Development of photo-magnetic drug delivery system by facile-designed dual stimuli-responsive modified biopolymeric chitosan capped nano-vesicle to improve efficiency in the anesthetic effect and its biological investigations

2020 ◽  
Vol 202 ◽  
pp. 111716 ◽  
Author(s):  
Hongwei Liu ◽  
Junfeng Liu ◽  
Xianfeng Xie ◽  
Xuebin Li
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Stimuli Responsive ◽  
Improve Efficiency ◽  
Anesthetic Effect ◽  
Magnetic Drug Delivery

Schiff base-containing dextran nanogel as pH-sensitive drug delivery system of doxorubicin: Synthesis and characterization

2018 ◽  
Vol 33 (2) ◽  
pp. 170-181 ◽  
Author(s):  
Hongying Su ◽  
Wen Zhang ◽  
Yayun Wu ◽  
Xiaodong Han ◽  
Gang Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Schiff Base ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Sensitive ◽  
Cell Uptake ◽  
Stimuli Responsive ◽  
Drug Release Profile

Stimuli-responsive hydrogels have been widely researched as carrier systems, due to their excellent biocompatibility and responsiveness to external physiologic environment factors. In this study, dextran-based nanogel with covalently conjugated doxorubicin (DOX) was developed via Schiff base formation using the inverse microemulsion technique. Since the Schiff base linkages are acid-sensitive, drug release profile of the DOX-loaded nanogel would be pH-dependent. In vitro drug release studies confirmed that DOX was released much faster under acidic condition (pH 2.0, 5.0) than that at pH 7.4. Approximately 66, 28, and 9% of drug was released in 72 h at pH 2.0, 5.0, and 7.4, respectively. Cell uptake by the human breast cancer cell (MCF-7) demonstrated that the DOX-loaded dextran nanogel could be internalized through endocytosis and distributed in endocytic compartments inside tumor cells. These results indicated that the Schiff base-containing nanogel can serve as a pH-sensitive drug delivery system. And the presence of multiple aldehyde groups on the nanogel are available for further conjugations of targeting ligands or imaging probes.

Impact of surface coated magnetite used in magnetic drug delivery system on immune response

2015 ◽  
Vol 117 (17) ◽  
pp. 17D135
Author(s):  
Yoshihiro Oaku ◽  
Junya Tamada ◽  
Fumihito Mishima ◽  
Yoko Akiyama ◽  
Mariana Kiomy Osako ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Immune Response ◽  
Drug Delivery System ◽  
Delivery System ◽  
Magnetic Drug Delivery

Preparation of keratin/chlorhexidine complex nanoparticles for long-term and dual stimuli-responsive release

RSC Advances ◽  
2015 ◽  
Vol 5 (100) ◽  
pp. 82334-82341 ◽  
Author(s):  
Xuelian Zhi ◽  
Yanfang Wang ◽  
Pengfei Li ◽  
Jiang Yuan ◽  
Jian Shen
Keyword(s):  
Drug Delivery ◽  
Complex Formation ◽  
Drug Delivery System ◽  
Delivery System ◽  
Convenient Method ◽  
Stimuli Responsive ◽  
Polyion Complex

Nanoscale polyion complex formation via the electrostatic complexation of a polyelectrolyte and a charged drug is the most convenient method for building a drug delivery system that simultaneously realizes the carrier preparation and drug embedding.

Evaluation of superabsorbent linseed-polysaccharides as a novel stimuli-responsive oral sustained release drug delivery system

2016 ◽  
Vol 43 (3) ◽  
pp. 409-420 ◽  
Author(s):  
Muhammad Tahir Haseeb ◽  
Muhammad Ajaz Hussain ◽  
Sajid Bashir ◽  
Muhammad Umer Ashraf ◽  
Naveed Ahmad
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Stimuli Responsive ◽  
Release Drug
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