Relationship of Enhanced Liver Fibrosis Score with Pediatric Non-alcoholic Fatty Liver Disease Histology and Response to Vitamin E or Metformin

Background: Nowadays, generating shear waves and simulation of the liver tissue is done using point shear-wave elastographic (pSWE) techniques which uess acoustic radiation force impulse (ARFI). Objective: This study aimed to evaluate the correlation between pSWE and liver function tests (LFTs) to predict liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD). Materials and methods: It was a cross sectional study conducted in an Ultrasound Clinic in Suleymaniya city. The duration of the study was from 1st of November, 2018 to 30th of June, 2019 which conducted on 50 NAFLD patients. After confirming NAFLD diagnosis, the patients were referred to Ultrasound Clinic to go under pSWE test. Results: The data showed that the mean PSWE of NAFLD patient was 4.12±0.87 Kpa; and 18% of them had high PSWE (> 4.6). Elastography fibrosis score was distributed to F0 (82%), F1 (6%), F2 (8%) and F3 (4%). There was a significant association between high APRI and high Aspartate Aminotransferase/Alanine Aminotransferase(AST/ALT) ratio (p=0.04). There was also a highly significant association between elastography fibrosis score and APRI fibrosis score among NAFLD patients (p<0.001). Conclusion: This study showed that the pSWE is a valuable noninvasive diagnostic technique for predicting liver fibrosis among NAFLD patients and there is significant correlation between APRI and pSWE scores. Keywords: Non-alcoholic fatty liver disease, Point shears wave elastography, Liver fibrosis.

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P2-562: NON-ALCOHOLIC FATTY LIVER DISEASE, LIVER FIBROSIS SCORE AND COGNITIVE FUNCTION IN MIDDLE-AGED ADULTS: THE FRAMINGHAM STUDY

Alzheimer s & Dementia ◽

10.1016/j.jalz.2019.06.2971 ◽

2019 ◽

Vol 15 ◽

pp. P837-P838

Author(s):

Galit Weinstein ◽

Kendra Davis-Plourde ◽

Jayandra J. Himali ◽

Shira Zelber-Sagi ◽

Alexa S. Beiser ◽

...

Keyword(s):

Liver Disease ◽

Cognitive Function ◽

Liver Fibrosis ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Framingham Study ◽

Fibrosis Score ◽

Alcoholic Fatty Liver ◽

Middle Aged Adults ◽

Alcoholic Fatty Liver Disease

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Non‐alcoholic fatty liver disease, liver fibrosis score and cognitive function in middle‐aged adults: The Framingham Study

Liver International ◽

10.1111/liv.14161 ◽

2019 ◽

Vol 39 (9) ◽

pp. 1713-1721 ◽

Cited By ~ 11

Author(s):

Galit Weinstein ◽

Kendra Davis‐Plourde ◽

Jayandra J. Himali ◽

Shira Zelber‐Sagi ◽

Alexa S. Beiser ◽

...

Keyword(s):

Liver Disease ◽

Cognitive Function ◽

Liver Fibrosis ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Framingham Study ◽

Fibrosis Score ◽

Alcoholic Fatty Liver ◽

Middle Aged Adults ◽

Alcoholic Fatty Liver Disease

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Direct comparison of the specialised blood fibrosis tests FibroMeterV2G and Enhanced Liver Fibrosis score in patients with non-alcoholic fatty liver disease from tertiary care centres

Alimentary Pharmacology & Therapeutics ◽

10.1111/apt.15529 ◽

2019 ◽

Vol 50 (11-12) ◽

pp. 1214-1222 ◽

Cited By ~ 8

Author(s):

Maeva Guillaume ◽

Valerie Moal ◽

Cyrielle Delabaudiere ◽

Floraine Zuberbuhler ◽

Marie-Angèle Robic ◽

...

Keyword(s):

Liver Disease ◽

Liver Fibrosis ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Tertiary Care ◽

Fibrosis Score ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

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Correlation Between Point Shear Wave Elastography and Liver Function Tests as A Predictor of Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease

10.53350/pjmhs211561990 ◽

2021 ◽

Vol 15 (6) ◽

pp. 1990-1994

Author(s):

Shahla Mohammed Saeed Rasul ◽

Ali Khalaf Salim ◽

Hiwa Abubakr Hussein

Keyword(s):

Liver Disease ◽

Liver Fibrosis ◽

Fatty Liver ◽

Shear Wave ◽

Fatty Liver Disease ◽

Shear Wave Elastography ◽

Liver Function Tests ◽

Fibrosis Score ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

Aim: of this study is to correlate between point shear wave elastography(pSWE) and liver function tests (LFTs) to predict liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD). Materials and methods: this study is a cross sectional study conducted in Ultrasound Clinic in Suleymaniya city. The duration of the study was through the period from 1st of November, 2018 to 30th of June, 2019 on 50 NAFLD patients. After confirming NAFLD diagnosis, the patients were referred to Ultrasound Clinic to complete Point Shear Wave Elastography (PSWE). Results: showed a mean PSWE of NAFLD patient was 4.12±0.87 Kpa; 18% of them had high PSWE (> 4.6). Elastography fibrosis score was distributed to F0 (82%), F1 (6%), F2 (8%) and F3 (4%). The Aspartate Aminotransferase Platelet Ratio Index (APRI) fibrosis scores were distributed to F0 (48%), F1-3 (48%) and F4 (4%), There was a highly significant association between elastography fibrosis score and APRI fibrosis score of NAFLD patients (p<0.001), There was no significant association between elastography fibrosis score and Aspartate Aminotransferase/Alanine Aminotransferase (AST/ALT) values of NAFLD patients (p=0.5). Conclusion: this study showed that the point shear wave elastography is a valuable noninvasive diagnostic technique for predicting significant liver fibrosis among patients with non-alcoholic liver fatty diseases and there is significant correlation between APRI score and pSWE score. The current gold standard in the diagnosis and staging of liver fibrosis is liver biopsy. Point shear wave elastography is among the noninvasive procedures to assess liver fibrosis. Keywords: Non-alcoholic fatty liver disease, Point shears wave elastography, Liver fibrosis.

