COX-2 Induces IL-11 Production in Human Breast Cancer Cells

2006 ◽  
Vol 131 (2) ◽  
pp. 267-275 ◽  
Author(s):  
Balraj Singh ◽  
Jacob A. Berry ◽  
Angela Shoher ◽  
Anthony Lucci
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Cox 2

46: American Ginseng Inhibits Induced COX-2 and NFKB Activation in Human Breast Cancer Cells

2009 ◽  
Vol 151 (2) ◽  
pp. 192
Author(s):  
E.A. Peralta ◽  
L.L. Murphy ◽  
S. Louis ◽  
J. Minnis ◽  
G.L. Dunnington
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
American Ginseng ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Nfkb Activation ◽  
Cox 2

scholarly journals 15-Deoxy-Δ12,14-prostaglandin J2 Upregulates VEGF Expression via NRF2 and Heme Oxygenase-1 in Human Breast Cancer Cells

Cells ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 526
Author(s):  
Eun-Hee Kim ◽  
Su-Jung Kim ◽  
Hye-Kyung Na ◽  
Wonshik Han ◽  
Nam-Jung Kim ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Heme Oxygenase ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Heme Oxygenase 1 ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Vegf Expression ◽  
Cox 2

There is a plethora of evidence to support that inflammation is causally linked to carcinogenesis. Cyclooxygenase-2 (COX-2), a rate-limiting enzyme in the biosynthesis of prostaglandins, is inappropriately overexpressed in various cancers and hence recognized as one of the hallmarks of chronic inflammation-associated malignancies. However, the mechanistic role of COX-2 as a link between inflammation and cancer remains largely undefined. In this study, we found that 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), one of the final products of COX-2, induced upregulation of vascular endothelial growth factor (VEGF) and capillary formation and migration through nuclear factor erythroid 2-related factor 2 (NRF2)-dependent heme oxygenase-1 (HO-1) induction in MCF-7 cells. Analysis of the publicly available TCGA data set showed that high mRNA levels of both COX-2 and NRF2 correlated with the poor clinical outcomes in breast cancer patients. Moreover, human tissue analysis showed that the levels of 15d-PGJ2 as well the expression of COX-2, NRF2, and HO-1 were found to be increased in human breast cancer tissues. In conclusion, the elevated levels of 15d-PGJ2 during inflammatory response activate VEGF expression through NRF2-driven induction of HO-1 in human breast cancer cells, proposing a novel mechanism underlying the oncogenic function of 15d-PGJ2.

Inhibition of PKC-Induced COX-2 and IL-8 Expression in Human Breast Cancer Cells by Glucosamine

2015 ◽  
Vol 230 (9) ◽  
pp. 2240-2251 ◽  
Author(s):  
Wan-Yu Chou ◽  
Kun-Han Chuang ◽  
David Sun ◽  
Yu-Hsiu Lee ◽  
Pu-Hong Kao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Cox 2

scholarly journals Down-regulation of cyclooxygenase-2 (COX-2) by cannabidiolic acid in human breast cancer cells

2014 ◽  
Vol 39 (5) ◽  
pp. 711-716 ◽  
Author(s):  
Shuso Takeda ◽  
Hiroyuki Okazaki ◽  
Eriko Ikeda ◽  
Satomi Abe ◽  
Yasushi Yoshioka ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Cyclooxygenase 2 ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Down Regulation ◽  
Cannabidiolic Acid ◽  
Cox 2

Silibinin prevents TPA-induced MMP-9 expression by down-regulation of COX-2 in human breast cancer cells

2009 ◽  
Vol 126 (2) ◽  
pp. 252-257 ◽  
Author(s):  
Sangmin Kim ◽  
Sung Hoon Kim ◽  
Sung Mo Hur ◽  
Se-Kyung Lee ◽  
Wan Wook Kim ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Down Regulation ◽  
Cox 2
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