scholarly journals Short- and long-term outcomes in patients undergoing valve surgery with end-stage renal failure receiving chronic hemodialysis

2012 ◽  
Vol 144 (1) ◽  
pp. 117-123 ◽  
Author(s):  
Vinod H. Thourani ◽  
Eric L. Sarin ◽  
Patrick D. Kilgo ◽  
Omar M. Lattouf ◽  
John D. Puskas ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Hemodialysis ◽  
Valve Surgery ◽  
Long Term Outcomes ◽  
End Stage Renal Failure ◽  
Short And Long Term ◽  
End Stage

Short- and long-term biological variation of cardiac troponin I in healthy individuals, and patients with end-stage renal failure requiring haemodialysis or cardiomyopathy

2020 ◽  
Vol 58 (11) ◽  
pp. 1941-1949
Author(s):  
Nick S. R. Lan ◽  
Lan T. Nguyen ◽  
Samuel D. Vasikaran ◽  
Catherine Wilson ◽  
Jacqueline Jonsson ◽  
...  
Keyword(s):  
Renal Failure ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Biological Variation ◽  
Healthy Individuals ◽  
Short Term ◽  
End Stage Renal Failure ◽  
Short And Long Term ◽  
End Stage

AbstractObjectivesHigh-sensitivity (hs) cardiac troponin (cTn) assays can quantitate small fluctuations in cTn concentration. Determining biological variation allows calculation of reference change values (RCV), to define significant changes. We assessed the short- and long-term biological variation of cardiac troponin I (cTnI) in healthy individuals and patients with renal failure requiring haemodialysis or cardiomyopathy.MethodsPlasma samples were collected hourly for 4 h and weekly for seven further weeks from 20 healthy individuals, 9 renal failure patients and 20 cardiomyopathy patients. Pre- and post-haemodialysis samples were collected weekly for 7 weeks. Samples were analysed using a hs-cTnI assay (Abbott Alinity ci-series). Within-subject biological variation (CVI), analytical variation (CVA) and between-subject biological variation (CVG) was used to calculate RCVs and index of individuality (II).ResultsFor healthy individuals, CVI, CVA, CVG, RCV and II values were 8.8, 14.0, 43.1, 45.8% and 0.38 respectively for short-term, and 41.4, 14.0, 25.8, 121.0% and 1.69 for long-term. For renal failure patients, these were 2.6, 5.8, 50.5, 17.6% and 0.30 respectively for short-term, and 19.1, 5.8, 11.2, 55.2% and 1.78 for long-term. For cardiomyopathy patients, these were 4.2, 10.0, 65.9, 30.0% and 0.16 respectively for short-term, and 17.5, 10.0, 63.1, 55.8% and 0.32 for long-term. Mean cTnI concentration was lower post-haemodialysis (15.2 vs. 17.8 ng/L, p < 0.0001), with a 16.9% mean relative change.ConclusionsThe biological variation of cTnI is similar between end-stage renal failure and cardiomyopathy patients, but proportionately greater in well-selected healthy individuals with very low baseline cTnI concentrations.

scholarly journals Cardiac Troponin T Predicts Long-Term Outcomes in Hemodialysis Patients

2001 ◽  
Vol 47 (3) ◽  
pp. 412-417 ◽  
Author(s):  
Daylily S Ooi ◽  
Deborah Zimmerman ◽  
Janet Graham ◽  
George A Wells
Keyword(s):  
Troponin I ◽  
Troponin T ◽  
Hemodialysis Patients ◽  
Chronic Hemodialysis ◽  
Peripheral Vascular ◽  
Long Term Outcomes ◽  
All Cause Mortality ◽  
End Stage

Abstract Background: Increased plasma troponin T (cTnT), but not troponin I (cTnI), is frequently observed in end-stage renal failure patients. Although generally considered spurious, we previously reported an associated increased mortality at 12 months. Methods: We studied long-term outcomes in 244 patients on chronic hemodialysis for up to 34 months, correlating the outcomes to plasma cTnT in routine predialysis samples. In addition, subsequent plasma samples at least 1 year later and within 6 months of data analysis were available in 97 patients and were used to identify patients with increasing plasma cTnT. The endpoints used were death and new or worsening coronary, cerebro-, and peripheral vascular disease and neuropathy. Results: Transplantation occurred more frequently in patients with low initial cTnT: 31%, 13%, and 3% in the groups with cTnT &lt;0.010, 0.010–0.099, and ≥0.100 μg/L, respectively. In the same groups, total deaths occurred in 6%, 43%, and 59% and cardiac deaths in 0%, 14%, and 24% of patients. In patients with follow-up samples, the group with increasing cTnT had a significantly increased death (relative risk, 2.0; P = 0.028). The increase was mainly in cardiac and sudden deaths. Conclusions: Higher plasma cTnT predicts long-term all-cause mortality in hemodialysis patients, even at concentrations &lt;0.100 μg/L, as does an increasing cTnT concentration over time.

