scholarly journals Association of mucoid degeneration of anterior cruciate ligament with knee meniscal and cartilage damage

2015 ◽  
Vol 23 (9) ◽  
pp. 1543-1550 ◽  
Author(s):  
R.M. Kwee ◽  
S. Ahlawat ◽  
A.J. Kompel ◽  
J.N. Morelli ◽  
L.M. Fayad ◽  
...  
Keyword(s):  
Anterior Cruciate Ligament ◽  
Cruciate Ligament ◽  
Cartilage Damage ◽  
Mucoid Degeneration ◽  
Anterior Cruciate ◽  
And Cartilage

Anterior Cruciate Ligament Failure and Cartilage Damage during Knee Joint Compression

2008 ◽  
Vol 36 (5) ◽  
pp. 934-942 ◽  
Author(s):  
Chen Hua Yeow ◽  
Chee Hoong Cheong ◽  
Kian Siang Ng ◽  
Peter Vee Sin Lee ◽  
James Cho Hong Goh
Keyword(s):  
Anterior Cruciate Ligament ◽  
Knee Joint ◽  
Cruciate Ligament ◽  
Cartilage Damage ◽  
Ligament Failure ◽  
Anterior Cruciate ◽  
And Cartilage

scholarly journals Association Between MRI-Based Tibial Slope Measurements and Mucoid Degeneration of the Anterior Cruciate Ligament: A Propensity Score–Matched Case-Control Study

2020 ◽  
Vol 8 (11) ◽  
pp. 232596712096280
Author(s):  
Bashir Zikria ◽  
Alex Johnson ◽  
Nima Hafezi-Nejad ◽  
Yalda Siddiqui ◽  
Robert M. Kwee ◽  
...  
Keyword(s):  
Anterior Cruciate Ligament ◽  
Propensity Score ◽  
Cruciate Ligament ◽  
Cartilage Damage ◽  
Tibial Slope ◽  
Mucoid Degeneration ◽  
Knee Mri ◽  
Independent Expert ◽  
Internal Joint ◽  
Anterior Cruciate

Background: The cause of mucoid degeneration (MD) of the anterior cruciate ligament (ACL), which is commonly observed on magnetic resonance imaging (MRI) of patients with knee pain, has yet to be elucidated. Despite the limited evidence on the relationship between ACL lesions (injury and MD) and tibial morphologic features (ie, posterior tibial slope), the potential association between the presence of ACL MD and medial and lateral tibial slope (MTS and LTS) has not been well-established. Purpose: To investigate whether MTS and LTS measurements are associated with the presence of ACL MD. Study Design: Cross-sectional study; Level of evidence, 3. Methods: Consecutive knee MRI examinations of patients referred by an orthopaedic surgeon for potential internal joint derangements were identified within a 4-year period. The presence of ACL MD and the MTS/LTS values were assessed by independent expert observers in consensus in a blinded fashion. From 413 consecutive knee MRI scans, a sample of 80 knees, including 32 knees with ACL MD (cases) and 48 knees with normal ACL (controls), were selected using propensity score matching method for age, sex, body mass index, and presence of severe medial tibiofemoral compartment cartilage damage. The association between ACL MD and MTS/LTS was evaluated using conditional regression models. Results: Knees with ACL MD had higher values of LTS (mean ± SD, 7.18° ± 3.58°) in comparison with control knees (5.32° ± 3.35°). Conditional regression analysis revealed a significant association between LTS measurements (not MTS) and ACL MD; every 1° increase in LTS was associated with a 17% (95% CI, 1%-35%) higher probability of having ACL MD. Conclusion: Excessive LTS was associated with the presence of ACL MD, independent of participants’ age, sex, BMI, and cartilage damage severity.

scholarly journals Coefficients of friction, lubricin, and cartilage damage in the anterior cruciate ligament-deficient guinea pig knee

2008 ◽  
Vol 26 (2) ◽  
pp. 231-237 ◽  
Author(s):  
Erin Teeple ◽  
Khaled A. Elsaid ◽  
Braden C. Fleming ◽  
Gregory D. Jay ◽  
Koosha Aslani ◽  
...  
Keyword(s):  
Anterior Cruciate Ligament ◽  
Guinea Pig ◽  
Cruciate Ligament ◽  
Cartilage Damage ◽  
Anterior Cruciate ◽  
Anterior Cruciate Ligament Deficient ◽  
And Cartilage

scholarly journals Clinical Outcomes of Arthroscopic Notchplasty and Partial Resection for Mucoid Degeneration of the Anterior Cruciate Ligament

