Epstein-Barr Virus as a Potential Etiology of Persistent Bladder Inflammation in Human Interstitial Cystitis/Bladder Pain Syndrome

2018 ◽  
Vol 200 (3) ◽  
pp. 590-596 ◽  
Author(s):  
Jia-Fong Jhang ◽  
Yung-Hsiang Hsu ◽  
Chih-Wen Peng ◽  
Yuan-Hong Jiang ◽  
Han-Chen Ho ◽  
...  
Keyword(s):  
Interstitial Cystitis ◽  
Epstein Barr Virus ◽  
Pain Syndrome ◽  
Bladder Pain Syndrome ◽  
Bladder Pain ◽  
Barr Virus ◽  
Bladder Inflammation ◽  
Epstein Barr

scholarly journals Role of NLRP3 inflammasome in the development of bladder pain syndrome interstitial cystitis

2019 ◽  
Vol 11 ◽  
pp. 175628721881803 ◽  
Author(s):  
Karol Borys Tudrej ◽  
Tomasz Piecha ◽  
Małgorzata Kozłowska-Wojciechowska
Keyword(s):  
Interstitial Cystitis ◽  
Nlrp3 Inflammasome ◽  
Pain Syndrome ◽  
Bladder Pain Syndrome ◽  
Receptor Protein ◽  
Inflammasome Activation ◽  
Bladder Epithelium ◽  
Bladder Pain ◽  
Bladder Inflammation ◽  
Nlrp3 Inflammasome Activation

Although it has been proposed that NOD-like receptor protein 3 (NLRP3) inflammasome activation may have an important contribution to the onset of bladder pain syndrome/interstitial cystitis (BPS/IC), as of today there is still insufficient evidence to accept or to reject this hypothesis. However, taking into consideration that inflammasomes have been already shown as important mediators of cyclophosphamide-induced bladder inflammation and that some studies have also revealed human bladder epithelium expresses high levels of NLRP3, such a hypothesis seems to be reasonable. The purpose of this review is to discuss a scenario that NLRP3 inflammasome is a crucial player in the development of this disease. Identification of a novel mediator of bladder inflammation and pain could lead to emerging new therapeutic strategy and the first causative therapy.

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