No evidence of a consistent alteration in the external knee adduction moment during gait in individuals with knee osteoarthritis: a systematic review and meta-analysis

AbstractThe systematic review aimed to analyze the effects of resistance training in knee osteoarthritis (OA) rehabilitation from a biomechanical perspective. A meta-analysis was performed to determine the potential benefits of resistance training on patients with knee OA. Relevant studies based on the inclusion and exclusion criteria were selected from CENTRAL, PubMed, Scopus, and Web of Science databases inception to August 2020. Outcome measures included gait velocity and knee adduction moment (KAM). The mean differences of the data with a 95% confidence interval were analyzed using STATA 15.1 software The search identified eight studies that satisfied all the inclusion criteria, in which 164 patients were involved in gait velocity studies and another 122 patients were part of KAM studies. Analysis of the pooled data showed that resistance training significantly improved the gait velocity in patients with knee OA (p < 0.01, z = 2.73), ES (95% CI) = 0.03 (0.01, 0.06) m/s. However, resistance training had no significant effect on improving KAM in patients with knee OA (p = 0.98, z = 0.03), ES (95% CI) = 0.00 (− 0.16, 0.16) percentage of body weight × height (%BW × Ht). Therefore, resistance training may enhance gait velocity but not KAM in knee OA patients. The protocol was registered at PROSPERO (registration number: CRD42020204897).

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The effects of shoe-worn insoles on gait biomechanics in people with knee osteoarthritis: a systematic review and meta-analysis

British Journal of Sports Medicine ◽

10.1136/bjsports-2016-097108 ◽

2017 ◽

Vol 52 (4) ◽

pp. 238-253 ◽

Cited By ~ 11

Author(s):

Kathryn E Shaw ◽

Jesse M Charlton ◽

Christina K L Perry ◽

Courtney M de Vries ◽

Matthew J Redekopp ◽

...

Keyword(s):

Systematic Review ◽

Knee Osteoarthritis ◽

Methodological Quality ◽

Meta Analysis ◽

Knee Adduction Moment ◽

Future Research ◽

Medial Knee ◽

Gait Biomechanics ◽

Ankle Eversion ◽

Arch Support

ObjectivesThe effect of shoe-worn insoles on biomechanical variables in people with medial knee osteoarthritis has been studied extensively. The majority of research has focused specifically on the effect of lateral wedge insoles at the knee. The aim of this systematic review and meta-analysis was to summarise the known effects of different shoe-worn insoles on all biomechanical variables during level walking in this patient population to date.MethodsFour electronic databases were searched to identify studies containing biomechanical data using shoe-worn insole devices in the knee osteoarthritis population. Methodological quality was assessed and a random effects meta-analysis was performed on biomechanical variables reported in three or more studies for each insole.ResultsTwenty-seven studies of moderate-to-high methodological quality were included in this review. The primary findings were consistent reductions in the knee adduction moment with lateral wedge insoles, although increases in ankle eversion with these insoles were also found.ConclusionLateral wedge insoles produce small reductions in knee adduction angles and external moments, and moderate increases in ankle eversion. The addition of an arch support to a lateral wedge minimises ankle eversion change, and also minimises adduction moment reductions. The paucity of available data on other insole types and other biomechanical outcomes presents an opportunity for future research.

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Association between hip and knee osteoarthritis with falls: a systematic review and meta‐analysis

International Journal of Clinical Practice ◽

10.1111/ijcp.14537 ◽

2021 ◽

Author(s):

Zhen‐han Deng ◽

Jian Xu ◽

Lu‐jue Long ◽

Fei Chen ◽

Kang Chen ◽

...

Keyword(s):

Systematic Review ◽

Knee Osteoarthritis ◽

Meta Analysis

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Does blood flow restriction training enhance clinical outcomes in knee osteoarthritis: A systematic review and meta-analysis

Physical Therapy in Sport ◽

10.1016/j.ptsp.2021.01.014 ◽

2021 ◽

Vol 49 ◽

pp. 37-49

Author(s):

Brayden Grantham ◽

Vasileios Korakakis ◽

Kieran O’Sullivan

Keyword(s):

Systematic Review ◽

Blood Flow ◽

Knee Osteoarthritis ◽

Clinical Outcomes ◽

Meta Analysis ◽

Blood Flow Restriction ◽

Flow Restriction

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Author Reply To “Regarding ‘Intra-articular Mesenchymal Stromal Cell Injections Are No Different From Placebo in the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-analysis of Randomized Controlled Trials’”

Arthroscopy The Journal of Arthroscopic and Related Surgery ◽

10.1016/j.arthro.2021.02.025 ◽

2021 ◽

Vol 37 (5) ◽

pp. 1362-1364

Author(s):

Wenli Dai ◽

Xi Leng ◽

Jian Wang ◽

Zhanjun Shi ◽

Jin Cheng ◽

...

Keyword(s):

Systematic Review ◽

Knee Osteoarthritis ◽

Randomized Controlled Trials ◽

Mesenchymal Stromal Cell ◽

Stromal Cell ◽

Meta Analysis ◽

Controlled Trials ◽

Author Reply ◽

Randomized Controlled

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Effects of mechanical interventions in the management of knee osteoarthritis: protocol for an OA Trial Bank systematic review and individual participant data meta-analysis

BMJ Open ◽

10.1136/bmjopen-2020-043026 ◽

2021 ◽

Vol 11 (2) ◽

pp. e043026

Author(s):

Erin M Macri ◽

Michael Callaghan ◽

Marienke van Middelkoop ◽

Miriam Hattle ◽

Sita M A Bierma-Zeinstra

Keyword(s):

Systematic Review ◽

Knee Osteoarthritis ◽

Broad Class ◽

Meta Analysis ◽

Individual Participant Data ◽

Knee Oa ◽

International Regulations ◽

Individual Participant ◽

Registration Number ◽

Mechanical Intervention

IntroductionKnee osteoarthritis (OA) is a prevalent and disabling musculoskeletal condition. Biomechanical factors may play a key role in the aetiology of knee OA, therefore, a broad class of interventions involves the application or wear of devices designed to mechanically support knees with OA. These include gait aids, bracing, taping, orthotics and footwear. The literature regarding efficacy of mechanical interventions has been conflicting or inconclusive, and this may be because certain subgroups with knee OA respond better to mechanical interventions. Our primary aim is to identify subgroups with knee OA who respond favourably to mechanical interventions.Methods and analysisWe will conduct a systematic review to identify randomised clinical trials of any mechanical intervention for the treatment of knee OA. We will invite lead authors of eligible studies to share individual participant data (IPD). We will perform an IPD meta-analysis for each type of mechanical intervention to evaluate efficacy, with our main outcome being pain. Where IPD are not available, this will be achieved using aggregate data. We will then evaluate five potential treatment effect modifiers using a two-stage approach. If data permit, we will also evaluate whether biomechanics mediate the effects of mechanical interventions on pain in knee OA.Ethics and disseminationNo new data will be collected in this study. We will adhere to institutional, national and international regulations regarding the secure and confidential sharing of IPD, addressing ethics as indicated. We will disseminate findings via international conferences, open-source publication in peer-reviewed journals and summaries posted on websites serving the public and clinicians.PROSPERO registration numberCRD42020155466.

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