Metastases to Supramandibular Facial Lymph Nodes in Patients With Squamous Cell Carcinoma of the Oral Cavity

2009 ◽  
Vol 67 (7) ◽  
pp. 1401-1408 ◽  
Author(s):  
Vassilis Petsinis ◽  
Nikolaos Papadogeorgakis ◽  
Ioulia Evangelou ◽  
Lampros Goutzanis ◽  
Ekaterini Pandelidaki ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Squamous Cell

scholarly journals Frequency of metastasis to posterior triangle and lower deep jugular lymph nodes in patients with squamous cell carcinoma of oral cavity having clinically N1 neck

2019 ◽  
Vol 5 (5) ◽  
pp. 1286
Author(s):  
Shilpa Varchasvi ◽  
Azeem Moyihuddin
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Oral Cavity ◽  
Lymph Nodes ◽  
Prospective Study ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Buccal Mucosa ◽  
Research Centre ◽  
Posterior Triangle

<p class="abstract"><strong>Background:</strong> Oral cancer is the sixth most common cancer in the world and is largely preventable. The objective of the study is to find out the frequency of metastasis to posterior triangle lymph nodes and lower deep jugular (supraclavicular) lymph nodes in patients with squamous cell carcinoma of oral cavity having clinically N<sub>1 </sub>neck.</p><p class="abstract"><strong>Methods:</strong> A hospital based prospective study.<strong> </strong>This prospective study was conducted in R. L. Jalappa Hospital and Research Centre and SDU Medical College Kolar, Karnataka. 30 patients having oral squamous cell carcinoma with clinically N<sub>1 </sub>neck (single ipsilateral lymph node less than 3cms in diameter) undergoing modified radical neck dissection in R. L. Jalappa Hospital and Research Centre.  </p><p class="abstract"><strong>Results:</strong> In our study, 4 were male (13%) and 26 were females (87%). The age of the patients ranged from 41-70 years with a mean age of 53 years.<strong> </strong>Majority of primary tumours were buccal mucosa tumours (24). We had 6 anterior 2/3<sup>rd</sup> tongue tumours. The primary tumour staging included 17 T<sub>2 </sub>lesions (57%), 3 T<sub>3 </sub>lesions (10%), 10 T<sub>4 </sub>lesions (33%) in patients with buccal mucosa carcinoma, fourteen patients had T<sub>2 </sub>disease, 9 patients had T<sub>4</sub> and one patient had T<sub>3</sub> disease.</p><p class="abstract"><strong>Conclusions:</strong> Most common nodal involvement in buccal mucosa carcinoma was level Ib (submandibular lymph node). The incidence of level IV (supraclavicular) and level V (posterior triangle) lymph node metastasis is low in buccal mucosa carcinoma patients with clinically N<sub>1</sub> neck.</p>

scholarly journals Regional metastasis to anatomies beyond traditional neck dissection boundaries: a multi-institutional analysis focused on unconventional metastases in oral cancer patients

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Weijin Gao ◽  
Zhuowei Tian ◽  
Xiaodan Fang ◽  
Jincai Xue ◽  
Zhixiang Li ◽  
...  
Keyword(s):  
Overall Survival ◽  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Metastatic Lymph Nodes ◽  
Extranodal Extension ◽  
Regional Metastasis ◽  
Metastatic Lymph

Abstract Background Regional metastasis sometimes occurs in anatomies that are not included in traditional neck dissections. The purpose of this study was to evaluate the treatment outcomes of squamous cell carcinoma of oral cavity (SCCOC) patients with unconventional metastatic lymph nodes (UMLNs) in sublingual, buccinator, and parotid anatomies. Methods This retrospective multi-institutional analysis of squamous cell carcinoma of oral cavity patients with unconventional metastatic lymph nodes was performed from January 2008 to December 2015. All the included patients received surgical treatment for unconventional metastatic lymph nodes. The end point of the study was to determine the factors influencing these patients’ survival and the corresponding solutions to improve survival. Pathological grade, contralateral metastasis, extranodal extension, and other factors were collected and analyzed by logistic regression and the Cox model. Results A total of 89 patients were identified. Among these patients, 25 (28.1%) received primary treatment, 28 (31.5%) received staged (therapeutic) neck dissections, and 36 (40.4%) had recurrent or residual diseases. Altogether, 45 patients (51%) had buccinator node metastases, 31 (35%) had sublingual metastases, 12 (14%) had parotid metastases, and 1 had both buccinator and parotid metastases. Regarding regional metastases, 31 patients (34.8%) had isolated unconventional metastatic lymph nodes. Adjuvant therapies were administered to 72 (80.9%) patients, 25 (28.1%) of whom were treated with radio-chemotherapies. The overall survival rate was 38.2%. Multivariate analysis found that the subsites of unconventional metastatic lymph nodes (P = 0.029), extranodal extension in both unconventional metastatic lymph nodes (P = 0.025) and cervical lymph nodes (P = 0.015), sites of primary or recurrent squamous cell carcinoma of oral cavity (P = 0.035), and types of neck dissections (P = 0.025) were significantly associated with overall survival. Conclusions Unconventional metastatic lymph nodes are uncommon, yet awareness of potential unconventional metastatic lymph nodes should be heightened. Early surgical interventions are warranted in patients with sublingual or buccinator metastases, while caution should be given to those with parotid metastases. Aggressive en bloc (in-continuity) resections may be mandatory in advanced oral cancer cases for close anatomic locations with possible buccal or sublingual metastases.