Biopsychosocial aspects of long-term survival on end-stage renal failure therapy

1989 ◽  
Vol 19 (4) ◽  
pp. 945-954 ◽  
Author(s):  
Ralph Shulman ◽  
John D. E. Price ◽  
John Spinelli
Keyword(s):  
Renal Failure ◽  
Beck Depression Inventory ◽  
Routine Care ◽  
Renal Transplants ◽  
Term Survival ◽  
End Stage Renal Failure ◽  
End Stage ◽  
The Impact

SYNOPSISAt ten-years follow-up of 64 haemodialysis patients, 43 had died and 21 were alive, twelve with cadaver renal transplants and nine on haemodialysis. Examination of the influence of psychological, demographic, physical and biochemical factors revealed the Beck Depression Inventory and age as the two most important predictors of survival. The behaviour of the patient was directly responsible for five (11·6%) of the deaths, by suicide in three cases and dietary noncompliance in two cases. Hypothetical mechanisms linking depression with reduced survival have been reviewed. As the impact of depression on survival was maximal in the first few years of dialysis, monitoring for depression should be incorporated into routine care from the start of dialysis together with evaluative interventions that might enhance survival.

scholarly journals SHORT AND LONG-TERM OUTCOMES OF DIFFERENT REVASCULARIZATION STRATEGIES IN PATIENTS WITH END STAGE RENAL DISEASE ON HEMODIALYSIS

2012 ◽  
Vol 59 (13) ◽  
pp. E549 ◽  
Author(s):  
Abel E. Moreyra ◽  
Peter Hynes ◽  
Yingzi Deng ◽  
Nora M. Cosgrove ◽  
Christopher Brown ◽  
...  
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Long Term Outcomes ◽  
Short And Long Term ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Heart surgery in patients on chronic dialysis

2013 ◽  
Vol 66 (1-2) ◽  
pp. 64-69 ◽  
Author(s):  
Dragana Unic-Stojanovic ◽  
Miroslav Milicic ◽  
Petar Vukovic ◽  
Srdjan Babic ◽  
Miomir Jovic
Keyword(s):  
Renal Failure ◽  
Cardiac Surgery ◽  
Cardiopulmonary Bypass ◽  
Coronary Artery ◽  
Coronary Artery Bypass Grafting ◽  
Artery Bypass ◽  
Valve Surgery ◽  
Bypass Grafting ◽  
End Stage Renal Failure ◽  
End Stage

Introduction. Patients on dialysis for end-stage renal failure are subjected to cardiac surgery with increasing frequency. End-stage renal failure is known to be an important risk factor for complications of cardiac operations performed with cardiopulmonary bypass. The aim of this study was to determine the impact of preoperative clinical status and operative variables on perioperative morbidity and mortality in hemodialysis dependent patients subjected to a cardiac surgery. Material and Methods. The following operative variables were examined: urgency, type and duration of surgery and duration of extracorporeal circulation. The study is a retrospective analysis of consecutive patients with end-stage renal failure dependent on maintenance hemodialysis who underwent cardiac surgery during four years. Results. The study included 46 patients. Operations performed included isolated coronary artery bypass grafting (CABG, n = 24), valve surgery alone (n = 6), and combined valve surgery or coronary artery bypass grafting and valve surgery (n = 16). The perioperative mortality rate was 13% with four fatal outcomes in patients who had undergone combined cardiac surgery. We found age > 70 years, preoperative New York Heart Association class IV, preoperative anemia, combined surgery and emergent surgery to be associated with a higher relative risk for perioperative death. Conclusion. Patients on dialysis have an increased morbidity and mortality following cardiac surgery; however, we believe that end-stage renal failure should not be regarded as a contraindication to cardiac surgery or cardiopulmonary bypass.

IgA nephropathy: common nephritis leading to end-stage renal failure

1994 ◽  
Vol 17 (9) ◽  
pp. 457-460 ◽  
Author(s):  
K.N. Lai ◽  
A.Y.M. Wang
Keyword(s):  
Renal Failure ◽  
Iga Nephropathy ◽  
Significant Proportion ◽  
Specific Treatment ◽  
Prognostic Indicators ◽  
Initial Report ◽  
End Stage Renal Failure ◽  
High Incidence ◽  
End Stage

IgA nephropathy (IgAN) characterized by mesangial proliferative glomerulonephritis with predominant mesangial IgA deposition is the commonest glomerulonephritis worldwide. In contrast to the initial report indicated a favorable prognosis, subsequent reports have shown a highly variable outcome leading to end-stage renal failure (ESRF) in a significant proportion of patients. Many centers report a high incidence (ranging from 10-22%) of patients with idiopathic IgAN amongst the total population of patients on maintenance dialysis. Most of these patients develop ESRF at their middle-age and hence, will pose a significant and important workload in the dialysis and transplantation programme. Because IgAN is a disease with a variable rate of progression leading to chronic renal failure amongst younger patients and with neither effective nor specific treatment, identification of the clinical and pathologic prognostic indicators for these patients is of paramount importance in planning the long-term renal replacement program.

scholarly journals Long‐term impact of renal transplantation on carotid artery properties and on ventricular hypertrophy in end‐stage renal failure patients

2002 ◽  
Vol 17 (4) ◽  
pp. 645-651 ◽  
Author(s):  
Jose Jayme G. De Lima ◽  
Marcelo Luis C. Vieira ◽  
Luis Fernando Viviani ◽  
Caio Jorge Medeiros ◽  
Luis Estevan Ianhez ◽  
...  
Keyword(s):  
Renal Failure ◽  
Renal Transplantation ◽  
Carotid Artery ◽  
Ventricular Hypertrophy ◽  
End Stage Renal Failure ◽  
Long Term Impact ◽  
End Stage
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