Seizure Severity and Treatment Response in Newborn Infants with Seizures Attributed to Intracranial Hemorrhage

2021 ◽  
Author(s):  
Emily M. Herzberg ◽  
Michelle Machie ◽  
Hannah C. Glass ◽  
Renée A. Shellhaas ◽  
Courtney J. Wusthoff ◽  
...  
Keyword(s):  
Treatment Response ◽  
Intracranial Hemorrhage ◽  
Newborn Infants ◽  
Seizure Severity

Intracranial hemorrhage in newborn infants

1983 ◽  
Vol 50 (4) ◽  
pp. 353-362 ◽  
Author(s):  
Seetha Shankaran
Keyword(s):  
Intracranial Hemorrhage ◽  
Newborn Infants

Timing and Antecedents of Intracranial Hemorrhage in the Newborn

PEDIATRICS ◽  
1984 ◽  
Vol 74 (1) ◽  
pp. 32-36
Author(s):  
Marilyn M. McDonald ◽  
Beverly L. Koops ◽  
Michael L. Johnson ◽  
Mary Anne Guggenheim ◽  
Carol M. Rumack ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Intracranial Hemorrhage ◽  
Intraventricular Hemorrhage ◽  
Pressure Fluctuations ◽  
Newborn Infants ◽  
Clinical Factors ◽  
Optimal Care ◽  
Apgar Scores ◽  
Temporal Relationships ◽  
Intrapartum Hemorrhage

Fifty newborn infants of less than 33 weeks' gestation were followed prospectively from birth to evaluate the temporal relationships of various clinical factors to the onset and progression of intracranial hemorrhage (ICH) in an inborn population given maximal support. ICH was diagnosed and followed with bedside ultrasound every eight hours. The incidence of intraventricular hemorrhage was 30% and of any ICH was 40% with onset from less than 2 hours to 8 days of age. Grades 2, 3, and 4 ICH correlated with Apgar scores of less than 5 at five minutes, vaginal delivery, longer labors, and intrapartum hemorrhage. There was a significant correlation between ICH and both blood pressure fluctuations of greater than 100% and rapid colloid infusions. Slow transfusions of packed red cells did not appear to precipitate episodes of ICH. In a setting of optimal care, ICH appears to be more related to prenatal stresses than to specific postnatal complications.

Hypoglycorrachia associated with intracranial hemorrhage in newborn infants

1979 ◽  
Vol 94 (5) ◽  
pp. 800-803 ◽  
Author(s):  
R.M. Nelson ◽  
R.L. Bucciarelli ◽  
J.W. Nagel ◽  
E.F. Beale ◽  
D.V. Eitzman
Keyword(s):  
Intracranial Hemorrhage ◽  
Newborn Infants

Quantitative Noninvasive Method to Measure Cerebral Blood Flow in Newborn Infants

PEDIATRICS ◽  
1979 ◽  
Vol 64 (3) ◽  
pp. 277-282
Author(s):  
Fergus A. N. Leahy ◽  
Koravangattu Sankaran ◽  
Don Cates ◽  
Marilyn MacCallum ◽  
Henrique Rigatto
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Intracranial Hemorrhage ◽  
Newborn Infants ◽  
Venous Occlusion ◽  
Gas Mixtures ◽  
Venous Occlusion Plethysmography ◽  
Noninvasive Method ◽  
Older Children

We measured cerebral blood flow (CBF) in 32 healthy neonates by venous occlusion plethysmography. Mean CBF was 63 ml/min/100 gm which compared favorably with invasive methods used in older children and adult subjects. We suggest that this is a useful method to quantify CBF in neonates. It may be valuable in assessing sequential changes occurring during asphyxia, intracranial hemorrhage, or during administration of various gas mixtures and drugs such as theophylline.

