Low level laser therapy against radiation induced oral mucositis in elderly head and neck cancer patients-a randomized placebo controlled trial

2015 ◽  
Vol 144 ◽  
pp. 51-56 ◽  
Author(s):  
Ajay Prashad Gautam ◽  
Donald J. Fernandes ◽  
Mamidipudi S. Vidyasagar ◽  
Arun G. Maiya ◽  
Vausudev Guddattu
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Laser Therapy ◽  
Neck Cancer ◽  
Oral Mucositis ◽  
Controlled Trial ◽  
Low Level Laser Therapy ◽  
Level Laser ◽  
Radiation Induced

Effect of low-level laser therapy on chemoradiotherapy-induced oral mucositis and salivary inflammatory mediators in head and neck cancer patients

2015 ◽  
Vol 47 (4) ◽  
pp. 296-305 ◽  
Author(s):  
Angélica F. Oton-Leite ◽  
Geisa Badauy L. Silva ◽  
Marília O. Morais ◽  
Tarcília A. Silva ◽  
Cláudio R. Leles ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Laser Therapy ◽  
Neck Cancer ◽  
Oral Mucositis ◽  
Inflammatory Mediators ◽  
Low Level Laser Therapy ◽  
Low Level Laser ◽  
Level Laser

Phase III trial of low-level laser therapy to prevent oral mucositis in head and neck cancer patients treated with concurrent chemoradiation

2013 ◽  
Vol 109 (2) ◽  
pp. 297-302 ◽  
Author(s):  
Heliton S. Antunes ◽  
Daniel Herchenhorn ◽  
Isabele A. Small ◽  
Carlos M.M. Araújo ◽  
Celia Maria Pais Viégas ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Laser Therapy ◽  
Neck Cancer ◽  
Oral Mucositis ◽  
Phase Iii ◽  
Low Level Laser Therapy ◽  
Phase Iii Trial ◽  
Level Laser

Radiotherapy mucositis in head and neck cancer: prevention by low-energy surface laser

2019 ◽  
pp. bmjspcare-2019-001851
Author(s):  
Vincent Bourbonne ◽  
Joelle Otz ◽  
René-Jean Bensadoun ◽  
Gurvan Dissaux ◽  
Francois Lucia ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Laser Therapy ◽  
Oral Mucosa ◽  
Neck Cancer ◽  
Low Energy ◽  
Low Level Laser Therapy ◽  
Low Level Laser ◽  
Level Laser ◽  
Radiation Induced

BackgroundModern radiotherapy (RT) planning techniques and the use of oral supportive care have reduced the occurrence of acute radiation-induced toxicities. Oral mucositis remains a major concern in patients with head and neck cancer as it can compromise treatment compliance and outcome.ObjectiveTo report the rate of mucositis with the preventive use of surface low-level laser therapy in patients with head and neck cancer.MethodsForty patients treated with definitive (n=27) or adjuvant (n=13) RT using volumetric arc therapy between August 2014 and October 2015 for squamous cell carcinoma of the head and neck were included. All patients were treated using photobiomodulation using surface low-level laser therapy (Heltschl kind FL 3500, 350 mW), 3 times a week during the whole treatment course. The grade of mucositis was obtained from week 1 to week 7 and at 1 month.ResultsThe median RT dose was 70 Gy (64–70). Concomitant chemotherapy was administered in 29 patients. According to the Common Terminology Criteria for Adverse Events (CTCAE) v. 3, grade 0, 1, 2 and 3 mucositis was observed in 9 (22.5%), 9 (22.5%), 16 (40%) and 6 (15%) patients at week 7, and 32 (80%), 2 (5%), 3 (7.5%) and 3 (7.5%) patients at 1 month following treatment. No grade 4 occurred. Median average and maximum dose to the oral mucosa was 42 Gy (12.9–66.3) and 66.6 Gy (39–76), respectively.ConclusionDespite a substantial dose to the oral mucosa, the rate of acute radiation-induced mucositis of grade ≥3 remains low in patients receiving extraoral low-energy laser during RT.

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