Tailoring the structure and properties of iron oxide nanoparticles through the oxygen species of borate glass matrix

2020 ◽  
Vol 545 ◽  
pp. 120241
Author(s):  
M. Hamed Misbah ◽  
H. Doweidar ◽  
R. Ramadan ◽  
Maged El-Kemary
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Glass Matrix ◽  
Borate Glass ◽  
Oxide Nanoparticles ◽  
Oxygen Species ◽  
Structure And Properties

Dextran and PEG Coating Reduced Nanoparticle Toxicity to Cells

2012 ◽  
Author(s):  
Miao Yu ◽  
Alisa Morss Clyne
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Cell Mechanics ◽  
Surface Coating ◽  
Biomedical Applications ◽  
Oxide Nanoparticles ◽  
Oxygen Species ◽  
Cell Toxicity ◽  
Peg Coating

Iron oxide nanoparticles are of interest for drug delivery, since they can be targeted using a magnetic field. However, prior to using nanoparticles in vivo, they must be shown as relatively non-toxic to cells. We and others have shown that bare iron oxide nanoparticles are readily taken up by cells, where they catalyze production of highly toxic reactive oxygen species (ROS). This oxidative stress disrupts the cell cytoskeleton and alters cell mechanics. [1] Iron oxide nanoparticles under current development for in vivo biomedical applications are often coated with a polysaccharide (eg. dextran) or a polymer (eg. polyethylene glycol, PEG). Both the size and the surface coating of nanoparticle may play an important role in cell toxicity.

scholarly journals Crystallization and magnetic property of iron oxide nanoparticles precipitated in silica glass matrix

2011 ◽  
Vol 31 (14) ◽  
pp. 2459-2462 ◽  
Author(s):  
Y. Masubuchi ◽  
Y. Sato ◽  
A. Sawada ◽  
T. Motohashi ◽  
H. Kiyono ◽  
...  
Keyword(s):  
Magnetic Property ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Silica Glass ◽  
Glass Matrix ◽  
Oxide Nanoparticles

Structure and Properties of Iron Oxide Nanoparticles Encapsulated by Phospholipids with Poly(ethylene glycol) Tails

2007 ◽  
Vol 111 (49) ◽  
pp. 18078-18086 ◽  
Author(s):  
Eleonora V. Shtykova ◽  
Xinlei Huang ◽  
Nicholas Remmes ◽  
David Baxter ◽  
Barry Stein ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Ethylene Glycol ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Structure And Properties ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

scholarly journals Activatable Superparamagnetic Iron Oxide Nanoparticles Scavenge Reactive Oxygen Species in Macrophages and Endothelial Cells

2020 ◽  
Author(s):  
Chukwuazam Nwasike ◽  
Eunsoo Yoo ◽  
Erin Purr ◽  
Amber L. Doiron
Keyword(s):  
Reactive Oxygen Species ◽  
Endothelial Cells ◽  
Iron Oxide ◽  
Contrast Agent ◽  
Iron Oxide Nanoparticles ◽  
Reactive Oxygen ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Oxygen Species

<p>This study centers around diagnostic medicine, and severity staging of inflammatory diseases. Previously, we showed that complexation of PEG and Poly(gallol) on superparamagnetic iron oxide nanoparticles turn OFF the MRI contrasting ability of the nanoparticle. However, in the presence of reactive oxygen species, the contrast agent will turn ON. In this article, for the first time, we provide evidence that our MRI contrast agent is sensitive to physiologically relevant ROS and induces antioxidant activity on immune and endothelial cells. This study provides initial evidence of IPC-SPIOs cellular ROS sensitivity and potential activatable properties in biological conditions.</p>

scholarly journals Accelerated generation of free radicals by iron oxide nanoparticles in the presence of an alternating magnetic field

RSC Advances ◽  
2015 ◽  
Vol 5 (24) ◽  
pp. 18888-18893 ◽  
Author(s):  
Robert J. Wydra ◽  
Catherine E. Oliver ◽  
Kimberly W. Anderson ◽  
Thomas D. Dziubla ◽  
J. Zach Hilt
Keyword(s):  
Magnetic Field ◽  
Reactive Oxygen Species ◽  
Free Radicals ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Reactive Oxygen ◽  
Alternating Magnetic Field ◽  
Oxide Nanoparticles ◽  
Oxygen Species

The catalytic generation of reactive oxygen species from the surface of iron oxide nanoparticles is enhanced through the activated heating with exposure to an alternating magnetic field.

Iron Oxide Nanoparticles Are Less Toxic to Endothelial Cells When Coated With Dextran and Polyethylene Glycol

2011 ◽  
Author(s):  
Miao Yu ◽  
Vladimir Muzykantov ◽  
Alisa Morss Clyne
Keyword(s):  
Polyethylene Glycol ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Cell Mechanics ◽  
Biomedical Applications ◽  
Oxide Nanoparticles ◽  
Atherosclerotic Plaques ◽  
Oxygen Species ◽  
Cell Functions

Iron oxide nanoparticles are of particular interest for drug delivery applications, since they can be targeted to a specific location using a magnetic field. We are interested in delivering drugs to atherosclerotic plaques via these nanoparticles. However, prior to using nanoparticles in vivo, they must be shown as relatively non-toxic to cells. We and others have shown that bare iron oxide nanoparticles are readily taken up by cells, where they catalyze production of highly toxic reactive oxygen species [1]. This oxidative stress disrupts the cell cytoskeleton, alters cell mechanics, and may change other critical cell functions. Iron oxide nanoparticles for in vivo biomedical applications are often coated with a polysaccharide (eg. dextran) or a polymer (eg. polyethylene glycol, PEG). Both the size and the surface coating of the nanoparticle play an important role in cell toxicity.

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