PD35-07 USE OF STROMAL VASCULAR FRACTION OF ADIPOSE TISSUE IN PATIENTS WITH VASCULOGENIC ERECTILE DYSFUNCTION: EVALUATION OF CLINICAL EFFECTIVENESS AND SAFETY (PRELIMINARY RESULTS: PHASES 1-2, 6 MONTHS OF FOLLOW-UP) NCT02472431

Osteoarthritis (OA) is one of the most common debilitating disorders among the elderly population. At present, there is no definite cure for the underlying causes of OA. However, adipose tissue-derived stem cells (ADSCs) in the form of stromal vascular fraction (SVF) may offer an alternative at this time. ADSCs are one type of mesenchymal stem cells that have been utilized and have demonstrated an ability to regenerate cartilage. ADSCs have been shown to regenerate cartilage in a variety of animal models also. Non-culture-expanded ADSCs, in the form of SVF along with platelet rich plasma (PRP), have recently been used in humans to treat OA and other cartilage abnormalities. These ADSCs have demonstrated effectiveness without any serious side effects. However, due to regulatory issues, only ADSCs in the form of SVF are currently allowed for clinical uses in humans. Culture-expanded ADSCs, although more convenient, require clinical trials for a regulatory approval prior to uses in clinical settings. Here we present a systematic review of currently available clinical studies involving ADSCs in the form of SVF and in the culture-expanded form, with or without PRP, highlighting the clinical effectiveness and safety in treating OA.

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Penile revascularization in vasculogenic erectile dysfunction (ED): long–term follow–up

Yearbook of Urology ◽

10.1016/j.yuro.2012.05.053 ◽

2012 ◽

Vol 2012 ◽

pp. 127-128

Author(s):

A.W. Shindel

Keyword(s):

Erectile Dysfunction ◽

Penile Revascularization ◽

Long Term Follow Up ◽

Vasculogenic Erectile Dysfunction

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Venous leak and erectile dysfunction – an important differential

Journal of Clinical Urology ◽

10.1177/2051415819847318 ◽

2019 ◽

Vol 13 (1) ◽

pp. 33-39

Author(s):

Rahim Kaba ◽

Ian Pearce

Keyword(s):

Erectile Dysfunction ◽

Surgical Management ◽

Venous Drainage ◽

Review Article ◽

Significant Decline ◽

Management Options ◽

Level Of Evidence ◽

Significant Challenge ◽

Vasculogenic Erectile Dysfunction

Congenital venous leak or veno-occlusive dysfunction is an important cause of vasculogenic erectile dysfunction, posing a significant challenge to urologists. To date no medical therapy exists for the treatment of this condition, whilst surgical management options are based on resection or ligation of the offending venous drainage with a significant decline in efficacy with follow-up exceeding 12 months, perhaps as a consequence of collateral drainage. This review article highlights the importance of veno-occlusive dysfunction. We discuss the pathophysiology, investigations and the required treatment. Level of evidence: Not applicable for this multicentre audit.

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Penile revascularization in vasculogenic erectile dysfunction (ED): long-term follow-up

BJU International ◽

10.1111/j.1464-410x.2011.10293.x ◽

2011 ◽

Vol 109 (1) ◽

pp. 109-115 ◽

Cited By ~ 23

Author(s):

Onder Kayıgil ◽

Emrah Okulu ◽

Mustafa Aldemir ◽

Efe Onen

Keyword(s):

Erectile Dysfunction ◽

Penile Revascularization ◽

Long Term Follow Up ◽

Vasculogenic Erectile Dysfunction

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Low-intensity extracorporeal shock wave therapy of vasculogenic erectile dysfunction - three-week treatment in a cohort of North Italian patients

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh180516043a ◽

2018 ◽

Vol 146 (9-10) ◽

pp. 549-553 ◽

Cited By ~ 1

Author(s):

Goran Arandjelovic ◽

Fedra Gottardo ◽

Ivan Ignjatovic

Keyword(s):

