scholarly journals Relationship between yellow plaque grade and tissue protrusion after stent implantation: A coronary angioscopy study

2017 ◽  
Vol 70 (4) ◽  
pp. 342-345 ◽  
Author(s):  
Toru Miyoshi ◽  
Hideo Kawakami ◽  
Fumiyasu Seike ◽  
Akira Oshita ◽  
Hiroshi Matsuoka
Keyword(s):  
Stent Implantation ◽  
Yellow Plaque ◽  
Coronary Angioscopy

Optical coherence tomography and coronary angioscopy assessment of healed vulnerable plaque components in patients with coronary artery lesions undergoing elective percutaneous coronary intervention

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
S Kimura ◽  
K Hara ◽  
M Ohmori ◽  
R Tateishi ◽  
T Kaneda ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Coronary Artery ◽  
Vulnerable Plaque ◽  
Multivariate Logistic Regression Analysis ◽  
Low Grade ◽  
Optical Coherence ◽  
Coronary Artery Lesions ◽  
Coronary Syndrome ◽  
Yellow Plaque ◽  
Coronary Angioscopy

Abstract Background Many vulnerable plaques would progress without clinical events and might result in healed plaques (HPs). Histopathological or intracoronary image assessment of HPs has been reported. However, the morphological characteristics of HPs remain unclear yet. Purpose We sought to assess the healed vulnerable plaque components in patients with coronary artery lesions using optical coherence tomography (OCT) and coronary angioscopy (CAS). Methods We enrolled 47 patients with 50 native coronary artery lesions with angiographical severe stenosis (>90% diameter-stenosis) and without severe calcification (36 lesions with stable angina pectoris (SAP) and 14 acute coronary syndrome (ACS)) undergoing pre-intervention OCT and CAS. HPs was defined as layered phenotype on OCT. Lesion morphologies and plaque characteristics in lesions with HPs were assessed using OCT and CAS images. Results HPs were observed in 27 lesions (54.0%) and their prevalence were similar among each clinical status (SAP 52.8%, ACS 57.1%, p=1.00). Lesions with HPs had higher prevalence of OCT-macrophage (88.0% vs. 52.0%, p=0.01), CAS-red thrombus (88.8% vs. 52.2%, p=0.004) and CAS-low grade-yellow plaque (grade 1) (55.6% vs. 21.7%, p=0.02) than those without. SAP lesions with HPs had higher prevalence of CAS-yellow plaque (35.3% vs. 5.9%, p=0.09) and OCT-thin-cap fibroatheroma (42.1% vs. 5.9%, p=0.04) than SAP without HPs. ACS lesions with HPs had less CAS-red thrombus (0.0% vs. 50.0%, p=0.03) and OCT-plaque rupture (12.5% vs. 66.7%, p=0.04) than ACS without HPs. Multivariate logistic regression analysis revealed that OCT-macrophages (odds ratio (OR): 6.65, 95%-confidence intervals: 1.07–41.5, p=0.043), CAS-red thrombus (OR 8.77, 95% CI 1.33–57.8, p=0.02), and low grade-yellow plaque (OR 13.05, 95% CI 1.97–86.5, p=0.008) were independently related with the existence of HPs lesions. Combination of these 3 factors showed a high predictive value of OCT-HPs lesions (90.9%). Conclusions HPs lesions showed the lower lesion vulnerability than common ACS lesions but had more intraplaque inflammatory condition compared with common SAP lesions. Combined CAS and OCT examination might be useful to clarify the plaque components of HPs lesions in vivo, leading to help us understand the clinical significance of HPs. Funding Acknowledgement Type of funding source: None

Abstract 13714: Clinical Utility of the Triglyceride-glucose Index Which is a Novel Marker of Insulin Resistance for Predicting the Neointimal Vulnerability After Everolimus-eluting Stent Implantation

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Naotaka Akutsu ◽  
Riku Arai ◽  
Daisuke Fukamachi ◽  
Yasuo Okumura
Keyword(s):  
Insulin Resistance ◽  
Stent Implantation ◽  
Tyg Index ◽  
Index Group ◽  
Triglyceride Glucose Index ◽  
Coronary Angioscopy ◽  
High Insulin ◽  
Grade 3 ◽  
The Relationship

Introduction: Insulin resistance has been recognized as the cause of cardiovascular disease, but little is known about the influence of insulin resistance to neointimal characteristics after stent implantation. Hypothesis: The high triglyceride-glucose index (TyG index) has been reported to indirectly represent a high insulin resistance. It was hypothesized that in-stent neointimal characteristics in the high TyG index patients may be unstable more than the low TyG index patients. Methods: In 100 patients, we investigated the relationship between the neointimal characteristics and the TyG index using coronary angioscopy (CAS) and optical coherence tomography (OCT) during follow-up angiography after stent implantation. We divided into 2 groups according to the median value of TyG index (8.8). Results: The high TyG index group (n=48) had the higher yellow grade and the higher prevalence of yellow grade 3 by CAS than the low TyG index group (n=52). The prevalence of heterogeneous and layered patterns were more often observed by OCT in the high TyG index group than in the low TyG index group (Figure). Conclusions: The high TyG index strongly associated with neointimal vulnerability evaluating by CAS and OCT. The TyG index can be a useful predictor for the neointimal vulnerability after stent implantation.

scholarly journals Different vascular healing process between bioabsorbable polymer-coated everolimus-eluting stents versus bioresorbable vascular scaffolds via optical coherence tomography and coronary angioscopy (the ENHANCE study: ENdothelial Healing Assessment with Novel Coronary tEchnology)