Role of Coagulopathy in Newborn Intracranial Hemorrhage

PEDIATRICS ◽  
1984 ◽  
Vol 74 (1) ◽  
pp. 26-31
Author(s):  
Marilyn M. McDonald ◽  
Michael L. Johnson ◽  
Carol M. Rumack ◽  
Beverly L. Koops ◽  
Mary Anne Guggenheim ◽  
...  
Keyword(s):  
Intracranial Hemorrhage ◽  
Blood Clotting ◽  
Antithrombin Iii ◽  
Newborn Infants ◽  
Premature Rupture Of Membranes ◽  
Intracranial Hemorrhages ◽  
Premature Rupture ◽  
Ultrasound Studies ◽  
Subsequent Onset

Fifty newborn infants of less than 33 weeks' gestation were followed prospectively from birth with serial coagulation and real-time ultrasound studies. A significant association of hypocoagulability in the first four hours of life with subsequent onset or progression of intraventricular or other clinical hemorrhages was documented. Abnormalities included lower values for fibrinogen, platelet count, antithrombin III, and factor VIII with higher values for fibrin monomer and longer Laidlaw whole blood clotting times. These abnormalities tended to correct spontaneously in surviving infants. An association between gestational complications and incidence of hypocoagulability and intracranial hemorrhage (ICH) was noted. Babies of preeclamptic mothers had fewer abnormalities and babies born to mothers with premature rupture of membranes and suspected amnionitis manifested more hypocoagulability and more severe intracranial hemorrhages.

Early Increase in Intracranial Pressure in Preterm Infants

PEDIATRICS ◽  
1978 ◽  
Vol 61 (6) ◽  
pp. 904-907
Author(s):  
Steven M. Donn ◽  
Alistair G. S. Philip
Keyword(s):  
Intracranial Pressure ◽  
Preterm Infants ◽  
Intracranial Hemorrhage ◽  
Newborn Infants ◽  
Noninvasive Measurement ◽  
Anterior Fontanel ◽  
Increased Intracranial Pressure ◽  
Early Increase

Noninvasive measurement of intracranial pressure is now available via the anterior fontanel in newborn infants. We measured intracranial pressure during the first week of life in 18 preterm infants and found a statistically significant increase from birth to age 24 hours and a significant decrease by 48 hours (13.8 vs. 24.4 vs. 14.3 cm H20). This did not seem to be the result of postnatal head shrinkage. There were no other apparent correlations. We suspect that hypoxia may play an important role in the etiology of increased intracranial pressure. We believe that these findings may have important implications for intracranial hemorrhage in preterm infants.

scholarly journals Coagulation studies in newborn infants with intracranial hemorrhage.

1987 ◽  
Vol 18 (1) ◽  
pp. 89-92
Author(s):  
Akira SHIRAHATA ◽  
Toshio NAKAMURA ◽  
Yoshikazu MIYAJI ◽  
Kaneo YAMADA
Keyword(s):  
Intracranial Hemorrhage ◽  
Newborn Infants

Bedside Ultrasound-Guided Percutaneous Needle Aspiration of Intra- and Extra-Axial Intracranial Hemorrhage in Neonates

2018 ◽  
Vol 49 (04) ◽  
pp. 238-245 ◽  
Author(s):  
Mehmet Cizmeci ◽  
Liesbeth Thewissen ◽  
Alexandra Zecic ◽  
Peter Woerdeman ◽  
Bart Boer ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Intracranial Hemorrhage ◽  
Motor Coordination ◽  
Newborn Infants ◽  
Needle Aspiration ◽  
Cranial Ultrasound ◽  
Midline Shift ◽  
Ultrasound Guided ◽  
Bedside Method

