MP47-11 CANDIDATE BIOMARKER FOR BONE MORPHOGENETIC PROTEIN 2 PREDICTS RENAL CELL CARCINOMA PROGRESSION VIA ITS PROMOTER CPG HYPERMETHYLATION

2015 ◽  
Vol 193 (4S) ◽  
Author(s):  
Yozo Mitsui ◽  
Naoko Arichi ◽  
Miho Hiraki ◽  
Hiroaki Yasumoto ◽  
Shinichiro Fukuhara ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Bone Morphogenetic Protein ◽  
Renal Cell ◽  
Bone Morphogenetic Protein 2 ◽  
Morphogenetic Protein ◽  
Cpg Hypermethylation

INVOLVEMENT OF BONE MORPHOGENETIC PROTEIN 2 IN OSSIFICATION OF RENAL CELL CARCINOMA

2004 ◽  
Vol 172 (2) ◽  
pp. 475-476 ◽  
Author(s):  
MUTSUSHI YAMASAKI ◽  
TAKEO NOMURA ◽  
HIROMITSU MIMATA ◽  
YOSHIO NOMURA
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Bone Morphogenetic Protein ◽  
Renal Cell ◽  
Bone Morphogenetic Protein 2 ◽  
Morphogenetic Protein

CpG Hypermethylation of the UCHL1 Gene Promoter is Associated With Pathogenesis and Poor Prognosis in Renal Cell Carcinoma

2008 ◽  
Vol 180 (1) ◽  
pp. 343-351 ◽  
Author(s):  
Ichiro Kagara ◽  
Hideki Enokida ◽  
Kazumori Kawakami ◽  
Ryouichirou Matsuda ◽  
Kazuki Toki ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Poor Prognosis ◽  
Gene Promoter ◽  
Cpg Hypermethylation ◽  
Uchl1 Gene

Inactivation of p16 by CpG hypermethylation in renal cell carcinoma

2008 ◽  
Vol 26 (3) ◽  
pp. 239-245 ◽  
Author(s):  
Marta Vidaurreta ◽  
M. Luisa Maestro ◽  
M. Teresa Sanz-Casla ◽  
Carmen Maestro ◽  
Sara Rafael ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Cpg Hypermethylation

scholarly journals Clear cell renal cell carcinoma with heterotopic bone formation: A case report and literature review

2019 ◽  
Vol 5 (2) ◽  
pp. 16
Author(s):  
Estelle Oertling ◽  
Cacey Peters ◽  
Robert Wood ◽  
Jonathan Silberstein ◽  
Andrew B. Sholl ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Bone Formation ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Bone Morphogenetic Protein 2 ◽  
Osseous Metaplasia ◽  
Heterotopic Bone ◽  
Heterotopic Bone Formation ◽  
Tissue Ischemia

The phenomenon of heterotopic bone formation (osseous metaplasia) is defined as an abnormal ossification of non-skeletal tissues and does represent a rare occurrence in the renal cell carcinoma setting. We describe a case of a 40-year old man with bilateral renal cell carcinomas of the histological clear cell subtype, with the right-sided renal cell carcinoma demonstrating heterotopic bone formation, as well as the presence of intratumoral adipose tissue. The etiology of bone formation in a renal cell carcinoma is unclear, but possible explanations include a response to tissue ischemia and the expression of Bone Morphogenetic Protein 2. The detection of these rare morphologic variations is of paramount importance, not to be mistaken as sarcomatoid transformation and renal sinus fat invasion, which would advance the pathologic tumor stage and aggressiveness of the disease. 

CPG HYPERMETHYLATION OF UCHL1 CONTRIBUTES PATHOGENESIS AND POOR PROGNOSIS IN RENAL CELL CARCINOMA

2009 ◽  
Vol 181 (4S) ◽  
pp. 106-107
Author(s):  
Ichiro Kagara ◽  
Hideki Enokida ◽  
Katsuhisa Mori ◽  
Kenryu Nishiyama ◽  
Naohiko Seki ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Poor Prognosis ◽  
Cpg Hypermethylation
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