Validated determination of losartan and valsartan in human plasma by stir bar sorptive extraction based on acrylate monolithic polymer, liquid chromatographic analysis and experimental design methodology

2018 ◽  
Vol 153 ◽  
pp. 204-213 ◽  
Author(s):  
Vida Babarahimi ◽  
Zahra Talebpour ◽  
Farideh Haghighi ◽  
Nuoshin Adib ◽  
Hamed Vahidi
Keyword(s):  
Experimental Design ◽  
Human Plasma ◽  
Chromatographic Analysis ◽  
Design Methodology ◽  
Stir Bar Sorptive Extraction ◽  
Sorptive Extraction ◽  
Liquid Chromatographic Analysis ◽  
Liquid Chromatographic ◽  
Experimental Design Methodology

Development of an optimized HPLC method for the simultaneous determination of six compounds containing β-lactam ring in human plasma and urine using experimental design methodology

RSC Advances ◽  
2016 ◽  
Vol 6 (12) ◽  
pp. 9465-9474 ◽  
Author(s):  
Eman A. Abdel Hameed ◽  
Randa A. Abdel Salam ◽  
Ghada M. Hadad
Keyword(s):  
Experimental Design ◽  
Simultaneous Determination ◽  
Human Plasma ◽  
Design Methodology ◽  
Chromatographic Method ◽  
Biological Fluids ◽  
Hplc Method ◽  
Lactam Ring ◽  
Experimental Design Methodology

β-Lactam antibiotics are commonly prescribed with β-lactamase inhibitors to patients, for that it is necessary to develop an optimized chromatographic method which determine them simultaneously in biological fluids.

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