Lactobacillus reuteri (DSM 17938) in Infants with Functional Chronic Constipation: A Double-Blind, Randomized, Placebo-Controlled Study

The efficacy of oral rehydration solution (ORS) enriched with Lactobacillus reuteri DSM 17938 and zinc in infants with acute gastroenteritis, is poorly defined. The aim of this double-blind, randomized, placebo-controlled study, was to assess the efficacy of an ORS enriched with Lactobacillus reuteri DSM 17938 and zinc (ORS+Lr&Z) in well-nourished, non-hospitalized infants with acute diarrhoea. Fifty one infants with acute diarrhoea were randomly assigned to receive either ORS+Lr&Z (28 infants, mean ± SD age 1.7 ± 0.7 years, 21 males), or standard ORS (ORS−Lr&Z; 23 infants, mean ± SD age 1.8 ± 0.7 years, 16 males). Stools volume and consistency were recorded pre- and posttreatment using the Amsterdam Infant Stool Scale and were compared between the two groups, as well as lost work/day care days, drug administration and need for hospitalization. Both groups showed reduction in the severity of diarrhoea on day two (p < 0.001) while, all outcomes showed a trend to be better in the ORS+Lr&Z group, without reaching statistical significance, probably due to the relatively small number of patients. No adverse effects were recorded. In conclusion, both ORS were effective in managing acute diarrhoea in well-nourished, non-hospitalized infants. ORS enriched with L. reuteri DSM 17938 and zinc was well tolerated with no adverse effects.

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Role of probiotics in lower reproductive tract infection in women of age group 18 to 45 years

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20170404 ◽

2017 ◽

Vol 6 (2) ◽

pp. 671

Author(s):

Rukshana Shamshu ◽

Jayasree Vaman ◽

Nirmala C.

Keyword(s):

Bacterial Vaginosis ◽

Lactobacillus Reuteri ◽

Lactobacillus Rhamnosus ◽

Vulvovaginal Candidiasis ◽

Controlled Study ◽

Control Group ◽

P Value ◽

Double Blind ◽

Reproductive Tract Infection ◽

Conventional Antibiotics

Background: This study has been designed to assess the effectiveness of the probiotic strains having Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 in the management of lower genital infections (bacterial vaginosis and candidiasis) as an integral therapy with antibiotics.Methods: Double blind, randomized placebo controlled study in women between 18-45 years attending Sree Avittom Thirunal Hospital (SATH), Government Medical College, Thiruvananthapuram, India with symptoms of bacterial vaginosis and vulvovaginal candidiasis. Women giving consent were given probiotics along with conventional antibiotics and were followed up over a period of two months. Outcome is measured as percentage of women showing a score of less than 4 at the end of thirty days of treatment, and sixty days of treatment in the test and control group in the case of bacterial vaginosis and no discharge and absence of hyphae and pseudohyphae in wet smear and gram stain in case of candidiasis.Results: Out of 42 women studied, 32 had bacterial vaginosis and 10 had vulvovaginal candidiasis. 81.3% women with BV had a normal vaginal picture after sixty days of treatment as compared to placebo which was only 31.3%. The p value is 0.004 which is significant. In the treatment of VC, the percentage of women cured was the same in both probiotic and placebo group.Conclusions: In the treatment of bacterial vaginosis, addition of probiotics to the conventional antibiotics can improve the cure rate of bacterial vaginosis and reduce the rate of recurrences. In the treatment of vulvovaginal candidiasis, addition of probiotics to the conventional antifungal did not have a significant improvement.

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Linaclotide Significantly Improved Bowel Habits and Relieved Abdominal Symptoms in Adults with Chronic Constipation: Data from a Large 4-Week, Randomized, Double-Blind, Placebo-Controlled Study

Gastroenterology ◽

10.1053/j.gastro.2008.05.062 ◽

2008 ◽

Vol 135 (1) ◽

pp. 295 ◽

Cited By ~ 4

Author(s):

Anthony J. Lembo ◽

Jeffrey M. Johnston ◽

James E. MacDougall ◽

Bernard J. Lavins ◽

Donald A. Fitch ◽

...

