scholarly journals Synovitis does not mediate the relationship between body mass index and progression of radiographic knee osteoarthritis: data from the osteoarthritis initiative

2021 ◽  
Vol 29 ◽  
pp. S275-S276
Author(s):  
M. Banuls-Mirete ◽  
A. Lombardi ◽  
A.H. Shadyab ◽  
E. Chang ◽  
N.E. Lane ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Knee Osteoarthritis ◽  
Body Mass ◽  
Osteoarthritis Initiative ◽  
The Relationship ◽  
Radiographic Knee Osteoarthritis

scholarly journals Static Knee Alignment Measurements among Caucasians and African Americans: The Johnston County Osteoarthritis Project

2009 ◽  
Vol 36 (9) ◽  
pp. 1987-1990 ◽  
Author(s):  
AMANDA E. NELSON ◽  
LARISSA BRAGA ◽  
ANDRESA BRAGA-BAIAK ◽  
JULIUS ATASHILI ◽  
TODD A. SCHWARTZ ◽  
...  
Keyword(s):  
Body Mass Index ◽  
African Americans ◽  
Knee Osteoarthritis ◽  
Body Mass ◽  
Tibial Plateau ◽  
Knee Alignment ◽  
Anatomic Axis ◽  
Radiographic Knee Osteoarthritis

Objective.To determine if knee alignment measures differ between African Americans and Caucasians without radiographic knee osteoarthritis (rOA).Methods.A single knee was randomly selected from 175 participants in the Johnston County Osteoarthritis Project without rOA in either knee. Anatomic axis, condylar, tibial plateau, and condylar plateau angles were measured by 1 radiologist; means were compared and adjusted for age and body mass index (BMI).Results.There were no significant differences in knee alignment measurements between Caucasians and African Americans among men or women.Conclusion.Observed differences in knee rOA occurrence between African Americans and Caucasians are not explained by differences in static knee alignment.

scholarly journals Older Adults without Radiographic Knee Osteoarthritis: Knee Alignment and Knee Range of Motion

2014 ◽  
Vol 7 ◽  
pp. CMAMD.S13009 ◽  
Author(s):  
Lissa Fahlman ◽  
Emmeline Sangeorzan ◽  
Nimisha Chheda ◽  
Daphne Lambright
Keyword(s):  
Body Mass Index ◽  
Knee Osteoarthritis ◽  
Range Of Motion ◽  
Body Mass ◽  
Knee Alignment ◽  
Community Based ◽  
Osteoarthritis Knee ◽  
And Gender ◽  
Complex Relationships ◽  
Radiographic Knee Osteoarthritis

This study describes knee alignment and active knee range of motion (ROM) in a community-based group of 78-year old adults (n = 143) who did not have radiographic evidence of knee osteoarthritis in either knee (KL < 2). Although knee malalignment is a risk factor for knee osteoarthritis, most women and men had either valgus or varus alignments. Notably, no men were valgus in both knees. Women with both knees valgus had significantly greater body mass index ( P > 0.001) than women with varus or straight knees. Men and women with valgus or varus knee alignments had generally lower ROM than individuals with both knees straight. In summary, this study highlights the complex relationships among knee alignment, ROM, body mass index, and gender in elderly adults without radiographic knee osteoarthritis.

scholarly journals Body Mass Index Mediates the Association between Dietary Fiber and Symptomatic Knee Osteoarthritis in the Osteoarthritis Initiative and the Framingham Osteoarthritis Study

2018 ◽  
Vol 148 (12) ◽  
pp. 1961-1967 ◽  
Author(s):  
Zhaoli Dai ◽  
S Reza Jafarzadeh ◽  
Jingbo Niu ◽  
David T Felson ◽  
Paul F Jacques ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Knee Osteoarthritis ◽  
Dietary Fiber ◽  
Body Mass ◽  
Framingham Study ◽  
Inverse Association ◽  
Fiber Intake ◽  
Symptomatic Knee Osteoarthritis ◽  
Symptomatic Knee ◽  
Osteoarthritis Initiative

