Dose-finding study of linaclotide in Japanese patients with chronic constipation: A phase II randomized, double-blind, and placebo-controlled study

Shin Fukudo; Hiroto Miwa; Atsushi Nakajima; Yoshikazu Kinoshita; Masanori Kosako; Ayako Nakagawa; Hiraku Akiho; Kentaro Kuroishi; Jeffrey M. Johnston; Mark Currie; Toshifumi Ohkusa

doi:10.1111/nmo.13442

Dose-finding study of linaclotide in Japanese patients with chronic constipation: A phase II randomized, double-blind, and placebo-controlled study

Neurogastroenterology & Motility ◽

10.1111/nmo.13442 ◽

2018 ◽

Vol 30 (12) ◽

pp. e13442 ◽

Cited By ~ 3

Author(s):

Shin Fukudo ◽

Hiroto Miwa ◽

Atsushi Nakajima ◽

Yoshikazu Kinoshita ◽

Masanori Kosako ◽

...

Keyword(s):

Phase Ii ◽

Chronic Constipation ◽

Japanese Patients ◽

Dose Finding ◽

Controlled Study ◽

Double Blind ◽

Finding Study ◽

Dose Finding Study

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Efficacy and safety of a crystalline lactulose preparation (SK-1202) in Japanese patients with chronic constipation: a randomized, double-blind, placebo-controlled, dose-finding study

Journal of Gastroenterology ◽

10.1007/s00535-018-01545-7 ◽

2019 ◽

Vol 54 (6) ◽

pp. 530-540 ◽

Cited By ~ 4

Author(s):

Kunio Kasugai ◽

Hisakazu Iwai ◽

Noboru Kuboyama ◽

Aya Yoshikawa ◽

Shin Fukudo

Keyword(s):

Chronic Constipation ◽

Japanese Patients ◽

Dose Finding ◽

Efficacy And Safety ◽

Double Blind ◽

Double Blind Placebo ◽

Finding Study ◽

Dose Finding Study

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A randomized, double-blind, placebo-controlled phase II dose-finding study of the novel anti-muscarinic agent imidafenacin in Japanese patients with overactive bladder

International Journal of Urology ◽

10.1111/j.1442-2042.2008.02104.x ◽

2008 ◽

Vol 15 (9) ◽

pp. 809-815 ◽

Cited By ~ 32

Author(s):

Yukio Homma ◽

Takuhiro Yamaguchi ◽

Osamu Yamaguchi

Keyword(s):

Overactive Bladder ◽

Phase Ii ◽

Japanese Patients ◽

Dose Finding ◽

The Novel ◽

Double Blind ◽

Double Blind Placebo ◽

Finding Study ◽

Dose Finding Study

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Dose-Finding of Linaclotide for Patients with Chronic Constipation in Japan: A Phase II Randomized, Double-Blind, and Placebo-Controlled Study

Gastroenterology ◽

10.1016/s0016-5085(17)31900-5 ◽

2017 ◽

Vol 152 (5) ◽

pp. S515-S516

Author(s):

Shin Fukudo ◽

Hiroto Miwa ◽

Atsushi Nakajima ◽

Yoshikazu Kinoshita ◽

Masanori Kosako ◽

...

Keyword(s):

Phase Ii ◽

Chronic Constipation ◽

Dose Finding ◽

Controlled Study ◽

Double Blind

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Efficacy and Safety of the Selective β3-Adrenoceptor Agonist Mirabegron in Japanese Patients with Overactive Bladder: A Randomized, Double-Blind, Placebo-Controlled, Dose-Finding Study

LUTS Lower Urinary Tract Symptoms ◽

10.1111/luts.12053 ◽

2014 ◽

Vol 7 (2) ◽

pp. 84-92 ◽

Cited By ~ 15

Author(s):

Osamu YAMAGUCHI ◽

Eiji MARUI ◽

Yasuhiko IGAWA ◽

Masayuki TAKEDA ◽

Osamu NISHIZAWA ◽

...