2019 ◽  
Vol 35 (4) ◽  
pp. 463-473 ◽  
Author(s):  
Wan Azman Wan Ahmad ◽  
Takaharu Nakayoshi ◽  
Ahmad Syadi Mahmood Zuhdi ◽  
Muhammad Dzafir Ismail ◽  
Imran Zainal Abidin ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Healing Process ◽  
Coronary Vessels ◽  
Optical Coherence ◽  
Bioabsorbable Polymer ◽  
Neointimal Thickness ◽  
Yellow Plaque ◽  
Coronary Angioscopy ◽  
Vascular Scaffolds ◽  
Bioresorbable Vascular Scaffolds

Abstract Recent clinical trials have raised concerns about the safety and efficacy of ABSORB™ bioresorbable vascular scaffolds (BVS). The difference in the vascular healing process between SYNERGY™ bioabsorbable polymer-coated everolimus-eluting stents (BP-EES) and BVS remains unclear. The aim of the ENHANCE study was to compare vascular healing on BP-EES versus BVS by optical coherence tomography (OCT) and coronary angioscopy (CAS) at 4- and 12-month follow-ups. This is a prospective, non-randomized, single center clinical trial. Thirteen eligible patients with multivessel disease were enrolled. BP-EES and BVS were simultaneously implanted in the same patients, but in different coronary vessels. Imaging follow-up with both OCT and CAS was completed in 11 patients at 12 months. Neointimal coverage rates were similar between the two groups based on OCT measurements. The neointimal thickness of BP-EES was significantly thicker at the 12th month than at the 4th month, whereas the neointimal thickness of BVS did not change between the measurements taken at the 4th and 12th month. Existence of intra-stent thrombus was significantly higher in the BVS group, compared to the BP-EES group. On the other hand, CAS revealed that red-thrombi and yellow-plaque were more frequently observed in BVS at 4 months and up to 12-month follow-ups than in BP-EES. These findings suggested that the evidence of instability remained up to 12 months in the vascular healing with BVS, compared to that with BP-EES. Vascular healing of the stented wall was recognized at the very early phase after BP-EES implantation. However, vascular healing with BVS was still incomplete after 12 months.

Extreme late-phase observation using coronary angioscopy until 7 years after sirolimus-eluting stent implantation

2016 ◽  
Vol 27 (1) ◽  
pp. 29-33 ◽  
Author(s):  
Tetsuro Shimura ◽  
Masanori Yamamoto ◽  
Masamichi Takano ◽  
Kentaro Okamatsu ◽  
Shigenobu Inami ◽  
...  
Keyword(s):  
Stent Implantation ◽  
Late Phase ◽  
Phase Observation ◽  
Coronary Angioscopy ◽  
Sirolimus Eluting Stent

Very Long-term Evaluation by Coronary Angioscopy after Sirolimus-eluting Stent Implantation

2013 ◽  
Vol 111 (7) ◽  
pp. 85B
Author(s):  
Yusuke Katayama ◽  
Keiji Yamada ◽  
Kota Okabe ◽  
Takashi Fujiwara ◽  
Takashi Miki ◽  
...  
Keyword(s):  
Stent Implantation ◽  
Coronary Angioscopy ◽  
Term Evaluation ◽  
Sirolimus Eluting Stent

scholarly journals Mobilization of progenitor cells and vessel healing after implantation of SYNERGY in acute coronary syndrome

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Masashi Sakuma ◽  
Setsu Nishino ◽  
Takahisa Nasuno ◽  
Michiya Kageyama ◽  
Michiaki Tokura ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Acute Coronary Syndrome ◽  
Progenitor Cells ◽  
Stent Implantation ◽  
Healing Process ◽  
Coronary Syndrome ◽  
Neointimal Thickness ◽  
Coronary Stent Implantation ◽  
Coronary Angioscopy ◽  
Neointimal Coverage

AbstractThis study was aimed to compare the vascular healing process of a SYNERGY stent with that of a PROMUS PREMIER stent in patients with acute coronary syndrome (ACS). In 71 patients with ACS, undergoing coronary stent implantation using the SYNERGY stent (n = 52) or PROMUS PREMIER stent (n = 19), we measured circulating CD34+/CD133+/CD45null cells and CD34+/KDR+ cells and observed vascular healing at the stented sites using optical coherence tomography (OCT) and coronary angioscopy. On the day 7, circulating CD34+/CD133+/CD45null cells increased in SYNERGY group (P < 0.0001), while it did not change in PROMUS group. The CD34+/KDR+ cells also increased in SYNERGY group (P < 0.0001) but less significantly in the PROMUS group (P < 0.05). The OCT-based neointimal thickness (P < 0.0005) and neointimal coverage rate (P < 0.05) at 12 months were greater in SYNERGY group, compared with PROMUS group. The coronary angioscopy-based neointimal coverage grade at 12 months was also greater in SYNERGY group (P < 0.001). In overall patients, the change in CD34+/KDR+ cells on the day 7 correlated with the OCT-based neointimal thickness at 12 months (R = 0.288, P < 0.05). SYNERGY stent seems to have potential advantages over PROMUS PREMIER stent for ACS patients in terms of vascular healing process at the stented sites.

scholarly journals In Vivo Evaluation of Tissue Protrusion by Using Optical Coherence Tomography and Coronary Angioscopy Immediately After Stent Implantation

2020 ◽  
Vol 84 (12) ◽  
pp. 2235-2243
Author(s):  
Shunsuke Sakai ◽  
Akira Sato ◽  
Tomoya Hoshi ◽  
Daigo Hiraya ◽  
Hiroaki Watabe ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Stent Implantation ◽  
Optical Coherence ◽  
In Vivo Evaluation ◽  
Coronary Angioscopy
Sign in / Sign up

Export Citation Format

Share Document