Shock Wave ◽

Erectile Dysfunction ◽

Doppler Ultrasound ◽

Erectile Function ◽

Extracorporeal Shock Wave Therapy ◽

Shock Wave Therapy ◽

Low Intensity ◽

Extracorporeal Shock Wave ◽

Vasculogenic Erectile Dysfunction

Introduction/Objective. Although phosphodiesterase 5 (PDE 5) inhibitors represent the gold standard for medical treatment of erectile dysfunction (ED), they are not curative. Over the recent years, low-intensity extracorporeal shock wave therapy (LI-ESWT) has been proposed as a valid non-invasive therapy approach for ED. The aim of our work is to assess the shortened, three-week low-intensity extracorporeal shock wave therapy of vasculogenic ED. Methods. The study involved 32 patients with an International Index of Erectile Function (IIEF) score between 5 and 20, and whose vasculogenic ED had been proven through Doppler ultrasound. All the patients had a washout period of one month after previous therapy and agreed to discontinue the PDE5-I therapy during the follow-up. The LI-ESWT was applied for three weeks, twice weekly, without repeating. The patients were evaluated at baseline, after one, three, and six months with the IIEF, Doppler ultrasound, and the Beck Depression Inventory. Results. All investigated parameters (International Index of Erectile Function, Beck Depression Inventory and penile Doppler ultrasound parameters) showed statistically significant improvement just one month after the treatment, compared to pre-treatment values, in all investigated domains. The international index of erectile function passed from baseline values of 12.75 ? 4.62 to 14.87 ? 5.04 at one month after treatment (p < 0.01). This trend remained positive in IIEF and all the parameters tested at the three-month and six-month follow-up. Conclusion. The shortened three-week low-intensity shock wave treatment of vasculogenic erectile dysfunction proved to be clinically effective.

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Cartilage Regeneration in Humans with Adipose Tissue-Derived Stem Cells and Adipose Stromal Vascular Fraction Cells: Updated Status

International Journal of Molecular Sciences ◽

10.3390/ijms19072146 ◽

2018 ◽

Vol 19 (7) ◽

pp. 2146 ◽

Cited By ~ 20

Author(s):

Jaewoo Pak ◽

Jung Lee ◽

Natalie Pak ◽

Yoon Pak ◽

Kwang Park ◽

...

Keyword(s):

Stem Cells ◽

Adipose Tissue ◽

Gradual Increase ◽

Stromal Vascular Fraction ◽

Cartilage Regeneration ◽

Clinical Effectiveness ◽

Clinical Settings ◽

Biological Mechanisms ◽

Bone Marrow Stimulation ◽

Number Of Publications

Adipose tissue-derived stem cells (ASCs) in the form of stromal vascular fraction (SVF) and cultured expansion have been applied in clinical settings in some countries to treat osteoarthritis (OA) of knees, one of the most common debilitating, incurable disorders. Since the first report of successful cartilage-like tissue regeneration with autologous adipose SVF containing ASCs, there has been a gradual increase in the number of publications confirming such results. Thus far, most of the reports have been limited to treatments of OA of knees. Recently, successful applications of adipose SVF in treating OA of ankles and hips have been reported. In addition, several groups have reported modified methods of applying adipose SVF, such as combining bone marrow stimulation with adipose SVF or adding additional extracellular matrix (ECM) in treating OA. Here, we present an updated, systematic review of clinical effectiveness and safety in treating OA of knees, ankles, and one hip since 2016 using ASCs in the form of adipose SVF or in cultured expansion, along with a description and suggestion of potential biological mechanisms of cartilage regeneration.

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(P1-95) Clinical Effectiveness of Psychological First Aid Training among Emergency Responders in Chinese Population: Preliminary Results of 3-Month Follow-Up

Prehospital and Disaster Medicine ◽

10.1017/s1049023x11004274 ◽

2011 ◽

Vol 26 (S1) ◽

pp. s129-s130

Author(s):

E.Y.L. Cheung ◽

E.Y.Y. Chan ◽

C.L.Y. Lin ◽

P.P.Y. Lee

Keyword(s):

Mental Health ◽

Clinical Effectiveness ◽

First Aid ◽

Screening Tools ◽

Controlled Study ◽

Control Group ◽

Psychological First Aid ◽

Preliminary Results ◽

Emergency Responders

BackgroundPsychological First Aid (PFA) has become the choice of mental health intervention and integration with the current disaster relief protocols during emergencies by the Institute of Medicine, NIMH and the WHO. It can be used during or immediately after disaster. People without mental health specialized training, including public health practitioners and emergency responders can learn and apply to everyone in need. Whilst being used extensively, few studies have evaluated the effectiveness of PFA and its field applicability.MethodsA prospective randomized controlled study. 800 emergency medical responders were recruited. Participants were randomly assigned to the control/intervention arms to receive a one-day training of PFA based on the protocol developed by the National Child Traumatic Stress Network (2006). A pilot study was conducted to evaluate the screening tools and training material and all training was provided by trained clinical psychologist. Repeated measures analysis of covariance was used to evaluate the efficacy of PFA program in changes in various outcome measures between PFA intervention and control group. All analyses were conducted on the intent-to-treat and completer groups. Ethical approval was approved by the CUHK-NTEC Clinical Research Ethics Committee.ResultsPreliminary results from the post-training and 3 month follow-up data indicated participants in the training group have reported a significantly more substantial knowledge in disaster mental health, improve self-efficacy in delivering help in times of emergencies, high frequency of actual helping behavior as well as better self-reported psychological well-being when compared with waitlist control group.ConclusionThis study examines and reports findings of clinical effectiveness of PFA 3 months post training in Chinese emergency responders. Preliminary results provided empirical evidences on the effectiveness of the approach.

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