Racial Differences Among Boys With Testicular Germ Cell Tumors in the United States

2008 ◽  
Vol 179 (5) ◽  
pp. 1961-1965 ◽  
Author(s):  
Thomas J. Walsh ◽  
Benjamin J. Davies ◽  
Mary S. Croughan ◽  
Peter R. Carroll ◽  
Paul J. Turek
Cancer ◽  
2002 ◽  
Vol 97 (1) ◽  
pp. 63-70 ◽  
Author(s):  
Katherine A. McGlynn ◽  
Susan S. Devesa ◽  
Alice J. Sigurdson ◽  
Linda M. Brown ◽  
Lilian Tsao ◽  
...  

Andrology ◽  
2014 ◽  
Vol 3 (1) ◽  
pp. 13-18 ◽  
Author(s):  
A. A. Ghazarian ◽  
B. Trabert ◽  
S. S. Devesa ◽  
K. A. McGlynn

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. e15554-e15554
Author(s):  
Brandon David Bernard ◽  
Sarah C. Markt ◽  
Laurence Albiges ◽  
Rowan Miller ◽  
Clair Beard ◽  
...  

2005 ◽  
Vol 23 (24) ◽  
pp. 5757-5761 ◽  
Author(s):  
Katherine A. McGlynn ◽  
Susan S. Devesa ◽  
Barry I. Graubard ◽  
Philip E. Castle

Purpose There has been marked disparity in the incidence of testicular germ cell tumors (TGCT) among white and black men for a number of decades in the United States. Since at least the beginning of the Surveillance, Epidemiology, and End Results (SEER) Program in 1973, incidence rates among white men have been five times higher than rates among black men. In addition, rates among white men have been increasing, whereas rates among black men have remained stable. However, a recent examination of ethnic-specific rates suggested that the incidence among black men may have begun to change in the 1990s. Patients and Methods TGCT incidence data from nine registries of the SEER Program were analyzed for the years 1973 to 2001. Trends were examined separately for seminoma and nonseminoma. Results Analyses found that the incidence of TGCT began to increase among black men between the 1988 to 1992 and 1993 to 1997 periods. Before that time, incidence among black men had decreased by 14.8%. Between 1988 to 1992 and 1998 to 2001, however, the incidence increased by 100%, with the incidence of seminoma increasing twice as much (124.4%) as the incidence of nonseminoma (64.3%). Over the 29-year time period, there was no evidence of a change in the proportion of tumors diagnosed at earlier stages among black men. In contrast, the proportion of tumors diagnosed at localized stages significantly increased among white men. Conclusion The incidence of TGCT among black men has increased since 1988 to 1992. Although the reasons for this increase are unclear, screening and earlier diagnosis of TGCT do not seem to be factors.


2005 ◽  
Vol 16 (6) ◽  
pp. 651-656 ◽  
Author(s):  
V. Paul. Doria-Rose ◽  
Mary Lou Biggs ◽  
Noel S. Weiss

2001 ◽  
Vol 40 (4) ◽  
pp. 536-540 ◽  
Author(s):  
Finn Edler von Eyben ◽  
Ebbe Lindegaard Madsen ◽  
Ole Blaabjerg ◽  
Per Hyltoft Petersen ◽  
Hans von der Maase ◽  
...  

2018 ◽  
Vol 18 (10) ◽  
pp. 967-978 ◽  
Author(s):  
Katarina Kalavska ◽  
Vincenza Conteduca ◽  
Ugo De Giorgi ◽  
Michal Mego

Testicular germ cell tumors (TGCTs) represent the most common malignancy in men aged 15-35. Due to these tumors’ biological and clinical characteristics, they can serve as an appropriate system for studying molecular mechanisms associated with cisplatin-based treatment resistance. This review describes treatment resistance from clinical and molecular viewpoints. Cisplatin resistance is determined by various biological mechanisms, including the modulation of the DNA repair capacity of cancer cells, alterations to apoptotic cell death pathways, deregulation of gene expression pathways, epigenetic alterations and insufficient DNA binding. Moreover, this review describes TGCTs as a model system that enables the study of the cellular features of cancer stem cells in metastatic process and describes experimental models that can be used to study treatment resistance in TGCTs. All of the abovementioned aspects may help to elucidate the molecular mechanisms underlying cisplatin resistance and may help to identify promising new therapeutic targets.


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