Directional fractal signature analysis of trabecular bone and its relation to incident radiographic knee osteoarthritis: 30, 60 and 84-month follow-up data from the most cohort

ObjectiveTo evaluate whether T2 relaxation time measurements obtained at 3 T MRI predict the onset of radiographic knee osteoarthritis (OA).Materials and methodsWe performed a nested case–control study of incident radiographic knee OA in the Osteoarthritis Initiative cohort. Cases were 50 knees with baseline Kellgren–Lawrence (KL) grade of 0 that developed KL grade of 2 or more over a 4-year period. Controls were 80 knees with KL grade of 0 after 4 years of follow-up. Baseline T2 relaxation time measurements and laminar analysis of T2 in deep and superficial layers were performed in all knee compartments. The association of T2 values with incident OA was assessed with logistic regression and differences in T2 values by case–control status with linear regression, adjusting for age, sex, body mass index (BMI) and other covariates.ResultsBaseline T2 values in all compartments except the medial tibia were significantly higher in knees that developed OA compared with controls and were particularly elevated in the superficial cartilage layers in all compartments. There was an increased likelihood of incident knee OA associated with higher baseline T2 values, particularly in the patella, adjusted OR per 1 SD increase in T2 (3.37 (95% CI 1.72 to 6.62)), but also in the medial femur (1.90 (1.07 to 3.39)), lateral femur (2.17 (1.11 to 4.25)) and lateral tibia (2.23 (1.16 to 4.31)).ConclusionsThese findings suggest that T2 values assessed when radiographic changes are not yet apparent may be useful in predicting the development of radiological tibiofemoral OA.

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018 RELATIONSHIP OF WEIGHT CHANGE WITH CHANGE IN KNEE PAIN AND FUNCTION IN PERSONS WITH SYMPTOMATIC RADIOGRAPHIC KNEE OSTEOARTHRITIS: ONE-YEAR FOLLOW-UP DATA FROM THE OSTEOARTHRITIS INITIATIVE

Osteoarthritis and Cartilage ◽

10.1016/s1063-4584(09)60041-8 ◽

2009 ◽

Vol 17 ◽

pp. S18

Author(s):

M.C. Hochberg ◽

K. Favors ◽

D. Bujak ◽

T. Niculescu ◽

S. Bartlett ◽

...

Keyword(s):

Knee Osteoarthritis ◽

Knee Pain ◽

Weight Change ◽

Osteoarthritis Initiative ◽

One Year ◽

And Function ◽

Relationship Of ◽

Radiographic Knee Osteoarthritis

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Chondroitin sulfate and glucosamine supplementation is associated with higher incidence of radiographic knee osteoarthritis and subsequent knee replacement: nine years of follow-up data from the osteoarthritis initiative

Osteoarthritis and Cartilage ◽

10.1016/j.joca.2016.01.554 ◽

2016 ◽

Vol 24 ◽

pp. S307

Author(s):

S. Demehri ◽

N. Hafezi Nejad ◽

F. Roemer ◽

A. Guermazi

Keyword(s):

Knee Osteoarthritis ◽

Chondroitin Sulfate ◽

Knee Replacement ◽

Osteoarthritis Initiative ◽

Radiographic Knee Osteoarthritis

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Knee extensor muscle weakness is a risk factor for the development of knee osteoarthritis: an updated systematic review and meta-analysis including 46 819 men and women

British Journal of Sports Medicine ◽

10.1136/bjsports-2021-104861 ◽

2021 ◽

pp. bjsports-2021-104861

Author(s):

Britt Elin Øiestad ◽

Carsten B Juhl ◽

Adam G Culvenor ◽

Bjørnar Berg ◽

Jonas Bloch Thorlund

Keyword(s):

Systematic Review ◽

Knee Osteoarthritis ◽

Muscle Weakness ◽

Meta Analysis ◽

Knee Extensor ◽

Extensor Muscle ◽

Knee Extensor Muscle Strength ◽

Quality Evidence ◽

Radiographic Knee Osteoarthritis

ObjectiveTo update a systematic review on the association between knee extensor muscle weakness and the risk of incident knee osteoarthritis in women and men.DesignSystematic review and meta-analysis.Data sourcesSystematic searches in PubMed, EMBASE, SPORTDiscus, CINAHL, AMED and CENTRAL in May 2021.Eligible criteria for selecting studiesLongitudinal studies with at least 2 years follow-up including baseline measure of knee extensor muscle strength, and follow-up measure of symptomatic or radiographic knee osteoarthritis. Studies including participants with known knee osteoarthritis at baseline were excluded. Risk of bias assessment was conducted using six criteria for study validity and bias. Grading of Recommendations Assessments, Development and Evaluation assessed overall quality of evidence. Meta-analysis estimated the OR for the association between knee extensor muscle weakness and incident knee osteoarthritis.ResultsWe included 11 studies with 46 819 participants. Low quality evidence indicated that knee extensor muscle weakness increased the odds of symptomatic knee osteoarthritis in women (OR 1.85, 95% CI 1.29 to 2.64) and in adult men (OR 1.43, 95% CI 1.14 to 1.78), and for radiographic knee osteoarthritis in women: OR 1.43 (95% CI 1.19 to 1.71) and in men: OR 1.39 (95% CI 1.07 to 1.82). No associations were identified for knee injured populations except for radiographic osteoarthritis in men.DiscussionThere is low quality evidence that knee extensor muscle weakness is associated with incident symptomatic and radiographic knee osteoarthritis in women and men. Optimising knee extensor muscle strength may help to prevent knee osteoarthritis.PROSPERO registration numberCRD42020214976.

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