Chitosan coated magnetic nanoparticles as carriers of anticancer drug Telmisartan: pH-responsive controlled drug release and cytotoxicity studies

2021 ◽  
Vol 148 ◽  
pp. 109749 ◽  
Author(s):  
Rushikesh P. Dhavale ◽  
R.P. Dhavale ◽  
S.C. Sahoo ◽  
P. Kollu ◽  
S.U. Jadhav ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Drug Release ◽  
Anticancer Drug ◽  
Controlled Drug Release ◽  
Ph Responsive ◽  
Cytotoxicity Studies

scholarly journals Carbon-Based Magnetic Nanocarrier for Controlled Drug Release: A Green Synthesis Approach

2018 ◽  
Vol 5 (1) ◽  
pp. 1 ◽  
Author(s):  
Jessica Oliveira ◽  
Raquel Rodrigues ◽  
Lillian Barros ◽  
Isabel Ferreira ◽  
Luís Marchesi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Drug Release ◽  
Phosphate Buffer ◽  
Colloidal Stability ◽  
Ph Dependence ◽  
Phosphate Buffer Solution ◽  
Controlled Drug Release ◽  
Buffer Solution ◽  
Carbon Based

In this study, hydrophilic magnetic nanoparticles were synthesized by green routes using a methanolic extract of Rubus ulmifolius Schott flowers. The prepared magnetic nanoparticles were coated with carbon-based shell for drug delivery application. The nanocomposites were further chemically functionalized with nitric acid and, sequentially, with Pluronic® F68 (CMNPs-plur) to enhance their colloidal stability. The resulting material was dispersed in phosphate buffer solution at pH 7.4 to study the Doxorubicin loading. After shaking for 48 h, 99.13% of the drug was loaded by the nanocomposites. Subsequently, the drug release was studied in different working phosphate buffer solutions (i.e., PB pH 4.5, pH 6.0 and pH 7.4) to determine the efficiency of the synthesized material for drug delivery as pH-dependent drug nanocarrier. The results have shown a drug release quantity 18% higher in mimicking tumor environment than in the physiological one. Therefore, this study demonstrates the ability of CMNPs-plur to release a drug with pH dependence, which could be used in the future for the treatment of cancer "in situ" by means of controlled drug release.

Molecular encapsulator on the surface of magnetic nanoparticles. Controlled drug release from calcium Ferrite/Cyclodextrin–tethered polymer hybrid

2018 ◽  
Vol 161 ◽  
pp. 347-355 ◽  
Author(s):  
Sivaraj Ramasamy ◽  
Beniya Samathanam ◽  
Helfried Reuther ◽  
Muthukumar Nadar Meenakshi Subbaraman Adyanpuram ◽  
Israel Vijayaraj Muthu Vijayan Enoch ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Drug Release ◽  
Controlled Drug Release ◽  
Calcium Ferrite ◽  
Polymer Hybrid

Monoolein Cubic Phase Gels and Cubosomes Doped with Magnetic Nanoparticles–Hybrid Materials for Controlled Drug Release

2017 ◽  
Vol 9 (3) ◽  
pp. 2796-2805 ◽  
Author(s):  
Monika Szlezak ◽  
Dorota Nieciecka ◽  
Aleksandra Joniec ◽  
Marek Pękała ◽  
Ewa Gorecka ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Drug Release ◽  
Hybrid Materials ◽  
Controlled Drug Release ◽  
Cubic Phase

Photo-cross-linked biodegradable thermo- and pH-responsive hydrogels for controlled drug release

2011 ◽  
Vol 123 (5) ◽  
pp. 2923-2932 ◽  
Author(s):  
Changwen Zhao ◽  
Pan He ◽  
Chunsheng Xiao ◽  
Xiaoye Gao ◽  
Xiuli Zhuang ◽  
...  
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Ph Responsive ◽  
Responsive Hydrogels

pH-Responsive polymeric Janus containers for controlled drug delivery

2015 ◽  
Vol 6 (22) ◽  
pp. 4144-4153 ◽  
Author(s):  
Ziguang Zhao ◽  
Feiyan Zhu ◽  
Xiaozhong Qu ◽  
Qiuhua Wu ◽  
Qian Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Hollow Spheres ◽  
Controlled Drug Delivery ◽  
Controlled Drug Release ◽  
Ph Responsive

In this study, we have successfully designed and fabricated pH-responsive polymeric Janus hollow spheres for controlled drug release.

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