2021 ◽  
Vol 10 (2) ◽  
pp. 315
Author(s):  
Joong Won Lee ◽  
Jung Tae Ahn ◽  
Hyun Gon Gwak ◽  
Sang Hak Lee
Keyword(s):  
Anterior Cruciate Ligament ◽  
Clinical Outcomes ◽  
Cruciate Ligament ◽  
Arthroscopic Surgery ◽  
Partial Resection ◽  
Knee Score ◽  
Mucoid Degeneration ◽  
Duration Of Symptoms ◽  
Significant Difference ◽  
Anterior Cruciate

Background: Mucoid degeneration of the anterior cruciate ligament (MD-ACL) is a chronic degenerative process involving a hypertrophied ACL, which may lead to notch impingement syndrome. As a treatment method, there is consensus regarding arthroscopic resection for MD-ACL resulting in good clinical outcomes; however, additional notchplasty remains controversial. The purpose of this study was to investigate clinical outcomes after arthroscopic partial resection of the ACL and additional notchplasty performed to minimize volume reduction of the ACL. Study Design: Level IIIb retrospective cohort study. Methods: Of 1810 individuals who underwent knee arthroscopic surgery performed by the same surgeon between July 2011 and October 2020, 52 were included, while 10 were excluded due to a follow-up period of <1 year. Clinical data including pain location, terminal flexion or extension pain, range of motion (ROM), Lysholm knee score, and Hospital for Special Surgery (HSS) knee score were assessed pre- and postoperatively. Additionally, according to the resected volume of the ACL, patients were classified into two groups: <25% (Group 1), and 25–50% (Group 2). Clinical outcomes were compared between the two groups. Results: There were 17 (40.5%) men and 25 (59.5%) women with a mean age of 53.9 years (range, 16–81 years) at the time of surgery. The mean duration of symptoms before surgery was 14.4 months (range, 3–66 months). Arthroscopic partial resection of the MD-ACL was performed in all patients, and concomitant notchplasty was performed in 36 (81.8%). All clinical scores improved postoperatively, and were statistically significant (p < 0.01). However, there was no significant difference in clinical outcomes between groups 1 and 2 classified according to the resected ACL volume. Recurrence of MD-ACL was recorded in only one patient, 11 months after arthroscopic treatment. No patients underwent ACL reconstruction because of symptoms of anterior instability. Conclusion: Arthroscopic partial resection of the ACL and concomitant notchplasty yielded satisfactory outcomes for the treatment of MD-ACL. Notchplasty may be an alternative procedure to avoid total ACL resection and postoperative instability.

Risk factors for progression of articular cartilage damage after anatomical anterior cruciate ligament reconstruction

2018 ◽  
Vol 100-B (3) ◽  
pp. 285-293 ◽  
Author(s):  
A. Nakamae ◽  
N. Adachi ◽  
M. Deie ◽  
M. Ishikawa ◽  
T. Nakasa ◽  
...  
Keyword(s):  
Risk Factors ◽  
Anterior Cruciate Ligament ◽  
Articular Cartilage ◽  
Acl Reconstruction ◽  
Cruciate Ligament ◽  
Cartilage Damage ◽  
Significant Risk ◽  
Articular Cartilage Damage ◽  
Anterior Cruciate

Aims To investigate the risk factors for progression of articular cartilage damage after anatomical anterior cruciate ligament (ACL) reconstruction. Patients and Methods A total of 174 patients who underwent second-look arthroscopic evaluation after anatomical ACL reconstruction were enrolled in this study. The graded condition of the articular cartilage at the time of ACL reconstruction was compared with that at second-look arthroscopy. Age, gender, body mass index (BMI), ACL reconstruction technique, meniscal conditions, and other variables were assessed by regression analysis as risk factors for progression of damage to the articular cartilage. Results In the medial compartment, multivariable logistic regression analysis indicated that partial medial meniscectomy (odds ratio (OR) 6.82, 95% confidence interval (CI) 2.11 to 22.04, p = 0.001), pivot-shift test grade at the final follow-up (OR 3.53, CI 1.39 to 8.96, p = 0.008), BMI (OR 1.15, CI 1.03 to 1.28, p = 0.015) and medial meniscal repair (OR 3.19, CI 1.24 to 8.21, p = 0.016) were significant risk factors for progression of cartilage damage. In the lateral compartment, partial lateral meniscectomy (OR 10.94, CI 4.14 to 28.92, p < 0.001) and side-to-side differences in anterior knee laxity at follow-up (OR 0.63, p = 0.001) were significant risk factors. Conclusion Partial meniscectomy was found to be strongly associated with the progression of articular cartilage damage despite r anatomical ACL reconstruction. Cite this article: Bone Joint J 2018;100-B:285–93.

