Low Iron Storage in Children and Adolescents with Neurally Mediated Syncope

Abstract Background Vasovagal syncope (VVS) is a kind of common neurally mediated syncope in children and adolescents. Decreased blood volume is one of the pathogenesis of VVS. The diagnosis of VVS is mainly based on head-up tilt test (HUTT), but some complications may easily occur when HUTT induces syncope. To find a simple and safe VVS diagnosis method can improve the VVS diagnosis efficiency. Aims of the study This was a prospective study. The study will explore the predictive value of urine specific gravity (USG) in the diagnosis of VVS in children and adolescents. Patients and methods Ninety-seven cases (43 males and 54 females, aged 4 to 16 years old, with an average age of 10.91 ± 2.18 years old) hospitalized due to unexplained premonitory syncope or syncope and diagnosed with VVS through HUTT from September 2014 to September 2018 were selected as VVS group. During the same period, 91 cases of children and adolescents, including 45 males and 46 females, aged from 5 to 15 years old, who underwent a healthy examination were matched as a control (control group). USG was measured in both groups. Results The USG of VVS group was significantly lower than that of the control group (P < 0.01), and USG of females was lower than that of males in VVS group (P = 0.045). The sensitivity and specificity of USG in predicting VVS were evaluated by ROC curve. The area under the ROC curve was 0.751, standard error was 0.035, and 95% CI (0.683, 0.819) suggested that USG was of moderate predictive value in the diagnosis of VVS. As cut-off value of USG was 1.0185, the sensitivity and specificity and diagnostic coincidence rate of VVS were 74.39, 66.04 and 69.68%, respectively. Conclusion There are less USG in children and adolescents with VVS, especially lower USG in females. Therefore, USG has predictive value in the diagnosis of VVS in children and adolescents.

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Low iron storage in children with tilt positive neurally mediated syncope

World Journal of Pediatrics ◽

10.1007/s12519-012-0396-7 ◽

2012 ◽

Vol 9 (2) ◽

pp. 146-151 ◽

Cited By ~ 4

Author(s):

Baris Guven ◽

Taliha Oner ◽

Vedide Tavli ◽

Murat Muhtar Yilmazer ◽

Savas Demirpence ◽

...

Keyword(s):

Iron Storage ◽

Neurally Mediated Syncope

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225 Repeated tilt testing in children and adolescents with tilt-positive neurally mediated syncope

EP Europace ◽

10.1016/eupace/7.supplement_1.46 ◽

2005 ◽

Vol 7 (Supplement_1) ◽

pp. 46-46

Author(s):

H. Ector ◽

H. Heidb chel ◽

R. Willems ◽

T. Reybrouck

Keyword(s):

Children And Adolescents ◽

Tilt Testing ◽

Neurally Mediated Syncope

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Polygonal profiles of ferritin molecules

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100076603 ◽

1983 ◽

Vol 41 ◽

pp. 600-601

Author(s):

William H. Massover

Keyword(s):

Axial Ratio ◽

X Ray Diffraction ◽

Rhombic Dodecahedron ◽

Apparent Contradiction ◽

Iron Storage ◽

X Ray ◽

Hexagonal Shape ◽

Axes Of Symmetry ◽

Apparent Conflict ◽

Iron Storage Protein

The molecular structure of the iron-storage protein, ferritin, is becoming known in ever finer detail. The 24 apoferritin subunits (MW ca. 20,000) have a 2:1 axial ratio and are polymerized with 4:3:2 symmetry to form an outer shell surrounding a variable amount of microcrystalline iron, Recent x-ray diffraction results indicate that the projected outline of the native molecule has a quasi-hexagonal shape when viewed down the 3-fold axes of symmetry, and a quasi-square shape when looking down the 4-fold axes. To date, no electron microscope study has reported observing anything other than circular profiles, which would indicate that ferritin is strictly spherical. The apparent conflict between the "hollow sphere" of electron microscopy (E.M.) and the "truncated rhombic dodecahedron" of x-ray diffraction could reflect the poorer effective resolution of E.M. coming from radiation damage, staining, drying, etc. The present study investigates the detailed shape of individual ferritin molecules in order to search for the predicted aspherical profiles and to interpret the nature of this apparent contradiction.

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Iron storage sites in the myocardium as revealed by cytohistochemistry

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100104030 ◽

1988 ◽

Vol 46 ◽

pp. 394-395

Author(s):

M. Ashraf ◽

F. Thompson ◽

S. Miki ◽

P. Srivastava

Keyword(s):

Cardiac Tissue ◽

Coronary Perfusion ◽

Intracellular Iron ◽

Ether Anesthesia ◽

Intense Staining ◽

Iron Storage ◽

Thin Sections ◽

Rat Hearts ◽

Cacodylate Buffer ◽

Made In

Iron is believed to play an important role in the pathogenesis of ischemic injury. However, the sources of intracellular iron in myocytes are not yet defined. In this study we have attempted to localize iron at various cellular sites of the cardiac tissue with the ferrocyanide technique.Rat hearts were excised under ether anesthesia. They were fixed with coronary perfusion with 3% buffered glutaraldehyde made in 0.1 M cacodylate buffer pH 7.3. Sections, 60 μm in thickness, were cut on a vibratome and were incubated in the medium containing 500 mg of potassium ferrocyanide in 49.5 ml H2O and 0.5 ml concentrated HC1 for 30 minutes at room temperature. Following rinses in the buffer, tissues were dehydrated in ethanol and embedded in Spurr medium.The examination of thin sections revealed intense staining or reaction product in peroxisomes (Fig. 1).

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Analyzing the Potential Benefit of Microcomputer Use for Teaching Figurative Language

American Journal of Speech-Language Pathology ◽

10.1044/1058-0360.0102.36 ◽

1992 ◽

Vol 1 (2) ◽

pp. 36-43 ◽

Cited By ~ 5

Author(s):

Marilyn A. Nippold ◽

Ilsa E. Schwarz ◽

Molly Lewis

Keyword(s):

Language Learning ◽

Children And Adolescents ◽

Standardized Tests ◽

Figurative Language ◽

Language Intervention ◽

School Age Children ◽

Educational Materials ◽

Language Learning Disabilities ◽

Promising Application ◽

Experience Difficulty

Microcomputers offer the potential for increasing the effectiveness of language intervention for school-age children and adolescents who have language-learning disabilities. One promising application is in the treatment of students who experience difficulty comprehending figurative expressions, an aspect of language that occurs frequently in both spoken and written contexts. Although software is available to teach figurative language to children and adolescents, it is our feeling that improvements are needed in the existing programs. Software should be reviewed carefully before it is used with students, just as standardized tests and other clinical and educational materials are routinely scrutinized before use. In this article, four microcomputer programs are described and evaluated. Suggestions are then offered for the development of new types of software to teach figurative language.

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