Gender differences in MRI studies on multiple sclerosis

Background Cognitive function in people with multiple sclerosis (PwMS) is associated with gender differences and the use of smoked/ingested cannabis. Objective The objective of this report is to explore a possible gender-cannabis interaction associated with cognitive dysfunction in PwMS. Methods A retrospective analysis was undertaken of cognitive data collected from 140 PwMS. A general linear model was conducted to determine gender and cannabis effects on processing speed (SDMT), verbal (CVLT-II) and visual (BVMT-R) memory, and executive functions (D-KEFS), while controlling for age and years of education. Results Cannabis was smoked at least once a month by 33 (23.6%) participants. Cannabis users were more impaired on the SDMT ( p = 0.044). Men, who comprised 30.7% of the entire sample and 42.2% of cannabis users, were more impaired on the CVLT-II (total learning, p = 0.001; delayed recall, p = 0.004). A cannabis-gender interaction was found with the CVLT-II delayed recall ( p = 0.049) and BVMT-R total learning ( p = 0.014), where male cannabis users performed more poorly than female. Conclusion Males with MS may be particularly vulnerable to the cognitive side effects of smoked cannabis use.

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Gender differences in circulating levels of neutrophil extracellular traps in serum of multiple sclerosis patients

Journal of Neuroimmunology ◽

10.1016/j.jneuroim.2013.05.004 ◽

2013 ◽

Vol 261 (1-2) ◽

pp. 108-119 ◽

Cited By ~ 25

Author(s):

Kati Tillack ◽

Matthias Naegele ◽

Cathleen Haueis ◽

Sven Schippling ◽

Klaus-Peter Wandinger ◽

...

Keyword(s):

Multiple Sclerosis ◽

Gender Differences ◽

Neutrophil Extracellular Traps ◽

Extracellular Traps ◽

Multiple Sclerosis Patients ◽

Circulating Levels

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Perspectiva de género en el deterioro cognitivo en pacientes con esclerosis múltiple = A gender perspective in the cognitive impairment of multiple sclerosis patients

Cuestiones de género de la igualdad y la diferencia ◽

10.18002/cg.v0i13.5384 ◽

2018 ◽

pp. 389

Author(s):

Mar Estrada ◽

Elena Fernández-Martínez ◽

José Enrique Bayón Darkistade ◽

Cristina Liébana-Presa ◽

Antonio José Molina

Keyword(s):

Multiple Sclerosis ◽

Gender Differences ◽

Cognitive Impairment ◽

General Health ◽

Neurological Dysfunction ◽

Performance Effect ◽

Differential Performance ◽

Physical Deterioration ◽

Esclerosis Múltiple ◽

Multiple Sclerosis Patients

ResumenEl objetivo de la presente investigación es determinar el deterioro cognitivo de pacientes con Esclerosis múltiple (EM) y analizar si existen diferencias de género con EM en las variables: deterioro físico (escala de fatiga EDSS), deterioro cognitivo (STROOP) y salud general (GHQ-28). Participaron 65 personas con EM, con leve disfunción neurológica, de las cuales 17 fueron hombres y 48 mujeres con edades comprendidas entre los 24 y 62 años. Los resultados muestran como la EM afecta a todos los dominios cognitivos y emocionales, probándose un efecto de rendimiento diferencial en relación al género.AbstractThe aim of the present investigation is to determine the cognitive impairment in patients with Multiple Sclerosis (MS) and to analyze whether there are gender differences with MS in the variables: physical deterioration (EDSS fatigue scale), cognitive impairment (STROOP) and general health GHQ-28). A total of 65 MS patients with mild neurological dysfunction were included, of whom 17 were men and 48 were women between the ages of 24 and 62 (mean age = 40 years). The results show how MS disease affects all cognitive and emotional domains, proving a differential performance effect in relation to gender.

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