Analysis of the Revised Heart Allocation Policy and the Impact of Increased Mechanical Circulatory Support on Survival

2021 ◽  
Author(s):  
Stefan Elde ◽  
Hao He ◽  
Bharathi Lingala ◽  
Mike Baiocchi ◽  
Hanjay Wang ◽  
...  
Keyword(s):  
Mechanical Circulatory Support ◽  
Circulatory Support ◽  
Allocation Policy ◽  
The Impact

scholarly journals The Impact of a High-risk Psychosocial Assessment on Outcomes After Durable Mechanical Circulatory Support

ASAIO Journal ◽  
2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Michelle M. Kittleson ◽  
Heather Barone ◽  
Robert M. Cole ◽  
megan Olman ◽  
Alisa Fishman ◽  
...  
Keyword(s):  
High Risk ◽  
Mechanical Circulatory Support ◽  
Psychosocial Assessment ◽  
Circulatory Support ◽  
The Impact

scholarly journals Mechanical shear stress and leukocyte phenotype and function: Implications for ventricular assist device development and use

2018 ◽  
Vol 42 (3) ◽  
pp. 133-142 ◽  
Author(s):  
Gemma Radley ◽  
Sabrina Ali ◽  
Ina Laura Pieper ◽  
Catherine A Thornton
Keyword(s):  
Heart Failure ◽  
Shear Stress ◽  
Mechanical Circulatory Support ◽  
Circulatory Support ◽  
Modern World ◽  
Mechanical Trauma ◽  
Ventricular Assist ◽  
End Stage ◽  
And Function ◽  
The Impact

Heart failure remains a disease of ever increasing prevalence in the modern world. Patients with end-stage heart failure are being referred increasingly for mechanical circulatory support. Mechanical circulatory support can assist patients who are ineligible for transplant and stabilise eligible patients prior to transplantation. It is also used during cardiopulmonary bypass surgery to maintain circulation while operating on the heart. While mechanical circulatory support can stabilise heart failure and improve quality of life, complications such as infection and thrombosis remain a common risk. Leukocytes can contribute to both of these complications. Contact with foreign surfaces and the introduction of artificial mechanical shear stress can lead to the activation of leukocytes, reduced functionality and the release of pro-inflammatory and pro-thrombogenic microparticles. Assessing the impact of mechanical trauma to leukocytes is largely overlooked in comparison to red blood cells and platelets. This review provides an overview of the available literature on the effects of mechanical circulatory support systems on leukocyte phenotype and function. One purpose of this review is to emphasise the importance of studying mechanical trauma to leukocytes to better understand the occurrence of adverse events during mechanical circulatory support.

scholarly journals Mechanical circulatory support in refractory cardiogenic shock due to influenza virus-related myocarditis

2020 ◽  
Vol 56 (3) ◽  
pp. 2000925 ◽  
Author(s):  
Jan-Thorben Sieweke ◽  
Muharrem Akin ◽  
Sebastian Stetskamp ◽  
Christian Riehle ◽  
Danny Jonigk ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Cardiogenic Shock ◽  
Mechanical Circulatory Support ◽  
Influenza Virus Infection ◽  
Axial Flow ◽  
Circulatory Support ◽  
Influenza B ◽  
Refractory Cardiogenic Shock ◽  
Va Ecmo ◽  
The Impact

BackgroundThere is scarce evidence for mechanical circulatory support (MCS) in patients with influenza-related myocarditis complicated by refractory cardiogenic shock (rCS). We sought to investigate the impact of MCS using combined veno-arterial extracorporeal membrane oxygenation (VA-ECMO) and micro-axial flow pumps (the ECMELLA concept) in influenza-related myocarditis complicated by rCS.MethodsThis is a prospective, observational analysis from the single centre HAnnover Cardiac Unloading REgistry (HACURE) from two recent epidemic influenza seasons. We analysed patients with verified influenza-associated myocarditis complicated by rCS who were admitted to our intensive care unit (ICU) on MCS. Subsequently, we performed a propensity score (PS) matched analysis to patients with acute myocardial infarction (AMI) complicated by rCS and non-ischaemic cardiomyopathy (DCM) related rCS.ResultsWe describe a series of seven patients with rCS-complicated influenza-related myocarditis (mean age 56±10 years, 58% male, influenza A (n=2)/influenza B (n=5)). No patient had been vaccinated prior to the influenza season. MCS was provided using combined VA-ECMO and Impella micro-axial flow pump. In two patients with out-of-hospital cardiac arrest, VA-ECMO had been implanted for extracorporeal cardiopulmonary resuscitation. All patients died within 18 days of hospital admission. By PS-based comparison to patients with AMI- or DCM-related rCS and combined MCS, 30-day mortality was significantly higher in influenza-related rCS.ConclusionDespite initial stabilisation with combined MCS in patients with rCS-complicated influenza-related myocarditis, the detrimental course of shock could not be stopped and all patients died. Influenza virus infection potentially critically affects other organs besides the heart, leading to irreversible end-organ damage that MCS cannot compensate for and, therefore, results in a devastating outcome.

The Pediatric Mechanical Circulatory Support Program in Innsbruck, Austria, and the Impact of Such Programs on Lack of Donor Hearts in Europe

ASAIO Journal ◽  
2007 ◽  
Vol 53 (6) ◽  
pp. 696-700 ◽  
Author(s):  
Ulrich Schweigmann ◽  
Herwig Antretter ◽  
Peter Mair ◽  
Corinna Velik-Salchner ◽  
Josef Margreiter ◽  
...  
Keyword(s):  
Mechanical Circulatory Support ◽  
Support Program ◽  
Circulatory Support ◽  
The Impact

scholarly journals The impact of peripheral arterial disease on patients with mechanical circulatory support

2020 ◽  
Vol 28 ◽  
pp. 100509 ◽  
Author(s):  
Waqas Ullah ◽  
Yasar Sattar ◽  
Fahed Darmoch ◽  
Yasser Al-khadra ◽  
Tanveer Mir ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Mechanical Circulatory Support ◽  
Arterial Disease ◽  
Circulatory Support ◽  
Peripheral Arterial ◽  
The Impact
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