In Vitro Antimicrobial Activity of Dermcidin-1L Against Extensively-Drug-Resistant and Pandrug-Resistant Acinetobacter baumannii

2017 ◽  
Vol 10 (5) ◽  
Author(s):  
Zahra Farshadzadeh ◽  
Mohammad Hossein Modaresi ◽  
Behrouz Taheri ◽  
Sara Rahimi ◽  
Abbas Bahador
Keyword(s):  
Antimicrobial Activity ◽  
Acinetobacter Baumannii ◽  
Drug Resistant ◽  
In Vitro Antimicrobial Activity ◽  
Extensively Drug Resistant

scholarly journals In Vitro Antimicrobial Activity of the Siderophore Cephalosporin Cefiderocol against Acinetobacter baumannii Strains Recovered from Clinical Samples

Antibiotics ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1309
Author(s):  
Davide Carcione ◽  
Claudia Siracusa ◽  
Adela Sulejmani ◽  
Roberta Migliavacca ◽  
Alessandra Mercato ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Acinetobacter Baumannii ◽  
Inhibition Zone ◽  
Broth Microdilution ◽  
Large Variability ◽  
Gold Standard Method ◽  
Disk Diffusion Test ◽  
In Vitro Antimicrobial Activity ◽  
Broth Microdilution Method

Background: Cefiderocol is a siderophore cephalosporin that exhibits antimicrobial activity against most multi-drug resistant Gram-negative bacteria, including Enterobacterales, Pseudomonas aeruginosa, Acinetobacter baumannii, and Stenotrophomonas maltophilia. Methods: A total of 20 multidrug-resistant A. baumannii strains were isolated from 2020 to 2021, molecularly characterized and tested to assess the in vitro antibacterial activity of cefiderocol. Thirteen strains were carbapenem-hydrolysing oxacillinase OXA-23-like producers, while seven were non-OXA-23-like producers. Minimum inhibitory concentrations (MICs) were determined by broth microdilution, considered as the gold standard method. Disk diffusion test was also carried out using iron-depleted CAMHB plates for cefiderocol. Results: Cefiderocol MICs ranged from 0.5 to 1 mg/L for OXA-23-like non-producing A. baumannii strains and from 0.25 to >32 mg/L for OXA-23-like producers, using the broth microdilution method. Cefiderocol MIC90 was 8 mg/L. Diameter of inhibition zone of cefiderocol ranged from 18 to 25 mm for OXA-23-like non-producers and from 15 to 36 mm for OXA-23-like producers, using the diffusion disk method. A large variability and a low reproducibility were observed during the determination of diameter inhibition zone. Molecular characterization showed that all isolates presented the ISAba1 genetic element upstream the blaOXA-51. Among OXA-23-like non-producers, four were blaOXA-58 positive and two were negative for all the resistance determinants analyzed. Conclusions: Cefiderocol showed in vitro antimicrobial activity against both carbapenem-susceptible and non-susceptible A. baumannii strains, although some OXA-23-like producers were resistant. Further clinical studies are needed to consolidate the role of cefiderocol as an antibiotic against MDR A. baumannii.

scholarly journals Correlation of Checkerboard Synergy Testing with Time-Kill Analysis and Clinical Outcomes of Extensively Drug-Resistant Acinetobacter baumannii Respiratory Infections

2016 ◽  
Vol 60 (11) ◽  
pp. 6892-6895 ◽  
Author(s):  
Derek N. Bremmer ◽  
Karri A. Bauer ◽  
Stephanie M. Pouch ◽  
Keelie Thomas ◽  
Debra Smith ◽  
...  
Keyword(s):  
Acinetobacter Baumannii ◽  
Clinical Outcomes ◽  
Clinical Utility ◽  
Respiratory Infections ◽  
Drug Resistant ◽  
Content Type ◽  
Extensively Drug Resistant ◽  
Time Kill ◽  
Synergy Testing

ABSTRACTWe tested 76 extensively drug-resistant (XDR)Acinetobacter baumanniiisolates by the checkerboard method using only wells containing serum-achievable concentrations (SACs) of drugs. Checkerboard results were correlated by time-kill assay and clinical outcomes. Minocycline-colistin was the best combinationin vitro, as it inhibited growth in one or more SAC wells in all isolates. Patients who received a combination that inhibited growth in one or more SAC wells demonstrated better microbiological clearance than those who did not (88% versus 30%;P= 0.025). The checkerboard platform may have clinical utility for XDRA. baumanniiinfections.

