Effects of haloperidol and risperidone on psychomotor performance relevant to driving ability in schizophrenic patients compared to healthy controls

2005 ◽  
Vol 39 (1) ◽  
pp. 101-108 ◽  
Author(s):  
Michael Soyka ◽  
Catja Winter ◽  
Sabine Kagerer ◽  
Manfred Brunnauer ◽  
Gerd Laux ◽  
...  
2001 ◽  
Vol 12 (1) ◽  
pp. 49-53 ◽  
Author(s):  
Michael Soyka ◽  
Sebastian Dittert ◽  
Martin Schäfer ◽  
Andreas Gartenmaier ◽  
Gerd Laux ◽  
...  

Abstract: Cognitive dysfunction has been recognized as an important clinical feature of schizophrenia. The possible pharmacological effect of neuroleptics on cognitive and psychomotor function including driving ability is crucial for rehabilitation of schizophrenic patients. Atypical neuroleptics such as risperidone have been shown to improve cognitive deficits in schizophrenics. We conducted a naturalistic nonrandomized clinical study to determine the effect of risperidone on psychomotor function compared to haloperidol in schizophrenic patients. In this study the psychomotor performance of 26 patients, who met the ICD-10 and DSM-IV criteria for schizophrenia, was assessed by means of ART-90, a computer-based Act & React Testsystem. 11 patients were on risperidone (mean dosage 4.0 mg) and 15 patients on haloperidol (mean dosage 10.5 mg). Patients were examined at discharge after psychopathological stabilization. In some relevant items the patients in the haloperidol group showed more impaired performance compared to the patients in the risperidone group. These preliminary data indicate a possible beneficial effect of risperidone compared to haloperidol on psychomotor performance and driving ability. Further randomized trials are necessary.


2003 ◽  
Vol 47 (4) ◽  
pp. 212-218 ◽  
Author(s):  
Sabine Kagerer ◽  
Catja Winter ◽  
Hans-Jürgen Möller ◽  
Michael Soyka

2014 ◽  
Vol 24 (6) ◽  
pp. 283-284
Author(s):  
Afke F. Terwisscha van Scheltinga ◽  
Steven C. Bakker ◽  
Neeltje E.M. van Haren ◽  
Heleen B.M. Boos ◽  
Hugo G. Schnack ◽  
...  

2014 ◽  
Vol 17 ◽  
Author(s):  
Tânia Silva ◽  
Luís Monteiro ◽  
Emanuela Lopes

AbstractAlthough several brief sensitive screening tools are available to detect executive dysfunction, few have been developed to quickly assess executive functioning. The INECO Frontal Screening (IFS) is a brief tool which has proved be useful for the assessment of the executive functions in patients with dementia. The aim of this study was to explore whether the IFS is as sensitive and specific as the BADS, a battery designed to assess the dysexecutive syndrome, in schizophrenia. Our sample comprised a group of 34 schizophrenic patients (Mean age = 39.59, DP = 10.697) and 31 healthy controls (Mean age = 35.52, DP = 10.211). To all groups were administered the BADS, Wisconsin Card Sorting Test and IFS. The results suggest that schizophrenic patients performed significantly worse than the control group in all tests (p < .05). The IFS total score was 13.29 for the experimental group and 26.21 for the control group (p < .001). Considering a cut-off of 14 points, the IFS sensitivity was 100% and specificity 56% in detection of executive dysfunction in schizophrenia, compared with the BADS, that if we consider a cut-off of 11 points, was a sensitivity of 100% and a specificity of 50%. Thus, IFS is a brief, sensitive and specific tool for the detection of executive dysfunction in schizophrenia.


2000 ◽  
Vol 41 (1) ◽  
pp. 283-284
Author(s):  
A. Rossi ◽  
P. Stratta ◽  
M. Grazia Marinangeli ◽  
E. Daneluzzo ◽  
M. Bustini ◽  
...  

1997 ◽  
Vol 171 (1) ◽  
pp. 31-34 ◽  
Author(s):  
Taha Karaman ◽  
Sibel Özkaynak ◽  
Korkut Yaltkaya ◽  
Çetin Büyükberker

BackgroundSeveral reports have documented the presence of motor abnormalities in schizophrenic patients.MethodThirty schizophrenics and 28 healthy controls were included in the study. Scalp-recorded bereitschaftpotentials (BPs) generated prior to voluntary movements were recorded in all subjects.ResultsThe early (NSI) and late components of BP and peak negativity were reduced in all schizophrenic patients. In particular, the NSI was reduced in patients with positive symptoms, and the late component in patients with negative symptoms.ConclusionsThese findings provide further support for the involvement of frontal cortex, subcortical structures and their connections in schizophrenia, and highlight some differences between positive and negative symptom clusters.


1998 ◽  
Vol 31 (06) ◽  
pp. 232-235 ◽  
Author(s):  
M. Soyka ◽  
C. Aichmüller ◽  
U. Preuss ◽  
H.-J. Möller

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