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S1182 A New Frontier of Non-Alcoholic Fatty Liver Disease (NAFLD) Fibrosis Estimation: Comparing APRI and NAFLD Fibrosis Score (NFS) to Assess Liver Fibrosis Levels in Patients With and Without Diabetes

The American Journal of Gastroenterology ◽

10.14309/01.ajg.0000706776.35223.f9 ◽

2020 ◽

Vol 115 (1) ◽

pp. S591-S592

Author(s):

Scott Berger ◽

Natalie Nguyen ◽

Allison N. Boden ◽

Javier Sanchez ◽

Ana L. Romero ◽

...

Keyword(s):

Liver Disease ◽

Liver Fibrosis ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Fibrosis Score ◽

Alcoholic Fatty Liver ◽

Nafld Fibrosis Score ◽

New Frontier ◽

Alcoholic Fatty Liver Disease

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Author response: Non‐alcoholic fatty liver disease, liver fibrosis score and cognitive function in middle‐aged adults: The Framingham study

Liver International ◽

10.1111/liv.14318 ◽

2019 ◽

Vol 40 (5) ◽

pp. 1240-1240

Author(s):

Galit Weinstein ◽

Kendra L. Davis‐Plourde ◽

Alexa S. Beiser ◽

Sudha Seshadri

Keyword(s):

Liver Disease ◽

Cognitive Function ◽

Liver Fibrosis ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Framingham Study ◽

Fibrosis Score ◽

Alcoholic Fatty Liver ◽

Middle Aged Adults ◽

Alcoholic Fatty Liver Disease

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Relationship of sarcopenia with steatohepatitis and advanced liver fibrosis in non-alcoholic fatty liver disease: a meta-analysis

BMC Gastroenterology ◽

10.1186/s12876-018-0776-0 ◽

2018 ◽

Vol 18 (1) ◽

Cited By ~ 25

Author(s):

Rui Yu ◽

Qiangwei Shi ◽

Lei Liu ◽

Lidong Chen

Keyword(s):

Liver Disease ◽

Liver Fibrosis ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Meta Analysis ◽

Alcoholic Fatty Liver ◽

Advanced Liver Fibrosis ◽

Relationship Of ◽

Alcoholic Fatty Liver Disease

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Factors Associated with Prognosis of Non-Alcoholic Fatty Liver Disease

Asian Journal of Research in Medical and Pharmaceutical Sciences ◽

10.9734/ajrimps/2021/v10i230158 ◽

2021 ◽

pp. 1-12

Author(s):

Muamar M. A. Shaheen ◽

Mohanad Saleh ◽

Deema Sider ◽

Reem Al Natsheh ◽

Raghad Dweik

Keyword(s):

Liver Disease ◽

Liver Fibrosis ◽

Fatty Liver ◽

Statin Therapy ◽

Significant Relationship ◽

Fatty Liver Disease ◽

Fibrosis Score ◽

Alcoholic Fatty Liver ◽

Factors Associated ◽

Alcoholic Fatty Liver Disease

Background: At the junction between obesity, metabolic syndrome and liver failure, lies Non-alcoholic fatty liver disease. Recent studies elaborated on role of metformin in patients with non-alcoholic fatty liver disease. This observation has not been studied at a global scale, neither it was investigated in different ethnical groups. Objectives: We aim at determining the risk factors associated with prognosis of non-alcoholic fatty liver disease among a cohort of patients in Southern West Bank, Palestine. Methods: A retrospective cohort study involving 300 NAFLD patients who visited the internal medicine department at Hebron Governmental Hospital from October 2017 till September 2018. Two hundred and three patients diagnosed with non-alcoholic fatty liver disease, were included in this study. Lab test results within the past 6 months, comorbidity and medication history were collected from patients` profiles. Data was analyzed using SPSS V20. Liver Fibrosis score was determined by using non-alcoholic fatty liver disease fibrosis score calculator. Results: Two hundred and three non-alcoholic fatty liver disease patients (58.6% females), 54.78 (±12.27) years old were included in the study. Almost 65.5% of these patients have BMI >30 Kg/m2. It was found that, 62.25% of the 58 diabetic patients in this study had liver fibrosis score > 0.676 comparing to non-alcoholic fatty liver disease patients who are non-diabetic. There was a significant relationship between diabetes and fibrosis score, α=0.000. There was also a significant relationship between hyperlipidemia and fibrosis score of non-alcoholic fatty liver disease patients, α=0.023. We found a significant relationship between fibrosis score and hypertension, α=0.000. In the same context, there was a significant relationship between NAFLD patients who were on statin therapy and those who were not using statin therapy, α= 0.015. Metformin was not associated with significant relationship between users and non-users non-alcoholic fatty liver disease subjects. Conclusion: Diabetes mellitus, hypertension, hyperlipidemia and statin use were associated with NAFLD prognosis.

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