scholarly journals Anterior Cruciate Ligament Ganglion Cyst and Mucoid Degeneration: A Review

Cureus ◽  
2017 ◽  
Author(s):  
Raju Vaishya ◽  
Abdulrazaq Esin Issa ◽  
Amit Kumar Agarwal ◽  
Vipul Vijay
Keyword(s):  
Anterior Cruciate Ligament ◽  
Ganglion Cyst ◽  
Cruciate Ligament ◽  
Mucoid Degeneration ◽  
Anterior Cruciate

Matrix Metalloproteinase Inhibition With Doxycycline Affects the Progression of Posttraumatic Osteoarthritis After Anterior Cruciate Ligament Rupture: Evaluation in a New Nonsurgical Murine ACL Rupture Model

2019 ◽  
Vol 48 (1) ◽  
pp. 143-152 ◽  
Author(s):  
Xueying Zhang ◽  
Xiang-Hua Deng ◽  
Zhe Song ◽  
Brett Croen ◽  
Camila B. Carballo ◽  
...  
Keyword(s):  
Anterior Cruciate Ligament ◽  
Matrix Metalloproteinase ◽  
Untreated Control ◽  
Cruciate Ligament ◽  
Cartilage Damage ◽  
Acl Rupture ◽  
Male Mice ◽  
Posttraumatic Osteoarthritis ◽  
Rupture Model ◽  
Anterior Cruciate

Background: Doxycycline has broad-spectrum activity as a matrix metalloproteinase (MMP) inhibitor and thus could reduce the progression of posttraumatic osteoarthritis (PTOA) after anterior cruciate ligament (ACL) rupture. Hypothesis: Doxycycline would inhibit progression of PTOA in a murine ACL rupture model. Study Design: Controlled laboratory study. Methods: For the in vitro study, cadaveric C57BL/6 male mice knees (N = 108) were used for the development of a nonsurgical ACL rupture model. For the in vivo study, 24 C57BL/6 male mice then underwent ACL rupture with our manual procedure and were divided into 4 groups: untreated control; doxycycline, 10 mg/kg/d; doxycycline, 50 mg/kg/d; and doxycycline, 100 mg/kg/d. Doxycycline was administered in drinking water beginning immediately after ACL rupture. Radiographic imaging and paw prints were evaluated at 3, 7, 14, and 28 days. The foot length and toe spread were analyzed as measures of function. Histology and MMP-13 immunohistochemistry were done at 4 weeks. Results: Radiographs demonstrated anterior tibial subluxation and meniscal extrusion after ACL rupture, confirming knee joint instability without fractures. Statistically significant differences in gait were found between the intact and experimental groups. Histologic examination demonstrated cartilage damage, meniscal tears, and mild osteoarthritis after ACL rupture, similar to what occurs in human patients. Hypertrophy of the posterior horn of the medial and lateral meniscus was found, and tears of the posterior horn of the menisci were common. All doxycycline groups had a lower score than the untreated control group, indicating less cartilage damage. The posterior tibia of the untreated group had the most cartilage damage as compared with the 3 doxycycline groups, with a significant difference between the untreated and 50-mg/kg/d doxycycline groups, suggesting that the latter dose may protect against proteoglycan loss and decrease the progression of osteoarthritis. The nondoxycycline group had the highest synovial inflammation score among all groups, indicating that doxycycline has an inhibitory effect on synovitis. There was significantly lower MMP-13 expression on the tibia in the doxycycline-treated groups, with a positive correlation between doxycycline concentration and MMP-13 inhibition. Conclusion: Modulation of MMP-13 activity by doxycycline treatment may offer a novel biological pathway to decrease the progression of PTOA after ACL rupture. Clinical Relevance: Doxycycline is an approved, readily available drug with infrequent side effects of photosensitivity and gastrointestinal symptoms. Future clinical trials could evaluate doxycycline to reduce or prevent progressive cartilage damage after ACL rupture.

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