A Retrospective Cross-Sectional Study of the Effect of Liposomal Bupivacaine on Postoperative Opioid Prescribing After Third Molar Extraction

In the human being, third molar is the tooth that exhibits more variants during its embryologic development, usually causing diverse anomalies and discomfort when erupting to the oral cavity. It has been pointed out that the prevalence of third molar agenesis is between 9 to 37%. The aim of the present comparative cross-sectional study was to radiographically assess the presence/absence of third molar germs (G3M) in a sample of pediatric patients of Mexican origin. A total of 513 panoramic radiographs were analyzed from patients attending the Pediatric Dentistry Postgraduate Program ( San Luis Potosí University, México), during the years 2011 to 2017. Inclusion criteria were patients between 7 and 18 years old, any gender; children with antecedents of a third molar extraction, previous orthodontic treatment, or with an associated congenital or systemic condition were excluded. Total prevalence G3M agenesis was calculated. Then, statistical comparisons of agenesia proportions per dental quadrant, gender, and age group were performed. 245 panoramic radiographs corresponded to the female gender, while 268 belonged to the male gender. The total prevalence of G3M agenesia was estimated in nearly 56%, and the 7-8 years old group exhibited the highest proportion; however, when this age group was excluded from the analysis, such prevalence decreased to 27.3%. Both mandibular quadrants showed higher proportions of G3M agenesia. There were no significant differences between genders. The total prevalence reported in the present study was found to be well above regarding the international parameters. It is quite possible that lack of radiographic visualization of G3M had been inaccurate in some cases due to the common absence of calcification traces from those teeth during early ages (7-8 years old). The adjusted analysis provided a prevalence value more in line with the recognized standards in the dental literature.

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Increasing tramadol utilisation under strict regulatory control of opioid prescribing – A cross-sectional study in Taiwan from 2002 through 2016

Journal of the Formosan Medical Association ◽

10.1016/j.jfma.2020.09.011 ◽

2020 ◽

Cited By ~ 1

Author(s):

Teng-Chou Chen ◽

Ting-Chun Wang ◽

Chih-Peng Lin ◽

Kerina Bonar ◽

Darren M. Ashcroft ◽

...

Keyword(s):

Cross Sectional Study ◽

Regulatory Control ◽

Sectional Study ◽

Cross Sectional ◽

Opioid Prescribing

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Comment on “Investigation of an Opioid Prescribing Protocol After Third Molar Extraction Procedures”

Journal of Oral and Maxillofacial Surgery ◽

10.1016/j.joms.2019.03.027 ◽

2019 ◽

Vol 77 (7) ◽

pp. 1322

Author(s):

Brent L. Florine

Keyword(s):

Third Molar ◽

Extraction Procedures ◽

Opioid Prescribing ◽

Third Molar Extraction ◽

Molar Extraction

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Liposomal Bupivacaine Use in Third Molar Impaction Surgery: INNOVATE Study

Anesthesia Progress ◽

10.2344/anpr-64-02-03 ◽

2017 ◽

Vol 64 (3) ◽

pp. 127-135 ◽

Cited By ~ 9

Author(s):

Stuart E. Lieblich ◽

Hassan Danesi

Keyword(s):

Third Molar ◽

Controlled Study ◽

Primary Efficacy ◽

Liposomal Bupivacaine ◽

Time Points ◽

Third Molar Extraction ◽

Pain Scores ◽

Protocol Population ◽

Efficacy Population ◽

Molar Extraction

The analgesic efficacy and safety of liposomal bupivacaine (LB) in third molar extraction was evaluated in this phase 3, double-blind, placebo-controlled study of subjects undergoing bilateral third molar extraction. Subjects were randomized 2 : 1 to infiltration with LB (133 mg/10 mL) or placebo, and received opioid rescue medication as needed. Primary efficacy measure was cumulative area under the curve (AUC) of numeric rating scale (NRS) pain severity scores through 48 hours (AUC of NRS0–48) postsurgery. Other measures included AUC of NRS0–24, AUC of NRS0–72, and AUC of NRS0–96, and incidence of adverse events. There were 150 subjects in the primary efficacy population (n = 99 LB, n = 51 placebo) and 89 in the per-protocol population (n = 59 LB, n = 30 placebo). Least-squares mean for AUC of NRS0–48 was 172.3 LB versus 194.7 placebo (P = .227) in the primary efficacy population and 120.8 LB versus 183.3 placebo (P = .023) in the per-protocol population. At all time points, between-group differences in AUC of NRS scores were significant in the per-protocol population (LB lower than placebo, P < .05) but not in the primary efficacy population. The adverse event profile was similar between groups. LB produced significantly lower cumulative pain scores versus placebo at all time points in the per-protocol analysis but not in the primary efficacy analysis because of protocol violations. This study indicates significant improvement in pain scores in the third molar model, but because of extensive protocol violations additional studies are warranted to demonstrate effectiveness.