ABSTRACT Background Dietary fiber reduces body weight and inflammation in clinical trials. It is unclear whether body mass index (BMI) and inflammation might explain the observed association between higher fiber intake and the lower risk of symptomatic knee osteoarthritis (SXKOA). Objectives We quantified the extent to which BMI and inflammation influenced the relation between dietary fiber and SXKOA. Methods We used longitudinal data from the Osteoarthritis Initiative (OAI) and the Framingham Offspring Osteoarthritis Study. At baseline of each study, men and women (mean age: 61 y) with or at risk of knee osteoarthritis were followed for 48 mo in the OAI. Adults (mean age: 53 y) were followed for 9.5 y in the Framingham study. Dietary fiber intake was estimated using a validated food-frequency questionnaire. Measured weight and height were used to calculate BMI. Serum high-sensitivity C-reactive protein (CRP) was measured in the Framingham study only. Incident SXKOA was defined as new onset of a combination of knee pain and radiographic osteoarthritis. We applied marginal structural models to quantify the mediation through BMI in the OAI and the sequential mediation through BMI and CRP in the Framingham study. Results Incident SXKOA occurred in 861 knees among 2876 persons in the OAI and in 143 knees among 971 persons in the Framingham study. In persons whose fiber intake was ≥21 g/d compared with those with intakes <21 g/d, the OR (95% CI) was 0.70 (0.53, 0.91) for the overall association with SXKOA and was 0.93 (0.92, 0.95) for the mediation via BMI (per kg/m2) in the OAI. In the Framingham study, the overall association was 0.57 (0.30, 1.09), the mediation through BMI (via BMI and the influence of BMI on CRP) was 0.94 (0.85, 1.02), and the mediation through CRP (per milligram per liter) was 0.99 (0.84, 1.19). Conclusion Our findings suggest that the inverse association of fiber intake and the risk of incident symptomatic knee osteoarthritis is partially mediated by BMI.

Relationship between Leptin Concentration in Cord Blood and Foetal Growth and Maternal Anthropometry of GDM Mothers at Delivery

1970 ◽  
Vol 25 (1) ◽  
pp. 9-13
Author(s):  
S Jahan ◽  
TR Das ◽  
KB Biswas
Keyword(s):  
Body Mass Index ◽  
Birth Weight ◽  
Cord Blood ◽  
Body Mass ◽  
Anthropometric Measurements ◽  
Anthropometric Parameters ◽  
Serum Leptin ◽  
C Peptide ◽  
Cord Serum ◽  
The Relationship

Background and Aims: Cord blood leptin may reflect the leptinemic status of a newborn at birth more accurately than the leptin values of blood collected from other sites. The present study was undertaken to determine the relationship of cord serum leptin concentration at birth with neonatal and maternal anthropometric parameters. Materials and Methods: Blood was taken from the umbilical cord of the babies at delivery. Maternal anthropometric measurements were recorded at admission for delivery. Neonatal anthropometric measurements were recorded within 48 hours after delivery. Linear regression analysis was used to explore the relationship between cord serum leptin concentration and anthropometric parameters of the baby and the mother. Both Serum leptin and serum C-peptide levels were measured by chemiluminescence-based ELISA method. Results: The leptin concentration (ng/ml, mean±SD) in cord blood was 39.13±14.44. Cord leptin levels correlated with birth weight (r=0.673, p<0.0001), ponderal index (r=0.732, p<0.0001) but it did not correlate with maternal body mass index, gestational age (r=0.135, p=0.349) at delivery or cord serum C-peptide concentration (r=-0.049, p=0.735) or placental weight (r=0.203, p=0.157). Conclusion: There are associations between cord leptin concentration at delivery and birth weight, ponderal index (PI) of the babies but not body mass index (BMI) of the mothers. High leptin levels of the baby could represent an important feedback modulator of substrate supply and subsequently for adipose tissue status during late gestation. (J Bangladesh Coll Phys Surg 2007; 25 : 9-13)

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