Effects of chronic anabolic steroid treatment on tonic and reflex cardiovascular control in male rats

ABSTRACT With the aid of metenolon-17α-T a tritium-transfer to oestrone in rat liver slices was demonstrated. This tritium-transfer from metenolon17α-T to oestrone yielding tritium-labelled oestradiol had a higher efficiency in male than in female rat liver. Correspondingly in the presence of metenolon the relation of oestrone to oestradiol is changed more in male than in female rat liver. Looking for biochemical differences between the anabolic steroid metenolon and testosterone the oxydation at C17 was measured in different organs of the rat using 17α-T-labelled steroids. The highest oxydation rate was found for both steroids in the liver. In the sexual organs of male rats the oxydation rate of testosterone was 50–10 times higher than that of the anabolic steroid. This difference was less in sexual organs of female rats. This result of a greater biochemical difference between both steroids in males than in females leads to the question, whether the dissociation between the anabolic and the androgen effects is higher in males than in females.

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Anabolic steroid treatment increases myofiber damage in mdx mouse muscular dystrophy

Journal of the Neurological Sciences ◽

10.1016/0022-510x(94)90026-4 ◽

1994 ◽

Vol 125 (2) ◽

pp. 138-146 ◽

Cited By ~ 19

Author(s):

M.J. Krahn ◽

J.E. Anderson

Keyword(s):

Muscular Dystrophy ◽

Anabolic Steroid ◽

Steroid Treatment ◽

Mdx Mouse

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Treadmill Exercise Training Prevents Myocardial Mechanical Dysfunction Induced by Androgenic-Anabolic Steroid Treatment in Rats

PLoS ONE ◽

10.1371/journal.pone.0087106 ◽

2014 ◽

Vol 9 (2) ◽

pp. e87106 ◽

Cited By ~ 8

Author(s):

Danilo S. Bocalini ◽

Abram Beutel ◽

Cássia T. Bergamaschi ◽

Paulo J. Tucci ◽

Ruy R. Campos

Keyword(s):

Exercise Training ◽

Anabolic Steroid ◽

Treadmill Exercise ◽

Steroid Treatment ◽

Androgenic Anabolic Steroid

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Effect of anabolic steroid treatment on endurance

Medicine & Science in Sports & Exercise ◽

10.1249/00005768-197500740-00008 ◽

1975 ◽

Vol 7 (4) ◽

pp. 287???289 ◽

Cited By ~ 3

Author(s):

L. C. JOHNSON ◽

E. S. ROUNDY ◽

P. E. ALLSEN ◽

A. G. FISHER ◽

L. J. SILVESTER

Keyword(s):

Anabolic Steroid ◽

Steroid Treatment

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MUSCLE ELECTROMECHANICAL PROPERTIES FOLLOWING EXERCISE TRAINING AND ANABOLIC STEROID TREATMENT IN MALE AND FEMALE RATS

Medicine & Science in Sports & Exercise ◽

10.1249/00005768-198504000-00065 ◽

1985 ◽

Vol 17 (2) ◽

pp. 195

Author(s):

G. Kamen ◽

D. Bredle ◽

G. Brown ◽

J. Wilkerson

Keyword(s):

Exercise Training ◽

Anabolic Steroid ◽

Steroid Treatment ◽

Female Rats ◽

Electromechanical Properties ◽

Male And Female ◽

Male And Female Rats

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GONADOTROPHIN SUPPRESSION BY STEROIDS IN NORMAL, ADULT MALE RATS

Acta Endocrinologica ◽

10.1530/acta.0.0840842 ◽

1977 ◽

Vol 84 (4) ◽

pp. 842-849 ◽

Cited By ~ 2

Author(s):

H. L. Verjans ◽

K. B. Eik-Nes

Keyword(s):

Body Weight ◽

High Activity ◽

Adult Male ◽

Subcutaneous Administration ◽

Serum Levels ◽

Steroid Treatment ◽

Male Rats ◽

Normal Adult ◽

Serum Lh ◽

Testosterone Metabolites

ABSTRACT Effects of subcutaneous administration of various doses of different steroids on serum levels of LH and FSH in normal, adult male rats were investigated. Each steroid was injected daily during 7 days in doses of 50, 25, 12.5 or 6.25 μg per 100 g body weight. Ring A 5α-reduced testosterone metabolites exerted high activity in suppressing serum LH and FSH levels. 5α-Androstane-3β,17β-diol had in the doses tested, however, no such effects on serum gonadotrophins. Serum LH concentrations in normal rats appeared more sensitive to steroid treatment than serum FSH concentrations.

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