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Factors predictive of the intensity of local anesthesia in mandibular third-molar surgery: A cross-sectional study

Journal of Stomatology Oral and Maxillofacial Surgery ◽

10.1016/j.jormas.2019.09.004 ◽

2020 ◽

Vol 121 (2) ◽

pp. 107-112

Author(s):

M.H. Al-Shayyab ◽

Z.H. Baqain

Keyword(s):

Local Anesthesia ◽

Third Molar ◽

Cross Sectional Study ◽

Third Molar Surgery ◽

Sectional Study ◽

Cross Sectional ◽

Mandibular Third Molar ◽

Mandibular Third Molar Surgery

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Association of Oral Hygiene and Periodontal Health with Third Molar Pericoronitis: A Cross-Sectional Study

BioMed Research International ◽

10.1155/2021/6664434 ◽

2021 ◽

Vol 2021 ◽

pp. 1-7

Author(s):

Mehmet Gagari Caymaz ◽

Oğuz Buhara

Keyword(s):

Health Status ◽

Oral Hygiene ◽

Dental Plaque ◽

Third Molar ◽

Cross Sectional Study ◽

Sectional Study ◽

Periodontal Health ◽

Cross Sectional ◽

Impacted Third Molar ◽

Molar Teeth

Background. Pericoronitis is a painful inflammatory condition commonly associated with third molar teeth. The purpose of this study was to investigate the relationship between oral hygiene and periodontal health status and the presence of pericoronitis in semi-impacted third molar teeth. Methods. A cross-sectional study was conducted, and 54 patients having at least one mandibular vertically semi-impacted third molar tooth with or without pericoronitis were consecutively enrolled. Subjects with pericoronitis and subjects with healthy third molars were selected according to symptoms in the gingiva overlying semi-impacted third molar teeth. Periodontal health status and oral hygiene were evaluated with the measures of plaque index (PI), gingival index (GI), and total number of sites with a probing depth PD ≥ 4 mm . The clinical data collected in this study was analyzed with Mann–Whitney U test using SPSS 20.0 package program. Results. The PI scores were found to be significantly higher in patients with pericoronitis ( p < 0.05 ). Although the GI scores and PD scores were higher in patients with pericoronitis, the difference did not reach statistical significance when compared with those in healthy subjects ( p > 0.05 ). Conclusion. The findings obtained in this study suggest that the amount of dental plaque was positively associated with third molar pericoronitis. Gingival and periodontal health conditions were similar between patients with and without pericoronitis. Improving oral hygiene and controlling dental plaque may help prevent third molar pericoronitis.

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Reasons and patterns for tooth extraction among patients presenting at a hospital of stomatology in Guangzhou, China: A cross-sectional study

10.21203/rs.3.rs-30798/v1 ◽

2020 ◽

Author(s):

Hongyu Li ◽

Zhiguo Liu ◽

Dongsheng Yu ◽

Haikuo Tang

Keyword(s):

Tooth Extraction ◽

Periodontal Diseases ◽

Age Groups ◽

Third Molar ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Posterior Teeth ◽

Old Patients ◽

Anterior Teeth

Abstract Background Few related surveys about reasons for tooth extraction was shown in mainland China. Our aim was to investigate the primary reasons and main pattern for extractions among patients presenting at a hospital of stomatology in Guangzhou, China. Methods This descriptive cross-sectional study was conducted over a period of 3 months, 2000 patients who underwent tooth extraction were recorded and analyzed by age, gender, the tooth type and the extraction reasons. Chi-square test was used to examine the differences in the extraction reasons between different genders, age groups and tooth types. Results A total of 3106 teeth were removed from 2000 patients, with an age ranging from 6 to 91. This study revealed details of extraction reasons and suggested that dental caries (25.42%) was the main reasons for tooth extraction and pointed out preventive extraction of third molar (19.89%) had displaced periodontal diseases (12.89%) as the dominant reason for extractions. Overall, third molar was the most frequently extracted tooth (1567). Significant statistical differences were found among different age groups, genders and tooth types for tooth extraction reasons (p༜0.05). For example, caries was the main reason for tooth extraction in 30–59 years old patients, while 20–29 years old patients asked for preventive extraction of third molar teeth mostly. Posterior teeth were mostly removed because of caries and periodontal disease was the leading cause for anterior teeth extraction. Conclusions We found the primary reasons and the new patterns for tooth extraction among patients in Guangzhou. It was proposed for the first time that the dominant reason for extractions was preventive extraction of third molar. Our finding could help to put forward some predictors and adjust the preventive strategies in oral disorders.

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