scholarly journals Granulocyte-macrophage colony-stimulating factor stimulates arteriogenesis in a pig model of peripheral artery disease using clinically applicable infusion pumps

2006 ◽  
Vol 43 (6) ◽  
pp. 1263-1269 ◽  
Author(s):  
Sebastian Grundmann ◽  
Imo Hoefer ◽  
Susann Ulusans ◽  
Christoph Bode ◽  
Stephen Oesterle ◽  
...  
Keyword(s):  
Peripheral Artery Disease ◽  
Pig Model ◽  
Colony Stimulating Factor ◽  
Peripheral Artery ◽  
Infusion Pumps ◽  
Macrophage Colony Stimulating Factor ◽  
Artery Disease ◽  
Macrophage Colony ◽  
Stimulating Factor

Die Stimulation von Vorläuferzellen des Gefäßendothels zeigt keinen zum Laufbandtraining zusätzlichen Effekt auf die 6-Minuten Gehstrecke

2018 ◽  
Vol 28 (01) ◽  
pp. 4-4
Author(s):  
K. Ammer
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Colony Stimulating Factor ◽  
Peripheral Artery ◽  
Supervised Exercise ◽  
Walking Performance ◽  
Macrophage Colony Stimulating Factor ◽  
Artery Disease ◽  
Macrophage Colony ◽  
Stimulating Factor

Referat zur Arbeit von McDermott MM, Ferrucci L, Tian L, Guralnik JM, Lloyd-Jones D, Kibbe MR, Polonsky TS, Domanchuk K, Stein JH, Zhao L, Taylor D, Skelly C, Pearce W, Perlman H, McCarthy W, Li L, Gao Y, Sufit R, Bloomfield CL, Criqui MH. Effect of Granulocyte-Macrophage Colony-Stimulating Factor With or Without Supervised Exercise on Walking Performance in Patients With Peripheral Artery Disease. The PROPEL Randomized Clinical Trial JAMA 2017; 318(21): 2089–2098

scholarly journals Promotion of Collateral Growth by Granulocyte-Macrophage Colony-Stimulating Factor in Patients With Coronary Artery Disease

Circulation ◽  
2001 ◽  
Vol 104 (17) ◽  
pp. 2012-2017 ◽  
Author(s):  
Christian Seiler ◽  
Tilmann Pohl ◽  
Kerstin Wustmann ◽  
Damian Hutter ◽  
Pierre-Alain Nicolet ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Colony Stimulating Factor ◽  
Collateral Growth ◽  
Macrophage Colony Stimulating Factor ◽  
Artery Disease ◽  
Macrophage Colony ◽  
Stimulating Factor

Genetic variations of the endothelial nitric oxide synthase gene are related to increased levels of C-reactive protein and macrophage-colony stimulating-factor in patients with coronary artery disease

2006 ◽  
Vol 96 (10) ◽  
pp. 520-528 ◽  
Author(s):  
Ignatios Ikonomidis ◽  
Maria Tsibida ◽  
Athanasios Protogerou ◽  
Aggeliki Papada ◽  
Aggeliki Papapanagiotou ◽  
...  
Keyword(s):  
Colony Stimulating Factor ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Nos3 Gene ◽  
Macrophage Colony Stimulating Factor ◽  
Artery Disease ◽  
Macrophage Colony ◽  
Oxide Synthase ◽  
Intron 4 ◽  
Stimulating Factor

SummaryIt was the objective of this study to investigate the relation between nitric oxide synthase (NOS3) gene polymorphisms, vascular inflammation, endothelial function, and atherosclerosis. We examined the effects of a variable nucleotide tandem repeats (VNTR ) in intron 4, G894T in exon 7 and T-786C at the promoter region of NOS3 on i) C-reactive protein (CRP) and macrophage-colony stimulating-factor (MCSF), and ii) augmentation index (AI) measured by pulse-wave analysis, flow-mediated dilation (FMD) of the brachial artery, intima-media thickness (IMT) of the carotid and femoral artery using ultrasonography and ankle-brachial index (ABI) in 122 patients with chronic coronary artery disease (CAD) who underwent coronary angiography. MCSF and CRP were increased in patients with T-786C (77/122) or VNTR (40/122) allele compared to those without (F=10.8, p=0.002 and F=3.8, p=0.04 for T-786C and F=3.65, p=0.04 and F=3.2 p=0.049 for VNTR), even after adjustment for traditional risk factors and medication. Patients with combination of VNTR and T-786C (31/122) had higher MCSF or CRP than patients with one or none of these alleles (p<0.05). Among patients with T-786C, those with MCSF>262 pg/ml or CRP>3.2 mg/l (n=33/77) had a higher femoral and carotid IMT and number of plaques in the peripheral arteries than those with lower values of these inflammatory indices (p<0.05). Patients with MCSF >262 pg/ml had also lower FMD and higher Gensini score than those with lower MCSF (p<0.05).The intron 4-VNTR and T-786C mutation of NOS3 gene enhance the inflammatory process in patients with chronic CAD.

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