scholarly journals Design of a prospective observational survey on landiolol in atrial fibrillation/atrial flutter patients with chronic heart failure – AF-CHF landiolol survey

2015 ◽  
Vol 66 (1) ◽  
pp. 69-72 ◽  
Author(s):  
Takeshi Yamashita ◽  
Takeshi Saitoh ◽  
Masaru Matsushita

Introduction. Radiofrequency ablation (RFA) is today the method of choice for the ineffective medical treatment of atrial fibrillation (AF), but its course is often complicated by comorbid pathology. The predicted great impact of these nosologies on the effectiveness of radiofrequency ablation of the arrhythmia substrate requires additional study before RFA. Objectives – to analyze the clinical characteristics of patients with isolated atrial fibrillation and combination with of atrial fibrillation with atrial flutter (AF + AFib) that underwent radiofrequency ablation of the arrhythmia substrate. Materials and methods. 84 patients aged 65 ± 9 (82.3 % of men) were examined, who underwent RFA of the arrhythmia substrate: cavo-tricuspid isthmus (CTI) or combined with pulmonary veins isolation (CTI + PV) strategy for patients with AFib. Before radiofrequency ablation, the following clinical indicators were assessed: forms of AF + AFib, the presence of chronic heart failure (CHF) and functional classes (FC) according to NYHA classification, the forms of chronic coronary syndromes (CCS): postinfarction cardiosclerosis, syndrome-X, functional classes of stable angina (SA), stages of arterial hypertension (AH), the presence of type 2 diabetes or stroke in the anamnesis. Results. Radiofrequency ablation of isolated atrial fibrillation was more often performed for persistent arrhythmia in patients with stable angina III FC, arterial hypertension stage 2 and 3, radiofrequency ablation of combination of atrial fibrillation with atrial flutter – equally often for persistent or paroxysmal form in patients with SA I and II class, AH stage 2 and 3; in both cases patients with chronic heart failure II and III FC more often needed radiofrequency ablation of the arrhythmia substrate. Conclusions. Given the lack of correlation between clinical and demographic characteristics, it is advisable to continue studying their prognostic effect on the course of comorbid pathology and treatment of patients after radiofrequency ablation of the arrhythmia substrate of atrial fibrillation and combination of atrial fibrillation with atrial flutter.


2013 ◽  
Vol 61 (10) ◽  
pp. E735
Author(s):  
Savina Nodari ◽  
Marco Triggiani ◽  
Laura Lupi ◽  
Alessandra Manerba ◽  
Giuseppe Milesi ◽  
...  

Author(s):  
T. V. Zolotarova ◽  

Atrial fibrillation (AF) directly leads to a cognitive function decline regardless of the cerebrovascular fatal events, but it is unclear whether the sinus rhythm restoration and reducing the AF burden can reduce the rate of this decreasement. Data on the effect of radiofrequency ablation on patients’ cognitive functions are conflicting and need to be studied. The aim of the study was to evaluate the prognostic value of atrial fibrillation radiofrequency catheter ablation on cognitive functions in patients with chronic heart failure with preserved left ventricular ejection fraction. The impact of AF radiofrequency catheter ablation on cognitive function in 136 patients (mean age 59.7 ± 8.6 years) with chronic heart failure with preserved left ventricular ejection fraction and compared with 58 patients in the control group (58.2 ± 8.1 years), which did not perform ablation and continued the tactics of drug antiarrhythmic therapy was investigated. Cognitive function was assessed using the Montreal Cognitive Test (MoCA) at the enrollment stage and 2 years follow-up. Decreased cognitive function was defined as a MoCA test score < 26 points, cognitive impairment < 23 points. Two years after the intervention, there was a positive dynamics (baseline MoCA test — 25,1 ± 2,48, 2-year follow-up — 26,51 ± 2,33, p < 0,001) in the ablation group and negative in the control group (25,47 ± 2,85 and 24,57 ± 3,61, respectively, p < 0,001). Pre-ablation cognitive impairment was significantly associated with improved cognitive function 2 years after AF ablation according to polynomial regression analysis. The obtained data suggest a probable positive effect of AF radiofrequency ablation on cognitive functions in patients with preserved left ventricular ejection fraction.


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