroids injection in Alopecia Areata

Alopecia areata, one or more round bald patches appear suddenly, most often on the scalp. It can affect males and females at any age. It starts in childhood in about 50%, and before the age of 40 years in 80%. The exact mechanism is not yet understood. There is not yet any reliable cure for alopecia areata. Several topical treatments used for alopecia areata are reported to result in temporary improvement in some people. Their role and efficacy are unknown. Injections of triamcinolone acetonide 2.5–10 mg/ml into patchy scalp, its efficacy is temporary. Oral and pulse intravenous steroids in high dose can lead to temporary regrowth of hair. The sensitisers diphenylcyclopropenone provoke hair growth in treated areas Now, superficial cryotheray is introduced as a possible treatment for Alopecia Areata. With minimial side effects and being less painful. So, this study clarifies the therapeutic efficacy and safety of superficial cryotherapy for treatment of patchy Alopecia areata. Aim of the study The aim of the study is to evaluate and compare the efficacy and safety of Superficial Cryotherapy and Intralesional corticosteroids in the treatment of patchy Alopecia Areata. Patients and methods study included 20 patients complaining of Alopecia Areata. 3 patches of scalp alopecia areata will be randomly subjected to either superficial cryotherapy twice monthly for 3 months (3 cycles, 2-3 seconds) or intralesional steroid injections once monthly for 3 months (triaminoclone acetonide 1:7, 1ml) or intralesional saline (1 ml). Assessment for the response to treatment will be done at one month and three month following treatment by digital photography and by phototrichogram by comparing number of Terminal, and vellus and hair thickness, Also assessment for side effects of therapy will be done. Results Patients treated with TCA showed statistically significant high response compared to patients treated with cryotherapy. Also, side effects assessment showed minimal side effects with treatment with TCA compared to cryotherapy. Conclusion TCA treatment of alopecia areata is much tolerable than treatment with cryotherapy with also better response rates.

Guidance for analytical methods to cumulative effects assessment for terrestrial species

Landscapes in Canada are undergoing change due to resource and land use stressors and climate stressors. Understanding the cumulative effects of these stressors is challenging because of the complexity of ecosystems, the variability of stressors, and species response to individual or multiple stressors. A key challenge within the field of cumulative effects assessment (CEA) is guidance that describes and evaluates analytical methods. In this review we discuss four broad categories of methods with current or potential use for project-based and effects-based CEA for species in terrestrial systems: (i) qualitative review, (ii) habitat supply models, (iii) empirical species–stressor models, and (iv) decision support models. We describe each method and provide examples, highlight advantages and limitations, identify how methods address key science-based CEA questions, and provide direction on when and why to use specific CEA methods. Empirical species–stressor models and decision support models are the only analytical approaches that provide answers to many science-based CEA questions including how multiple stressors combine to affect an individual species and the certainty of multiple stressor effects. We provide recommendations for using one or more methods as complementary building blocks to fill data gaps, improve understanding and communication, engage diverse partner groups, and increase the quality and credibility of the CEA. Our review supports a move toward regional scale, effects-based CEA where partner collaboration to design, implement, and analyze comprehensive assessments of multiple stressors will (i) expand our knowledge of terrestrial species response to stressors and (ii) inform best management practices for resource industries and conservation and management actions for land managers.