Effect of different types of electrical stimulation on intracellular calcium levels in human mesenchymal stem cells and chondrocytes

2021 ◽  
Vol 29 ◽  
pp. S408-S409
Author(s):  
R. Vaiciuleviciute ◽  
I. Uzieliene ◽  
A. Alaburda ◽  
V. Novickij ◽  
A. Mobasheri ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Electrical Stimulation ◽  
Intracellular Calcium ◽  
Human Mesenchymal Stem Cells ◽  
Different Types

Electrical Stimulation of Human Mesenchymal Stem Cells on Conductive Nanofibers Enhances their Differentiation toward Osteogenic Outcomes

2015 ◽  
Vol 36 (21) ◽  
pp. 1884-1890 ◽  
Author(s):  
John G. Hardy ◽  
Maria K. Villancio-Wolter ◽  
Rushi C. Sukhavasi ◽  
David J. Mouser ◽  
David Aguilar ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Electrical Stimulation ◽  
Human Mesenchymal Stem Cells ◽  
Stimulation Of

scholarly journals Control of Differentiation of Human Mesenchymal Stem Cells by Altering the Geometry of Nanofibers

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Satoshi Fujita ◽  
Harue Shimizu ◽  
Shin-ichiro Suye
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells ◽  
Clinical Applications ◽  
Soluble Factors ◽  
Precise Control ◽  
Mixed Medium ◽  
Aligned Nanofibers ◽  
Different Types ◽  
Msc Differentiation

Effective differentiation of mesenchymal stem cells (MSCs) is required for clinical applications. To control MSC differentiation, induction media containing different types of soluble factors have been used to date; however, it remains challenging to obtain a uniformly differentiated population of an appropriate quality for clinical application by this approach. We attempted to develop nanofiber scaffolds for effective MSC differentiation by mimicking anisotropy of the extracellular matrix structure, to assess whether differentiation of these cells can be controlled by using geometrically different scaffolds. We evaluated MSC differentiation on aligned and random nanofibers, fabricated by electrospinning. We found that induction of MSCs into adipocytes was markedly more inhibited on random nanofibers than on aligned nanofibers. In addition, adipoinduction on aligned nanofibers was also inhibited in the presence of mixed adipoinduction and osteoinduction medium, although osteoinduction was not affected by a change in scaffold geometry. Thus, we have achieved localized control over the direction of differentiation through changes in the alignment of the scaffold even in the presence of a mixed medium. These findings indicate that precise control of MSC differentiation can be attained by using scaffolds with different geometry, rather than by the conventional use of soluble factors in the medium.

Neurogenesis Is Induced by Electrical Stimulation of Human Mesenchymal Stem Cells Co-Cultured With Mature Neuronal Cells

2015 ◽  
Vol 15 (11) ◽  
pp. 1586-1594 ◽  
Author(s):  
Sang Jun Park ◽  
Ji Sun Park ◽  
Han Na Yang ◽  
Se Won Yi ◽  
Chun-Ho Kim ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Electrical Stimulation ◽  
Neuronal Cells ◽  
Human Mesenchymal Stem Cells ◽  
Stimulation Of

scholarly journals Electrical Stimulation Changes Human Mesenchymal Stem Cells Orientation and Cytoskeleton Organization

2017 ◽  
Vol 7 (9) ◽  
pp. 829-833 ◽  
Author(s):  
Sahba Mobini ◽  
Ülle-Linda Talts ◽  
Ruikang Xue ◽  
Nigel J. Cassidy ◽  
Sarah H. Cartmell
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Electrical Stimulation ◽  
Human Mesenchymal Stem Cells ◽  
Cytoskeleton Organization

scholarly journals Directing lineage specification of human mesenchymal stem cells by decoupling electrical stimulation and physical patterning on unmodified graphene

Nanoscale ◽  
2016 ◽  
Vol 8 (28) ◽  
pp. 13730-13739 ◽  
Author(s):  
Daniel A. Balikov ◽  
Brian Fang ◽  
Young Wook Chun ◽  
Spencer W. Crowder ◽  
Dhiraj Prasai ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Electrical Stimulation ◽  
Human Mesenchymal Stem Cells ◽  
Lineage Specification

scholarly journals Electrical stimulation of human mesenchymal stem cells on biomineralized conducting polymers enhances their differentiation towards osteogenic outcomes

2015 ◽  
Vol 3 (41) ◽  
pp. 8059-8064 ◽  
Author(s):  
John G. Hardy ◽  
Rushi C. Sukhavasi ◽  
David Aguilar ◽  
Maria K. Villancio-Wolter ◽  
David J. Mouser ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Electrical Stimulation ◽  
Conducting Polymers ◽  
Human Mesenchymal Stem Cells ◽  
Tissue Scaffolds ◽  
Stimulation Of

Tissue scaffolds allowing the behaviour of the cells that reside on them to be controlled are of particular interest for tissue engineering.

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