Preparation of keratin/chlorhexidine complex nanoparticles for long-term and dual stimuli-responsive release

RSC Advances ◽  
2015 ◽  
Vol 5 (100) ◽  
pp. 82334-82341 ◽  
Author(s):  
Xuelian Zhi ◽  
Yanfang Wang ◽  
Pengfei Li ◽  
Jiang Yuan ◽  
Jian Shen
Keyword(s):  
Drug Delivery ◽  
Complex Formation ◽  
Drug Delivery System ◽  
Delivery System ◽  
Convenient Method ◽  
Stimuli Responsive ◽  
Polyion Complex

Nanoscale polyion complex formation via the electrostatic complexation of a polyelectrolyte and a charged drug is the most convenient method for building a drug delivery system that simultaneously realizes the carrier preparation and drug embedding.

Schiff base-containing dextran nanogel as pH-sensitive drug delivery system of doxorubicin: Synthesis and characterization

2018 ◽  
Vol 33 (2) ◽  
pp. 170-181 ◽  
Author(s):  
Hongying Su ◽  
Wen Zhang ◽  
Yayun Wu ◽  
Xiaodong Han ◽  
Gang Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Schiff Base ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Sensitive ◽  
Cell Uptake ◽  
Stimuli Responsive ◽  
Drug Release Profile

Stimuli-responsive hydrogels have been widely researched as carrier systems, due to their excellent biocompatibility and responsiveness to external physiologic environment factors. In this study, dextran-based nanogel with covalently conjugated doxorubicin (DOX) was developed via Schiff base formation using the inverse microemulsion technique. Since the Schiff base linkages are acid-sensitive, drug release profile of the DOX-loaded nanogel would be pH-dependent. In vitro drug release studies confirmed that DOX was released much faster under acidic condition (pH 2.0, 5.0) than that at pH 7.4. Approximately 66, 28, and 9% of drug was released in 72 h at pH 2.0, 5.0, and 7.4, respectively. Cell uptake by the human breast cancer cell (MCF-7) demonstrated that the DOX-loaded dextran nanogel could be internalized through endocytosis and distributed in endocytic compartments inside tumor cells. These results indicated that the Schiff base-containing nanogel can serve as a pH-sensitive drug delivery system. And the presence of multiple aldehyde groups on the nanogel are available for further conjugations of targeting ligands or imaging probes.

Development of biodegradable polyesters based on a hydroxylated coumarin initiator towards fluorescent visible paclitaxel-loaded microspheres

2019 ◽  
Vol 7 (14) ◽  
pp. 2261-2276 ◽  
Author(s):  
Yufei Bian ◽  
Zhiyong Wei ◽  
Zefeng Wang ◽  
Zhu Tu ◽  
Liuchun Zheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Physical Properties ◽  
Drug Delivery System ◽  
Delivery System ◽  
Controlled Drug Release ◽  
Biodegradable Polyesters ◽  
Biomedical Field

A facile method of end-functionalization was used to synthesize a series of fluorescent biodegradable polyesters with tailorable physical properties, which can promisingly be applied in the biomedical field as a controllable and traceable drug delivery system, especially for long-term controlled drug release.

Evaluation of superabsorbent linseed-polysaccharides as a novel stimuli-responsive oral sustained release drug delivery system

2016 ◽  
Vol 43 (3) ◽  
pp. 409-420 ◽  
Author(s):  
Muhammad Tahir Haseeb ◽  
Muhammad Ajaz Hussain ◽  
Sajid Bashir ◽  
Muhammad Umer Ashraf ◽  
Naveed Ahmad
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Stimuli Responsive ◽  
Release Drug

scholarly journals Tumor Microenvironment-Stimuli Responsive Nanoparticles for Anticancer Therapy

2020 ◽  
Vol 7 ◽  
Author(s):  
Reju George Thomas ◽  
Suchithra Poilil Surendran ◽  
Yong Yeon Jeong
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
The Body ◽  
Stimuli Responsive ◽  
Redox Enzyme ◽  
Nano Drug Delivery ◽  
Different Types ◽  
Internal Ph ◽  
Stimuli Response

Cancer is a disease that affects a large number of people all over the world. For treating cancer, nano-drug delivery system has been introduced recently with objective of increasing therapeutic efficiency of chemotherapeutic drug. The main characteristics of this system are the encapsulation of the insoluble chemotherapeutic cargo, increasing the period of circulation in the body, as well as the delivery of the drug at that specific site. Currently, the nano-drug delivery system based on the stimuli response is becoming more popular because of the extra features for controlling the drug release based on the internal atmosphere of cancer. This review provides a summary of different types of internal (pH, redox, enzyme, ROS, hypoxia) stimuli-responsive nanoparticle drug delivery systems as well as perspective for upcoming times.

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