Keyword(s):

Chronic Constipation ◽

Controlled Study ◽

Double Blind ◽

Double Blind Placebo ◽

Bowel Habits ◽

Abdominal Symptoms

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Dose-finding study of linaclotide in Japanese patients with chronic constipation: A phase II randomized, double-blind, and placebo-controlled study

Neurogastroenterology & Motility ◽

10.1111/nmo.13442 ◽

2018 ◽

Vol 30 (12) ◽

pp. e13442 ◽

Cited By ~ 3

Author(s):

Shin Fukudo ◽

Hiroto Miwa ◽

Atsushi Nakajima ◽

Yoshikazu Kinoshita ◽

Masanori Kosako ◽

...

Keyword(s):

Phase Ii ◽

Chronic Constipation ◽

Japanese Patients ◽

Dose Finding ◽

Controlled Study ◽

Double Blind ◽

Finding Study ◽

Dose Finding Study

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Effect of yogurt containing polydextrose, Lactobacillus acidophilus NCFM and Bifidobacterium lactis HN019: a randomized, double-blind, controlled study in chronic constipation

Nutrition Journal ◽

10.1186/1475-2891-13-75 ◽

2014 ◽

Vol 13 (1) ◽

Cited By ~ 29

Author(s):

Daniéla Oliveira Magro ◽

Lais Mariana R de Oliveira ◽

Isabela Bernasconi ◽

Marilia de Souza Ruela ◽

Laura Credidio ◽

...

Keyword(s):

Lactobacillus Acidophilus ◽

Chronic Constipation ◽

Controlled Study ◽

Double Blind ◽

Bifidobacterium Lactis ◽

Lactobacillus Acidophilus Ncfm

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Lactobacillus reuteri DSM 17938 and Agave Inulin in Children with Cerebral Palsy and Chronic Constipation: A Double-Blind Randomized Placebo Controlled Clinical Trial

Nutrients ◽

10.3390/nu12102971 ◽

2020 ◽

Vol 12 (10) ◽

pp. 2971

Author(s):

Andrea García Contreras ◽

Edgar Vásquez Garibay ◽

Carmen Sánchez Ramírez ◽

Mary Fafutis Morris ◽

Vidal Delgado Rizo

Keyword(s):

Cerebral Palsy ◽

Placebo Group ◽

Chronic Constipation ◽

Lactobacillus Reuteri ◽

Controlled Clinical Trial ◽

Double Blind ◽

Probiotic Group ◽

Fecal Mass ◽

Children With Cerebral Palsy ◽

History Of

The main objective was to assess the efficacy of a probiotic (Lactobacillus reuteri DSM 17938), a prebiotic (agave inulin), and a synbiotic on the stool characteristics in children with cerebral palsy and chronic constipation. Thirty-seven children with cerebral palsy and chronic constipation were included. The probiotic group received 1 × 108 colony forming unit (cfu) of L. reuteri DSM 17938 plus placebo, the prebiotic group received 4 g of agave inulin plus placebo, the synbiotic group received L. reuteri DSM 17938 plus agave inulin, and the placebo group received two placebos for 28 days. The probiotic group showed a significant decrease in stool pH (p = 0.014). Stool consistency improved in the prebiotic group (p = 0.008). The probiotic, prebiotic, and synbiotic groups showed a significant improvement in the history of excessive stool retention, the presence of fecal mass in the rectum, and the history of painful defecation. L. reuteri concentration in feces was higher in the probiotic group than in the placebo group (p = 0.001) and showed an inverse correlation with stool pH in the probiotic group (r = −0.762, p = 0.028). This study showed that the use of L. reuteri DSM 17938 and/or agave inulin improved the stool characteristics such as the history of painful defecation and the presence of fecal mass in the rectum against placebo in children with cerebral palsy and chronic constipation.

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