Abnormalities in the structural covariance of emotion regulation networks in major depressive disorder

BackgroundDepressed patients show impaired performance following negative feedback; the probability of committing an error is increased immediately after an error. This deficit is assumed to be highly specific and to represent a trait marker of major depressive disorder (MDD). Inconsistencies in currently available data could reflect inter-individually different strategies to regulate negative affect. The present study examined modulation of performance following negative feedback by cognitive reappraisal to regulate aversive affect in depressed patients.MethodThirty-three depressed patients and 33 control subjects performed tasks of varying difficulty over a prolonged time. Emotional feedback was given immediately after each trial. Performance was further analysed within subgroups using cognitive reappraisal of aversive events with high and low frequency.ResultsA significant group by task difficulty interaction for absolute number of subsequent errors revealed that depressed patients were especially impaired when receiving negative feedback more frequently. An increased probability of subsequent errors was shown in patients irrespective of task difficulty. Analysis of subgroups revealed higher absolute number and probability of subsequent errors only in depressed patients habitually not using cognitive reappraisal to regulate aversive emotions. Depressed patients using this strategy did not differ from controls.ConclusionsThe present results replicate the observation of impaired performance in depressed patients following failure feedback. Most importantly, a subgroup of patients who habitually rely on cognitive reappraisal of aversion-eliciting events, such as negative performance feedback, was not impaired. This modulatory influence of emotion regulation strategies on performance subsequent to negative feedback suggests that training emotion regulation in achievement situations should be incorporated in current concepts to prevent relapse.

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P.183 A neuroimaging study of functional connectivity during an emotion regulation task in major depressive disorder and borderline personality disorder

European Neuropsychopharmacology ◽

10.1016/j.euroneuro.2019.09.227 ◽

2019 ◽

Vol 29 ◽

pp. S140

Author(s):

V. De La Peña Arteaga ◽

T. Steward ◽

M. Berruga-Sánchez ◽

X. Goldberg ◽

I. Martínez-Zalacaín ◽

...

Keyword(s):

Major Depressive Disorder ◽

Emotion Regulation ◽

Borderline Personality Disorder ◽

Functional Connectivity ◽

Personality Disorder ◽

Depressive Disorder ◽

Borderline Personality ◽

Major Depressive ◽

Neuroimaging Study

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Neural correlates of dysfunctional emotion regulation in major depressive disorder. A systematic review of neuroimaging studies

Neuroscience & Biobehavioral Reviews ◽

10.1016/j.neubiorev.2013.07.018 ◽

2013 ◽

Vol 37 (10) ◽

pp. 2529-2553 ◽

Cited By ~ 230

Author(s):

Maria M. Rive ◽

Geeske van Rooijen ◽

Dick J. Veltman ◽

Mary L. .Phillips ◽

Aart H. Schene ◽

...

Keyword(s):

Systematic Review ◽

Major Depressive Disorder ◽

Emotion Regulation ◽

Depressive Disorder ◽

Neural Correlates ◽

Major Depressive

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A pilot investigation of emotional regulation difficulties and mindfulness-based strategies in manic and remitted bipolar I disorder and major depressive disorder

International Journal of Bipolar Disorders ◽

10.1186/s40345-020-00206-0 ◽

2021 ◽

Vol 9 (1) ◽

Author(s):

Christie W. Musket ◽

Natasha S. Hansen ◽

Keith M. Welker ◽

Kirsten E. Gilbert ◽

June Gruber

Keyword(s):

Major Depressive Disorder ◽

Emotion Regulation ◽

Depressive Disorder ◽

Emotional Regulation ◽

Preliminary Investigation ◽

Major Depressive ◽

Bipolar I Disorder ◽

Difficulties In Emotion Regulation ◽

Specific Emotion ◽

Pilot Investigation

Abstract Background Both bipolar disorder and major depressive disorder are characterized by difficulties in emotion regulation. Little is known about which specific emotion regulatory patterns may be transdiagnostic versus disorder specific, and how such patterns change as a function of current mood states. Methods This preliminary investigation examined specific patterns of self-reported trait emotion regulation difficulties and mindfulness-based regulations strategies across four groups: remitted adults with bipolar I disorder (BD-remitted; n = 32), currently manic adults with bipolar I disorder (BD-manic; n = 19), remitted adults with major depressive disorder (MDD-remitted; n = 32), and healthy controls (CTL; n = 30). Results All three clinical groups reported significantly greater difficulties with emotion regulation and decreased overall mindfulness-based strategies. Conclusions These results suggest that increased emotion regulation difficulties, decreased mindfulness, and increased emotion-driven impulsivity may be transdiagnostic across mood disorders and states, and that impulsivity may be particularly impaired during periods of mania.

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Functional connectivity changes with rapid remission from moderate-to-severe major depressive disorder

10.1101/672154 ◽

2019 ◽

Author(s):

Xiaoqian Xiao ◽

Brandon S. Bentzley ◽

Eleanor J. Cole ◽

Claudia Tischler ◽

Katy H. Stimpson ◽

...

Keyword(s):

Major Depressive Disorder ◽

Emotion Regulation ◽

Prefrontal Cortex ◽

Functional Connectivity ◽

Depressive Disorder ◽

Major Depressive ◽

Disease Heterogeneity ◽

Limited Effectiveness ◽

Brain Changes ◽

The Brain

AbstractMajor depressive disorder (MDD) is prevalent and debilitating, and development of improved treatments is limited by insufficient understanding of the neurological changes associated with disease remission. In turn, efforts to elucidate these changes have been challenging due to disease heterogeneity as well as limited effectiveness, delayed onset, and significant off-target effects of treatments. We developed a form of repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex (lDLPFC) that in an open-label study was associated with remission from MDD in 90% of individuals in 1-5 days (Stanford Accelerated Intelligent Neuromodulation Therapy, SAINT). This provides a tool to begin exploring the functional connectivity (FC) changes associated with MDD remission. Resting-state fMRI scans were performed before and after SAINT in 18 participants with moderate-to-severe, treatment-resistant MDD. FC was determined between regions of interest defined a priori by well-described roles in emotion regulation. Following SAINT, FC was significantly decreased between subgenual cingulate cortex (sgACC) and 3 of 4 default mode network (DMN) nodes. Significant reductions in FC were also observed between the following: DLPFC-striatum, DLPFC-amygdala, DMN-amygdala, DMN-striatum, and amygdala-striatum. Greater clinical improvements were correlated with larger decreases in FC between DLPFC-amygdala and DLPFC-insula, as well as smaller decreases in FC between sgACC-DMN. Greater clinical improvements were correlated with lower baseline FC between DMN-DLPFC, DMN-striatum, and DMN-ventrolateral prefrontal cortex. The multiple, significant reductions in FC we observed following SAINT and remission from depression support the hypothesis that MDD is a state of hyper-connectivity within these networks, and rapid decoupling of network nodes may lead to rapid remission from depression.Significance statementMajor depressive disorder is common and debilitating. It has been difficult to study the brain changes associated with recovery from depression, because treatments take weeks-to-months to become effective, and symptoms fail to resolve in many people. We recently developed a type of magnetic brain stimulation called SAINT. SAINT leads to full remission from depression in 90% of people within 5 days. We used SAINT and functional magnetic resonance imaging to determine how the brain changes with rapid remission from depression. We found changes in areas of the brain associated with emotion regulation. This provides a significantly clearer picture of how the non-depressed brain differs from the depressed brain, which can be used to develop rapid and effective treatments for depression.

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