scholarly journals Normal-phase LC method for simultaneous analysis of pseudophedrine hydrochloride, dextromethorphan hydrobromide, chlorpheniramine maleate, and paracetamol in tablet formulations

2010 ◽  
Vol 18 (2) ◽  
pp. 103-106 ◽  
Author(s):  
Fuad Al-Rimawi
Keyword(s):  
Normal Phase ◽  
Simultaneous Analysis ◽  
Chlorpheniramine Maleate ◽  
Tablet Formulations ◽  
Dextromethorphan Hydrobromide

A Rapid Method for Simultaneous Analysis of Lignan and γ-Tocopherol in Sesame Oil by Using Normal-Phase Liquid Chromatography

2018 ◽  
Vol 95 (1) ◽  
pp. 13-19 ◽  
Author(s):  
Long-Kai Shi ◽  
Li Zheng ◽  
Yin-Feng Xiang ◽  
Rui-Jie Liu ◽  
Ming Chang ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
Rapid Method ◽  
Normal Phase ◽  
Sesame Oil ◽  
Simultaneous Analysis ◽  
Phase Liquid

scholarly journals Simultaneous Determination of Some Active Ingredients in Cough and Cold Preparations by Gas Chromatography, and Method Validation

2005 ◽  
Vol 88 (4) ◽  
pp. 1093-1098 ◽  
Author(s):  
Thresiana Harsono ◽  
Mochammad Yuwono ◽  
Gunawan Indrayanto
Keyword(s):  
Simultaneous Determination ◽  
Fused Silica ◽  
Chlorpheniramine Maleate ◽  
Column Temperature ◽  
Flame Ionization ◽  
Phenylpropanolamine Hydrochloride ◽  
Fused Silica Capillary ◽  
Silica Capillary Column ◽  
Dextromethorphan Hydrobromide

Abstract A simple and rapid gas chromatographic (GC) method has been developed for the simultaneous determination of combinations of acetaminophen, phenylpropanolamine hydrochloride, guaifenesin, pseudoephedrine hydrochloride, caffeine, chlorpheniramine maleate, and dextromethorphan hydrobromide in cough and cold tablets and syrups. After extraction of the analyte with alkaline ethyl acetate, 2 μL extract was injected (splitting ratio of 50:1) into a gas chromatograph equipped with a CBP1-M25-025 fused silica capillary column (25 m × 0.22 mm; film thickness, 0.25 μm). The column temperature was held at 150°C for 5 min, increased to 175°C at 3°C/min, and increased to 270°C at 10°C/min. The temperatures of the flame ionization detector and injector were maintained at 300°C. The GC method is inexpensive, rapid, accurate, and precise, and thus it can be used for routine analysis of tablet and syrup preparations in quality control laboratories of pharmaceutical companies.

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