Acetaminophen, Chlorpheniramine Maleate, and Dextromethorphan Hydrobromide Tablets

2021 ◽  
Keyword(s):  
Chlorpheniramine Maleate ◽  
Dextromethorphan Hydrobromide

scholarly journals Simultaneous Determination of Some Active Ingredients in Cough and Cold Preparations by Gas Chromatography, and Method Validation

2005 ◽  
Vol 88 (4) ◽  
pp. 1093-1098 ◽  
Author(s):  
Thresiana Harsono ◽  
Mochammad Yuwono ◽  
Gunawan Indrayanto
Keyword(s):  
Simultaneous Determination ◽  
Fused Silica ◽  
Chlorpheniramine Maleate ◽  
Column Temperature ◽  
Flame Ionization ◽  
Phenylpropanolamine Hydrochloride ◽  
Fused Silica Capillary ◽  
Silica Capillary Column ◽  
Dextromethorphan Hydrobromide

Abstract A simple and rapid gas chromatographic (GC) method has been developed for the simultaneous determination of combinations of acetaminophen, phenylpropanolamine hydrochloride, guaifenesin, pseudoephedrine hydrochloride, caffeine, chlorpheniramine maleate, and dextromethorphan hydrobromide in cough and cold tablets and syrups. After extraction of the analyte with alkaline ethyl acetate, 2 μL extract was injected (splitting ratio of 50:1) into a gas chromatograph equipped with a CBP1-M25-025 fused silica capillary column (25 m × 0.22 mm; film thickness, 0.25 μm). The column temperature was held at 150°C for 5 min, increased to 175°C at 3°C/min, and increased to 270°C at 10°C/min. The temperatures of the flame ionization detector and injector were maintained at 300°C. The GC method is inexpensive, rapid, accurate, and precise, and thus it can be used for routine analysis of tablet and syrup preparations in quality control laboratories of pharmaceutical companies.

scholarly journals Assessment of the greenness of micellar HPLC method for rapid separation and simultaneous estimation of chlorpheniramine maleate in presence of some co-administered drugs in three pharmaceutical dosage forms using single run

2021 ◽  
Author(s):  
Zeinab Adel Nasr ◽  
Marwa M. Soliman ◽  
Ekram H. Mohamed ◽  
Fatma A. Fouad
Keyword(s):  
Mobile Phase ◽  
Sodium Dodecyl ◽  
Dosage Forms ◽  
Hplc Method ◽  
Sustainable Chemistry ◽  
Simultaneous Estimation ◽  
Dihydrogen Phosphate ◽  
Chlorpheniramine Maleate ◽  
Pharmaceutical Dosage Forms ◽  
Dextromethorphan Hydrobromide

AbstractSustainable chemistry established one of kind standards to maintain protection of environment through using safer mobile phase composition and/or lower solvent consumption. A fast green micellar HPLC method was developed and applied for the first time aiming at simultaneous determination of chlorpheniramine maleate, one of the most widely used antihistamine in combination with levochlopersatine fenodizoate or dextromethorphan hydrobromide or dexamethasone, in their pure forms, laboratory prepared mixtures and pharmaceutical dosage forms used in alleviating the symptoms of cough resulting from common colds and allergy. The separation was achieved on Kinetex C18 column (100 mm × 4.6 mm i.d., 2.6-μm particle size) using micellar aqueous mobile phase consisting of (30 mM sodium dodecyl sulfate and 50 mM sodium dihydrogen phosphate, pH 5) and ethanol (85:15) with UV detection at 230 nm. The four drugs were successfully separated using isocratic elution in a single run not exceeding 7 min. According to ICH guidelines, the method was confirmed to be linear, accurate and precise over the concentration ranges of 5–60 μg mL−1 for chlorpheniramine maleate, 10–100 μg mL−1 for levocloperastine fenodizoate and dextromethorphan hydrobromide and 5–30 μg mL−1 for dexamethasone. In addition, the greenness of the developed method was assessed using two different tools indicating their least hazardous effect on the environment.

RP-UPLC Stability Indicating Assay Method for Simultaneous Estimation of Dextromethorphan Hydrobromide and Chlorpheniramine Maleate in Tablet Dosage Form

2020 ◽  
Vol 5 (3) ◽  
pp. 192-196
Author(s):  
A.J. Patel ◽  
N.K. Patel ◽  
A.J. Vyas ◽  
A.B. Patel ◽  
A.I. Patel
Keyword(s):  
Dosage Form ◽  
Assay Method ◽  
Simultaneous Estimation ◽  
Chlorpheniramine Maleate ◽  
Acquity Uplc ◽  
Tablet Dosage ◽  
Dextromethorphan Hydrobromide ◽  
Ich Guideline ◽  
Alkaline Oxidation

RP-UPLC method was developed and validated for the determination of chlorpheniramine maleate and dextromethorphan hydrobromide in tablet dosage form. Reverse phase waters acquity UPLC BEH C18 (50 mm × 2.1 mm, 1.7 μm) column using isocratic mobile phase of 0.5 mL 0.1% TFA (trifluroacetic acid) in H2O:CH3CN (70:30 %v/v). The flow rate was 0.2 mL/min and 252 nm wavelength use for detection on PDA detector. The retention time of chlorpheniramine maleate was 1.2 min and 2.2 min for dextromethorphan hydrobromide. Chlorpheniramine maleate and dextromethorphan hydrobromide was subjected to stress conditions including acidic, alkaline, oxidation, photolysis and thermal degradation. The method was validated as per ICH guideline with respect to samples to specificity, precision, accuracy, linearity and robustness.

Determination of the food azo dye carmoisine vs chlorpheniramine maleate ion associate structure

2014 ◽  
Vol 0 (3(79)) ◽  
pp. 34-37
Author(s):  
A. S. Materiienko ◽  
V. O. Grudko ◽  
V. A. Khanin ◽  
V. A. Georgiyants
Keyword(s):  
Azo Dye ◽  
Chlorpheniramine Maleate ◽  
Ion Associate
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