scholarly journals Study of microscopic neck metastasis in clinically N0 neck in oral squamous cell carcinoma

2021 ◽  
Vol 43 (3) ◽  
pp. 293-299
Author(s):  
Nikzad Shahidi ◽  
Nastaran Zokaei
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Significant Relationship ◽  
Cervical Lymph Nodes ◽  
Metastatic Lymph Nodes ◽  
N0 Neck ◽  
Metastatic Lymph

Background: Metastasis of aerodigestive tract cancers to cervical lymph nodes is one of the otolaryngologists’ concerns that relies on a variety of factors such as the size of the primary tumor and its spread. We aimed to study the prevalence of occult cervical metastases in patients with clinical N0 neck in oral cavity squamous cell carcinoma. Methods: In this cross-sectional analytic study, the researchers referred to the archive of Emam Reza Hospital and studied medical files of patients with a definite diagnosis of oral cavity squamous cell carcinoma admitted from April 2011 to April 2016 while collecting relevant data such as age, gender, size of the primary mass, place of the lesion, clinical and pathological nodal involvement. The data was analyzed employing SPSS 19 whereas the statistical significance level in all exams was set at 0.05. Results: Average age of participants was 61.67 ± 14.02, and they were mostly male. Forty-five percent of participants had a clinical N0 neck and the majority of them didn’t have metastasis in the pathological study. The prevalence of metastatic lymph nodes in patients with clinical N0 was 30%. No significant relationship was observed between the number of lymph nodes containing occult metastasis and T of the tumor (P = .578). Conclusion: In squamous cell carcinoma of oral cavity, the prevalence of metastatic lymph nodes in the neck is 30% and is significantly related to the location of the lesion while no significant relationship to T of the tumor is observed.

scholarly journals VIMENTIN EXPRESSION AND ITS CORRELATION WITH LYMPH NODE METASTASIS IN ORAL SQUAMOUS CELL CARCINOMA

2021 ◽  
Vol 10 (4) ◽  
pp. 3442-3445
Author(s):  
Anmol Taneja
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Oral Cavity ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Mesenchymal Cells ◽  
Node Metastasis

Squamous cell carcinoma and Adenocarcinoma are common subtypes of carcinoma of oral cavity. More than six lakh cases of cancers of head and neck are being diagnosed globally every year and worldwide, it’s the 6th most common cancer. Head and Neck cancers mostly take origin from epithelial lining of oral cavity, oropharynx, larynx and hypopharynx and 90% of them morphologically is predominantly squamous cell carcinoma. OSCC has a poor prognosis, the reason being metastasis to lymph nodes and its recurrence. So, the identification of specific markers with metastasis to lymph nodes should be done for early and specific diagnosis. Normal and neoplastic mesenchymal cells contain vimentin as major protein constituent of intermediate filaments. Vimentin does not show expression usually in non-neoplastic epithelial cells, but shows expression in mesenchymal cells. Vimentin as a marker of epithelial to mesenchymal transitionis used in diagnosing lymph node metastasis in cases of OSCC.

Oral cavity squamous cell carcinoma metastatic to central compartment (level 6) lymph nodes

2015 ◽  
Vol 126 (8) ◽  
pp. 1803-1805 ◽  
Author(s):  
Ilya Likhterov ◽  
Meghan E. Rowe ◽  
Azita S. Khorsandi ◽  
Mark L. Urken
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Central Compartment
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