A conservative point mutation in a dynamic antigen-binding loop of human immunoglobulin λ6 light chain promotes pathologic amyloid formation

2021 ◽  
pp. 167310
Author(s):  
Daniele Peterle ◽  
Elena S. Klimtchuk ◽  
Thomas E. Wales ◽  
Florian Georgescauld ◽  
Lawreen H. Connors ◽  
...  
Keyword(s):  
Point Mutation ◽  
Light Chain ◽  
Human Immunoglobulin ◽  
Antigen Binding ◽  
Amyloid Formation ◽  
Binding Loop

scholarly journals Author response: Fatal amyloid formation in a patient’s antibody light chain is caused by a single point mutation

2020 ◽  
Author(s):  
Pamina Kazman ◽  
Marie-Theres Vielberg ◽  
María Daniela Pulido Cendales ◽  
Lioba Hunziger ◽  
Benedikt Weber ◽  
...  
Keyword(s):  
Point Mutation ◽  
Light Chain ◽  
Single Point ◽  
Author Response ◽  
Single Point Mutation ◽  
Amyloid Formation

A monoclonal antibody Hy20-54-16-3L to lambda (λ) light chain of human immunoglobulin reacts with amyloid in Alzheimer's disease brain

1990 ◽  
Vol 117 (1-2) ◽  
pp. 62-67 ◽  
Author(s):  
Fuyuki Kametani ◽  
Kikuko Tanaka ◽  
Maroto Sato ◽  
Seiichi Haga ◽  
Takashi Saitoh ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Monoclonal Antibody ◽  
Light Chain ◽  
Human Immunoglobulin ◽  
Λ Light Chain

Scarcity of λ1 B cells in mice with a single point mutation in Cλ1 is due to a low BCR signal caused by misfolded lambda1 light chain

2007 ◽  
Vol 44 (6) ◽  
pp. 1417-1428 ◽  
Author(s):  
Veronica V. Volgina ◽  
Tianhe Sun ◽  
Grazyna Bozek ◽  
Terence E. Martin ◽  
Ursula Storb
Keyword(s):  
B Cells ◽  
Point Mutation ◽  
Light Chain ◽  
Single Point ◽  
Single Point Mutation

scholarly journals Differential Effects on Light Chain Amyloid Formation Depend on Mutations and Type of Glycosaminoglycans

2015 ◽  
Vol 108 (2) ◽  
pp. 516a
Author(s):  
Luis M. Blancas-Mejia ◽  
Jared A. Hammernik ◽  
Marta Marin-Argany ◽  
Marina Ramirez-Alvarado
Keyword(s):  
Light Chain ◽  
Amyloid Formation ◽  
Differential Effects

scholarly journals Differential Effects on Light Chain Amyloid Formation Depend on Mutations and Type of Glycosaminoglycans

2014 ◽  
Vol 290 (8) ◽  
pp. 4953-4965 ◽  
Author(s):  
Luis M. Blancas-Mejía ◽  
Jared Hammernik ◽  
Marta Marin-Argany ◽  
Marina Ramirez-Alvarado
Keyword(s):  
Light Chain ◽  
Amyloid Formation ◽  
Differential Effects
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