Doxycycline hyclate-loaded bleached shellac in situ forming microparticle for intraperiodontal pocket local delivery

2016 ◽  
Vol 93 ◽  
pp. 360-370 ◽  
Author(s):  
Thawatchai Phaechamud ◽  
Nuttapong Chanyaboonsub ◽  
Orn Setthajindalert
Keyword(s):  
Local Delivery ◽  
Doxycycline Hyclate ◽  
In Situ Forming ◽  
Bleached Shellac

Injectable in-situ Forming Depot Of Doxycycline Hyclate/α-Cyclodextrin Complex using PLGA for Periodontitis Treatment: Preparation, Charac-terization, and In-Vitro Evaluation

2020 ◽  
Vol 17 ◽  
Author(s):  
Elham Khodaverdi ◽  
Farhad Eisvand ◽  
Mohammad Sina Nezami ◽  
Seyedeh Nesa Rezaeian Shiadeh ◽  
Hossein Kamali ◽  
...  
Keyword(s):  
Complex Form ◽  
Docking Studies ◽  
Morphological Properties ◽  
Burst Release ◽  
Cyclodextrin Complex ◽  
Doxycycline Hyclate ◽  
Scanning Calorimetry ◽  
In Situ Forming

Background:: Doxycycline (DOX) is used in treating a bacterial infection, especially for periodontitis treatment. Objective: To reduce irritation of DOX for subgingival administration and increase the chemical stability and against enzy-matic, the complex of α-cyclodextrin with DOX was prepared and loaded into injectable in situ forming implant based on PLGA. Methods:: FTIR, molecular docking studies, X-ray diffraction, and differential scanning calorimetry was performed to char-acterize the DOX/α-cyclodextrin complex. Finally, the in-vitro drug release and modeling, morphological properties, and cellular cytotoxic effects were also evaluated. Results:: The stability of DOX was improved with complex than pure DOX. The main advantage of the complex is the al-most complete release (96.31 ± 2.56 %) of the drug within 14 days of the implant, whereas in the formulation containing the pure DOX and the physical mixture the DOX with α-cyclodextrin release is reached to 70.18 ± 3.61 % and 77.03 ± 3.56 %, respectively. This trend is due to elevate of DOX stability in the DOX/ α-cyclodextrin complex form within PLGA implant that confirmed by the results of stability. Conclusion:: Our results were indicative that the formulation containing DOX/α-cyclodextrin complex was biocompatible and sustained-release with minimum initial burst release.

Investigation of the local delivery of an intelligent chitosan-based 188Re thermosensitive in situ-forming hydrogel in an orthotopic hepatoma-bearing rat model

2013 ◽  
Vol 299 (1) ◽  
pp. 31-40 ◽  
Author(s):  
Feng-Yun J. Huang ◽  
Guo-Yi Gan ◽  
Wan-Yu Lin ◽  
Ling-Kuen Huang ◽  
Tsai-Yueh Luo ◽  
...  
Keyword(s):  
Rat Model ◽  
Local Delivery ◽  
In Situ Forming

Bleached Shellac as an Alternative Polymeric Matrix for In Situ Microparticle

2015 ◽  
Vol 659 ◽  
pp. 8-12
Author(s):  
Pitsiree Praphanwittaya ◽  
Thawatchai Phaechamud
Keyword(s):  
Droplet Size ◽  
Phosphate Buffer ◽  
Emulsion Droplet ◽  
Doxycycline Hyclate ◽  
Glyceryl Monostearate ◽  
Natural Resin ◽  
Regular Shape ◽  
External Phase ◽  
Bleached Shellac

Bleached shellac (BS), a biodegradable natural resin purified from insect lac, has been used in a varity of controlled drug delivery systems. Nevertheless, there were negligible researches explored the potential of it as in injectable in situ microparticles (ISM) applications. The goal of this study was to utilize BS to form ISM (shellac-solution dispersed into an external olive oil phase, as o/o emulsion) prepared by two-syringe technique. Addition of glyceryl monostearate (GMS) as stabilizer obviously decreased the emulsion droplet size. ISM emulsion comprising 5% w/w GMS in external phase could form into droplets and precipitate in form of microparticles after exposure to phosphate buffer. 2-Pyrrolidone was the most appropriate solvent to form massive microparticles with regular shape especially at ratio of 7:3 external:internal phases. ISM transformation was occurred after exposure to phosphate buffer and tended to reduce the droplet size when ratio of external phase was higher than 50%. Incorporation of doxycycline hyclate did not influence the amount and size of ISM. Therefore shellac exhibited as an alternative polymer matrix for ISM which higher amount of GMS could reduce the size of emulsion droplet and volume phase ratio seriously influenced on emulsion size and ISM formation.

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