Keyword(s):

Overactive Bladder ◽

Japanese Patients ◽

Dose Finding ◽

Efficacy And Safety ◽

Double Blind ◽

Double Blind Placebo ◽

Adrenoceptor Agonist ◽

Finding Study ◽

Dose Finding Study

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Phase 2b study of evocalcet (KHK7580), a novel calcimimetic, in Japanese patients with secondary hyperparathyroidism undergoing hemodialysis: A randomized, double-blind, placebo-controlled, dose-finding study

PLoS ONE ◽

10.1371/journal.pone.0204896 ◽

2018 ◽

Vol 13 (10) ◽

pp. e0204896 ◽

Cited By ~ 7

Author(s):

Tadao Akizawa ◽

Ryutaro Shimazaki ◽

Masafumi Fukagawa ◽

Keyword(s):

Secondary Hyperparathyroidism ◽

Japanese Patients ◽

Dose Finding ◽

Double Blind ◽

Double Blind Placebo ◽

Finding Study ◽

Dose Finding Study

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Effect of the cathepsin K inhibitor odanacatib administered once weekly on bone mineral density in Japanese patients with osteoporosis—a double-blind, randomized, dose-finding study

Osteoporosis International ◽

10.1007/s00198-013-2398-2 ◽

2013 ◽

Vol 25 (1) ◽

pp. 367-376 ◽

Cited By ~ 29

Author(s):

T. Nakamura ◽

M. Shiraki ◽

M. Fukunaga ◽

T. Tomomitsu ◽

A. C. Santora ◽

...

Keyword(s):

Bone Mineral Density ◽

Bone Mineral ◽

Cathepsin K ◽

Japanese Patients ◽

Dose Finding ◽

Mineral Density ◽

Double Blind ◽

Cathepsin K Inhibitor ◽

Finding Study ◽

Dose Finding Study

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A Phase II, double-blind, randomized, parallel group, dose-finding study of the safety and tolerability of darexaban compared with warfarin in patients with non-valvular atrial fibrillation: the oral factor Xa inhibitor for prophylaxis of stroke in atrial

Journal of Thrombosis and Haemostasis ◽

10.1111/jth.13025 ◽

2015 ◽

Vol 13 (8) ◽

pp. 1405-1413 ◽

Cited By ~ 8

Author(s):

G. Y. H. Lip ◽

J. L. Halperin ◽

P. Petersen ◽

G. M. Rodgers ◽

D. Pall ◽

...

Keyword(s):

Atrial Fibrillation ◽

Phase Ii ◽

Factor Xa ◽

Dose Finding ◽

Factor Xa Inhibitor ◽

Double Blind ◽

Parallel Group ◽

Finding Study ◽

Dose Finding Study

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A randomized, double-blind, placebo-controlled, phase II dose-finding study of the short acting β1-blocker, landiolol hydrochloride, in patients with suspected ischemic cardiac disease

The International Journal of Cardiovascular Imaging ◽

10.1007/s10554-013-0253-3 ◽

2013 ◽

Vol 29 (S1) ◽

pp. 7-20 ◽

Cited By ~ 9

Author(s):

Masahiro Jinzaki ◽

Masaharu Hirano ◽

Kazuhiro Hara ◽

Takahiko Suzuki ◽

Akira Yamashina ◽

...

Keyword(s):

Phase Ii ◽

Cardiac Disease ◽

Dose Finding ◽

Double Blind ◽

Double Blind Placebo ◽

Short Acting ◽

Landiolol Hydrochloride ◽

Finding Study ◽

Dose Finding Study

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PD3-3-2: A randomized double-blind Phase IIa dose-finding study of vandetanib in Japanese patients with NSCLC

Journal of Thoracic Oncology ◽

10.1097/01.jto.0000283412.15497.33 ◽

2007 ◽

Vol 2 (8) ◽

pp. S466-S467

Author(s):

Yuichiro Ohe ◽

Katsuyuki Kiura ◽

Kazuhiko Nakagawa ◽

Tetsu Shinkai ◽

Kenji Eguchi ◽

...

Keyword(s):

Japanese Patients ◽

Dose Finding ◽

Double Blind ◽

Finding Study ◽

Dose Finding Study

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Efficacy and safety of a 3-month dosing regimen of degarelix in Japanese patients with prostate cancer: a phase II maintenance-dose-finding study

Japanese Journal of Clinical Oncology ◽

10.1093/jjco/hyx011 ◽

2017 ◽

Vol 47 (5) ◽

pp. 438-446 ◽

Cited By ~ 2

Author(s):

Seiichiro Ozono ◽

Taiji Tsukamoto ◽

Seiji Naito ◽

Yasuo Ohashi ◽

Takeshi Ueda ◽

...

Keyword(s):

Prostate Cancer ◽

Phase Ii ◽

Maintenance Dose ◽

Japanese Patients ◽

Dose Finding ◽

Efficacy And Safety ◽

Dosing Regimen ◽

Finding Study ◽

Dose Finding Study

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