Thioacetamide-induced liver regeneration involves the expression of cyclooxygenase 2 and nitric oxide synthase 2 in hepatocytes

2004 ◽  
Vol 40 (6) ◽  
pp. 963-970 ◽  
Author(s):  
A FERNANDEZMARTINEZ
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Liver Regeneration ◽  
Cyclooxygenase 2 ◽  
Nitric Oxide Synthase 2 ◽  
Oxide Synthase

Requirement of nuclear factor kappaB for the constitutive expression of nitric oxide synthase-2 and cyclooxygenase-2 in rat trophoblasts

1999 ◽  
Vol 112 (18) ◽  
pp. 3147-3155
Author(s):  
N.A. Callejas ◽  
M. Casado ◽  
L. Bosca ◽  
P. Martin-Sanz
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Cyclooxygenase 2 ◽  
Nuclear Factor Kappab ◽  
Mrna Levels ◽  
Nuclear Factor ◽  
Cox 2 ◽  
Nf Kappab ◽  
Nitric Oxide Synthase 2 ◽  
Oxide Synthase

Recently isolated trophoblasts express nitric oxide synthase 2 (NOS-2) and cyclooxygenase 2 (COX-2), decreasing the levels of the corresponding mRNAs when the cells were maintained in culture. The sustained expression of COX-2 and NOS-2 in trophoblasts was dependent on the activation of nuclear factor kappaB (NF-kappaB) since proteasome inhibitors and antioxidants that abrogated NF-kappaB activity suppressed the induction of both genes. The time-dependent fall of the mRNA levels of NOS-2 and COX-2 paralleled the inhibition of NF-kappaB, determined by electrophoretic mobility shift assays, and the increase of the IkappaBalpha and IkappaBbeta inhibitory proteins. Isolated trophoblasts synthesized reactive oxygen intermediates (ROI), a process impaired after culturing the cells, and that might be involved in the NF-kappaB activation process. Moreover, treatment of recently isolated cells with ROI scavengers suppressed the expression of COX-2 and NOS-2. Challenge of trophoblasts with interleukin-1beta up-regulated the expression of both proteins, an effect that was potentiated by lipopolysaccharide. These results indicate that the physiological expression of NOS-2 and COX-2 in trophoblasts involves a sustained activation of NF-kappaB which inhibition abrogates the inducibility of both genes.

A novel indazolo-triazolo-benzotriazepine exerts anti-inflammatory effects by inhibition of cyclooxygenase-2 activity and nitric oxide synthase-2 expression

2003 ◽  
Vol 368 (1) ◽  
pp. 26-32 ◽  
Author(s):  
Patricia Fern�ndez ◽  
M. Isabel Guill�n ◽  
Amalia Ubeda ◽  
Pablo L�pez-Cremades ◽  
Enrique Aller ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Cyclooxygenase 2 ◽  
Anti Inflammatory ◽  
Nitric Oxide Synthase 2 ◽  
Oxide Synthase

Relationship between cyclooxygenase-2 and nitric oxide synthase-2 in rat cortex after stress

2003 ◽  
Vol 18 (6) ◽  
pp. 1701-1705 ◽  
Author(s):  
Jose L. M. Madrigal ◽  
Borja Garcia-Bueno ◽  
Maria A. Moro ◽  
Ignacio Lizasoain ◽  
Pedro Lorenzo ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Cyclooxygenase 2 ◽  
Rat Cortex ◽  
Nitric Oxide Synthase 2 ◽  
Oxide Synthase

Increase in cyclooxygenase-2 and nitric oxide–synthase-2 mRNAs in pouchitis without modification of inducible isoenzyme heme-oxygenase-1

2001 ◽  
Vol 96 (7) ◽  
pp. 2129-2136 ◽  
Author(s):  
Antony Leplingard ◽  
Maud Brung-Lefebvre ◽  
Claire Guédon ◽  
Guillaume Savoye ◽  
Pierre Déchelotte ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Heme Oxygenase ◽  
Cyclooxygenase 2 ◽  
Heme Oxygenase 1 ◽  
Nitric Oxide Synthase 2 ◽  
Oxide Synthase

Role of nitric oxide synthesized by nitric oxide synthase 2 in liver regeneration

2008 ◽  
Vol 28 (6) ◽  
pp. 865-877 ◽  
Author(s):  
Takafumi Kumamoto ◽  
Shinji Togo ◽  
Atsushi Ishibe ◽  
Daisuke Morioka ◽  
Kazuteru Watanabe ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Liver Regeneration ◽  
Nitric Oxide Synthase 2 ◽  
Oxide Synthase
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