AbstractIntracranial hemorrhage is an important cause of brain injury in the neonatal population and bedside percutaneous needle aspiration has emerged as an alternative due to the major risks that can be caused by standard neurosurgical decompression. We aimed to assess the effectiveness of this minimally invasive bedside technique and conducted a retrospective analysis of all newborn infants with a large extra-axial hemorrhage associated with a parenchymal hemorrhage causing a midline shift, managed at three academic centers over a 15-year period. Collected data included clinical history, laboratory results, review of all imaging studies performed, and neurodevelopmental follow-up. Eight infants (3 preterm and 5 full-term) presented on day 1 to 2 with seizures (n = 6) and apneas (n = 5), signs of increased intracranial pressure (n = 4), and coning (n = 1). Risk factors were present in six. Cranial ultrasound and computed tomography showed a midline shift in all; two infants showed status epilepticus on amplitude-integrated electroencephalography with complete resolution after the procedure. Between 7 and 34 mL could be aspirated associated with a decrease in the midline shift as seen by ultrasonography performed during the puncture. No complications were seen related to the procedure and none of the infants required further acute neurosurgical intervention. On follow-up, three had mild sequelae, including motor coordination problems (n = 1) and hemianopia (n = 2); none developed cerebral palsy or postneonatal epilepsy. Neonates, presenting with severe symptoms, can be managed successfully using ultrasound-guided needle aspiration and this minimally invasive bedside method should be kept in mind before performing neurosurgical decompression.

scholarly journals Th17 cell-mediated immune response in a subpopulation of dogs with idiopathic epilepsy

PLoS ONE ◽  
2022 ◽  
Vol 17 (1) ◽  
pp. e0262285
Author(s):  
Anna Knebel ◽  
Annika Kämpe ◽  
Regina Carlson ◽  
Karl Rohn ◽  
Andrea Tipold
Keyword(s):  
Immune Response ◽  
Status Epilepticus ◽  
Treatment Response ◽  
Th17 Cell ◽  
Th17 Cells ◽  
Idiopathic Epilepsy ◽  
Serum Samples ◽  
Seizure Severity ◽  
Cell Mediated Immune Response ◽  
Cluster Seizures

Background Canine idiopathic epilepsy (IE) is a common neurological disease with severe impact on the owner´s and the dog’s quality of life. A subpopulation of dogs with IE does not respond to antiseizure drugs (non-responder). Th17 cells (T helper cells) and their proinflammatory Interleukin-17 (IL-17) are part of the immune system and previous studies showed their involvement in the pathogenesis of several autoimmune diseases. Non-responder might have an abnormal immune response against structures of the central nervous system. To discover a new aetiology of canine IE and thereby optimising the therapy of intractable IE, this prospective study aimed to investigate Th17 cells and IL-17 in dogs with IE. The underlying hypothesis was that in some dogs with IE a Th17 cell-mediated immune response could be detectable. Methods 57 dogs with IE and 10 healthy dogs (control group, C) were enrolled in the study. EDTA blood was taken to measure Th17 cells by flow cytometry. IL-17 was measured in 35 cerebrospinal fluid (CSF) and 33 serum samples using an enzyme-linked immunosorbent assay (ELISA). It was investigated whether there was a significant increase of stimulated Th17 cells in blood samples or of IL-17 in serum and CSF samples of dogs with IE in comparison to C. Correlations between the amount of Th17 cells/μL or IL-17 and different clinical parameters e.g. seizure frequency, seizure type, seizure severity or treatment response were evaluated. Additionally, Th17 cells/μL were randomly controlled of 17 dogs with IE and were examined for changes over time and in relation to treatment response. Results Ten dogs with IE had strongly elevated stimulated Th17 cells/μL within the blood (>100 Th17 cells/μL). A slight positive correlation between stimulated Th17 cells/μL and seizure severity (p = 0.046; rSpear = 0.27) was proven in these dogs. In addition, 4/10 dogs with elevated Th17 levels experienced cluster seizures and status epilepticus in comparison to 9% of the dogs with non-elevated Th17 levels (<100 Th17 cells/μL). Dogs with IE had significantly higher IL-17 values in CSF and serum samples compared to C (p<0.001; p<0.002; respectively). Conclusion In single dogs with IE, strongly increased amounts of Th17 cells were detectable and dogs with elevated Th17 cells seemed to have a greater risk for experiencing a combination of cluster seizures and status epilepticus. Therefore, an underlying Th17-cell mediated immune response was suspected and hence anti-inflammatory drugs could be indicated in these single cases with intractable epilepsy.

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