Evaluation of Blood Clot, Platelet-rich Plasma, Platelet-rich Fibrin, and Platelet Pellet as Scaffolds in Regenerative Endodontic Treatment: A Prospective Randomized Trial

The management of necrotic immature permanent teeth has always been a challenge to endodontists. Various treatment modalities have been tried and tested for achieving a successful outcome. Revascularisation is one among these treatment options, which is gaining widespread attention among endodontists. The growing body of evidence demonstrating the success of revascularisation has led to different variations of this treatment option. Clinicians have over time used different scaffolds such as blood clot, collagen, platelet-rich fibrin (PRF) and platelet-rich plasma for revascularisation. This case report outlines the management of immature maxillary central incisors with pulp necrosis and large periapical lesions in a 19-year-old female patient with a modified technique of revascularisation by combining PRF and blood clot. At the end of 12 months, the patient was completely asymptomatic along with regression of the periapical lesions.

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The efficacy of platelet-rich fibrin as a scaffold in regenerative endodontic treatment: a retrospective controlled cohort study

BMC Oral Health ◽

10.1186/s12903-018-0598-z ◽

2018 ◽

Vol 18 (1) ◽

Cited By ~ 5

Author(s):

Hongbing Lv ◽

Yuemin Chen ◽

Zhiyu Cai ◽

Lishan Lei ◽

Ming Zhang ◽

...

Keyword(s):

Cohort Study ◽

Endodontic Treatment ◽

Platelet Rich Fibrin ◽

Regenerative Endodontic Treatment

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A comparative evaluation of Advanced Platelet-Rich Fibrin (A-PRF) and Platelet-Rich Fibrin (PRF) as a Scaffold in Regenerative Endodontic Treatment of Traumatized Immature Non-vital permanent anterior teeth: A Prospective clinical study

Journal of Clinical and Experimental Dentistry ◽

10.4317/jced.57902 ◽

2021 ◽

pp. e463-e472

Author(s):

V. Jayadevan ◽

P. Gehlot ◽

V. Manjunath ◽

SV. Madhunapantula ◽

J. Lakshmikanth

Keyword(s):

Clinical Study ◽

Comparative Evaluation ◽

Endodontic Treatment ◽

Prospective Clinical Study ◽

Platelet Rich Fibrin ◽

Anterior Teeth ◽

Regenerative Endodontic Treatment

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Platelet-Rich Fibrin Used in Regenerative Endodontics and Dentistry: Current Uses, Limitations, and Future Recommendations for Application

International Journal of Dentistry ◽

10.1155/2021/4514598 ◽

2021 ◽

Vol 2021 ◽

pp. 1-8

Author(s):

Sohaib Arshad ◽

Fatima Tehreem ◽

Muhammad Rehab khan ◽

Fatima Ahmed ◽

Anand Marya ◽

...

Keyword(s):

Bone Growth ◽

Cell Attachment ◽

Platelet Rich Plasma ◽

Blood Clot ◽

Permanent Teeth ◽

Clinical Practices ◽

Platelet Rich Fibrin ◽

Regenerative Endodontics

Regenerative endodontics has introduced numerous procedures such as pulp implantation, revascularization, and postnatal stem cell therapy. Revascularization has been successfully implemented clinically nowadays, thus providing dentists with outrageous results. Platelet-rich fibrin (PRF) used either alone or along with bone graft promotes bone growth and vascularization. This matrix promotes migration, cell attachment, and proliferation of osteoblast that leads to bone formation. PRF consists of a packed fibrin complex consisting of leukocytes, cytokines, and glycoproteins such as thrombospondin. The usage of PRF has reported high success rates in surgical cases such as sinus lift procedures, healing of extraction sockets, and management of periapical abscesses. Compared to platelet-rich plasma, PRF is more economical, easy to prepare, and feasible to use in daily clinical practices. Revascularization compromised the induction of a blood clot into the root canal space, which emerged as a clinical triumph. This further led to platelet concentrates as an autologous scaffold on which revascularization could occur. The applications of PRF in regenerative endodontics are numerous, such as an agent for repairing iatrogenic perforation of the pulpal floor and for the revascularization of immature permanent teeth with necrotic pulps. It acts as a matrix for tissue ingrowth. Evidence of progressive thickening of dentinal walls, root lengthening, regression in the periapical lesion, and apical closure was reported. Further studies are needed to clarify the precise mechanism of action of PRF for dental pulp regeneration both in vitro and in vivo. The current review aims at the present uses of PRF in regenerative endodontics dentistry and its application with future recommendations and limitations.

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