In vitro antimicrobial activity of nanoconjugated vancomycin against drug resistant Staphylococcus aureus

2012 ◽  
Vol 436 (1-2) ◽  
pp. 659-676 ◽  
Author(s):  
Subhankari Prasad Chakraborty ◽  
Sumanta Kumar Sahu ◽  
Panchanan Pramanik ◽  
Somenath Roy
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Drug Resistant ◽  
In Vitro Antimicrobial Activity

scholarly journals In vitro antimicrobial activity of five essential oils on multi-drug resistant Gram-negative clinical isolates

2016 ◽  
Vol 5 (3) ◽  
pp. 212 ◽  
Author(s):  
Hercules Sakkas ◽  
Panagiota Gousia ◽  
Vangelis Economou ◽  
Vassilios Sakkas ◽  
Stefanos Petsios ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Essential Oils ◽  
Clinical Isolates ◽  
Drug Resistant ◽  
Gram Negative ◽  
In Vitro Antimicrobial Activity

Antimicrobial activity of novel 4 H -4-oxoquinolizine compounds against extensively drug-resistant Acinetobacter baumannii strains

2017 ◽  
Vol 49 (1) ◽  
pp. 107-111 ◽  
Author(s):  
Seok Hyeon Na ◽  
Hyejin Jeon ◽  
Yoo Jeong Kim ◽  
Hyo Il Kwon ◽  
Gati Noble Selasi ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Acinetobacter Baumannii ◽  
Drug Resistant ◽  
Extensively Drug Resistant

scholarly journals In VitroAntibiotic Synergy in Extensively Drug-ResistantAcinetobacter baumannii: the Effect of Testing by Time-Kill, Checkerboard, and Etest Methods

2010 ◽  
Vol 55 (1) ◽  
pp. 436-438 ◽  
Author(s):  
Thean Yen Tan ◽  
Tze Peng Lim ◽  
Winnie Hui Ling Lee ◽  
Suranthran Sasikala ◽  
Li Yang Hsu ◽  
...  
Keyword(s):  
Acinetobacter Baumannii ◽  
Polymyxin B ◽  
Drug Resistant ◽  
Extensively Drug Resistant ◽  
Resistant Strains ◽  
Time Kill

ABSTRACTThis study examined thein vitroeffects of polymyxin B, tigecycline, and rifampin combinations on 16 isolates of extensively drug-resistantAcinetobacter baumannii, including four polymyxin-resistant strains.In vitrosynergy was demonstrated in 19 (40%) of a possible 48 isolate-antibiotic combinations by time-kill methods, 8 (17%) by checkerboard methods, and only 1 (2%) by Etest methods. There was only slight agreement between Etest and checkerboard methods and no agreement between results obtained by other methods.

scholarly journals Isolation and characterization of Siphoviridae phage infecting extensively drug-resistant Acinetobacter baumannii and evaluation of therapeutic efficacy in vitro and in vivo

2019 ◽  
Vol 68 (7) ◽  
pp. 1096-1108 ◽  
Author(s):  
Phitchayapak Wintachai ◽  
Ampapan Naknaen ◽  
Rattanaruji Pomwised ◽  
Supayang Piyawan Voravuthikunchai ◽  
Duncan R. Smith
Keyword(s):  
Acinetobacter Baumannii ◽  
Therapeutic Efficacy ◽  
Drug Resistant ◽  
Isolation And Characterization ◽  
Extensively Drug Resistant

scholarly journals In vitro activities of rifampin, colistin, sulbactam and tigecycline tested alone and in combination against extensively drug-resistant Acinetobacter baumannii

2014 ◽  
Vol 67 (9) ◽  
pp. 677-680 ◽  
Author(s):  
Xiaomeng Dong ◽  
Fengzhe Chen ◽  
Yajun Zhang ◽  
Haihong Liu ◽  
Yongjuan Liu ◽  
...  
Keyword(s):  
Acinetobacter Baumannii ◽  
Drug Resistant ◽  
Extensively Drug Resistant
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