Comparison of the clinical efficacy between tigecycline plus extended-infusion imipenem and sulbactam plus imipenem against ventilator-associated pneumonia with pneumonic extensively drug-resistant Acinetobacter baumannii bacteremia, and correlation of clinical efficacy with in vitro synergy tests

ABSTRACT Acinetobacter baumannii is responsible for 10% of all nosocomial infections and has >50% mortality rates when causing ventilator-associated pneumonia. In this proof-of-concept study, we evaluated SPR741, an antibiotic adjuvant that permeabilizes the Gram-negative membrane, in combination with rifampin against AB5075, an extensively drug-resistant (XDR) A. baumannii strain. In standard in vitro assays and in a murine pulmonary model, we found that this drug combination can significantly reduce bacterial burden and promote animal survival despite an aggressive infection.

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Correlation of Checkerboard Synergy Testing with Time-Kill Analysis and Clinical Outcomes of Extensively Drug-Resistant Acinetobacter baumannii Respiratory Infections

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.00981-16 ◽

2016 ◽

Vol 60 (11) ◽

pp. 6892-6895 ◽

Cited By ~ 12

Author(s):

Derek N. Bremmer ◽

Karri A. Bauer ◽

Stephanie M. Pouch ◽

Keelie Thomas ◽

Debra Smith ◽

...

Keyword(s):

Acinetobacter Baumannii ◽

Clinical Outcomes ◽

Clinical Utility ◽

Respiratory Infections ◽

Drug Resistant ◽

Content Type ◽

Extensively Drug Resistant ◽

Time Kill ◽

Synergy Testing

ABSTRACTWe tested 76 extensively drug-resistant (XDR)Acinetobacter baumanniiisolates by the checkerboard method using only wells containing serum-achievable concentrations (SACs) of drugs. Checkerboard results were correlated by time-kill assay and clinical outcomes. Minocycline-colistin was the best combinationin vitro, as it inhibited growth in one or more SAC wells in all isolates. Patients who received a combination that inhibited growth in one or more SAC wells demonstrated better microbiological clearance than those who did not (88% versus 30%;P= 0.025). The checkerboard platform may have clinical utility for XDRA. baumanniiinfections.

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Acinetobacter baumannii Ventilator-Associated Pneumonia: Clinical Efficacy of Combined Antimicrobial Therapy and in vitro Drug Sensitivity Test Results

Frontiers in Pharmacology ◽

10.3389/fphar.2019.00092 ◽

2019 ◽

Vol 10 ◽

Cited By ~ 5

Author(s):

Yuqin Huang ◽

Quan Zhou ◽

Wenguo Wang ◽

Qiang Huang ◽

Juan Liao ◽

...

Keyword(s):

Acinetobacter Baumannii ◽

Clinical Efficacy ◽

Antimicrobial Therapy ◽

Drug Sensitivity ◽

Sensitivity Test ◽

Ventilator Associated Pneumonia ◽

Test Results ◽

Drug Sensitivity Test

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In Vitro Antimicrobial Activity of Dermcidin-1L Against Extensively-Drug-Resistant and Pandrug-Resistant Acinetobacter baumannii

Jundishapur Journal of Microbiology ◽

10.5812/jjm.13201 ◽

2017 ◽

Vol 10 (5) ◽

Cited By ~ 1

Author(s):

Zahra Farshadzadeh ◽

Mohammad Hossein Modaresi ◽

Behrouz Taheri ◽

Sara Rahimi ◽

Abbas Bahador

Keyword(s):

Antimicrobial Activity ◽

Acinetobacter Baumannii ◽

Drug Resistant ◽

In Vitro Antimicrobial Activity ◽

Extensively Drug Resistant

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The Comparative Efficacy of Colistin Monotherapy and Combination Therapy Based on in vitro Antimicrobial Synergy in Ventilator-associated Pneumonia Caused by Multi-drug Resistant Acinetobacter baumannii

Tuberculosis and Respiratory Diseases ◽

10.4046/trd.2009.67.3.212 ◽

2009 ◽

Vol 67 (3) ◽

pp. 212 ◽

Cited By ~ 11

Author(s):

Hang Jea Jang ◽

Mi-Na Kim ◽

Kwangha Lee ◽

Sang-Bum Hong ◽

Chae-Man Lim ◽

...

Keyword(s):

Combination Therapy ◽

Acinetobacter Baumannii ◽

Ventilator Associated Pneumonia ◽

Drug Resistant ◽

Comparative Efficacy ◽

Antimicrobial Synergy

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Comparison of the treatment efficacy between tigecycline plus high-dose cefoperazone-sulbactam and tigecycline monotherapy against ventilator-associated pneumonia caused by extensively drug-resistant Acinetobacter baumannii

International Journal of Clinical Pharmacology and Therapeutics ◽

10.5414/cp203102 ◽

2018 ◽

Vol 56 (03) ◽

pp. 120-129 ◽

Cited By ~ 3

Author(s):

Youfa Qin ◽

Jie Zhang ◽

Lei Wu ◽

Dailong Zhang ◽

Lunjiao Fu ◽

...

Keyword(s):

Acinetobacter Baumannii ◽

Treatment Efficacy ◽

High Dose ◽

Ventilator Associated Pneumonia ◽

Drug Resistant ◽

Extensively Drug Resistant

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In VitroAntibiotic Synergy in Extensively Drug-ResistantAcinetobacter baumannii: the Effect of Testing by Time-Kill, Checkerboard, and Etest Methods

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.00850-10 ◽

2010 ◽

Vol 55 (1) ◽

pp. 436-438 ◽

Cited By ~ 26

Author(s):

Thean Yen Tan ◽

Tze Peng Lim ◽

Winnie Hui Ling Lee ◽

Suranthran Sasikala ◽

Li Yang Hsu ◽

...

Keyword(s):

Acinetobacter Baumannii ◽

Polymyxin B ◽

Drug Resistant ◽

Extensively Drug Resistant ◽

Resistant Strains ◽

Time Kill

ABSTRACTThis study examined thein vitroeffects of polymyxin B, tigecycline, and rifampin combinations on 16 isolates of extensively drug-resistantAcinetobacter baumannii, including four polymyxin-resistant strains.In vitrosynergy was demonstrated in 19 (40%) of a possible 48 isolate-antibiotic combinations by time-kill methods, 8 (17%) by checkerboard methods, and only 1 (2%) by Etest methods. There was only slight agreement between Etest and checkerboard methods and no agreement between results obtained by other methods.

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