scholarly journals Effect of Granulocyte-Macrophage Colony-Stimulating Factor With or Without Supervised Exercise on Walking Performance in Patients With Peripheral Artery Disease

JAMA ◽  
2017 ◽  
Vol 318 (21) ◽  
pp. 2089 ◽  
Author(s):  
Mary M. McDermott ◽  
Luigi Ferrucci ◽  
Lu Tian ◽  
Jack M. Guralnik ◽  
Donald Lloyd-Jones ◽  
...  
Keyword(s):  
Peripheral Artery Disease ◽  
Colony Stimulating Factor ◽  
Peripheral Artery ◽  
Supervised Exercise ◽  
Walking Performance ◽  
Macrophage Colony Stimulating Factor ◽  
Artery Disease ◽  
Macrophage Colony ◽  
Stimulating Factor

Die Stimulation von Vorläuferzellen des Gefäßendothels zeigt keinen zum Laufbandtraining zusätzlichen Effekt auf die 6-Minuten Gehstrecke

2018 ◽  
Vol 28 (01) ◽  
pp. 4-4
Author(s):  
K. Ammer
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Colony Stimulating Factor ◽  
Peripheral Artery ◽  
Supervised Exercise ◽  
Walking Performance ◽  
Macrophage Colony Stimulating Factor ◽  
Artery Disease ◽  
Macrophage Colony ◽  
Stimulating Factor

Referat zur Arbeit von McDermott MM, Ferrucci L, Tian L, Guralnik JM, Lloyd-Jones D, Kibbe MR, Polonsky TS, Domanchuk K, Stein JH, Zhao L, Taylor D, Skelly C, Pearce W, Perlman H, McCarthy W, Li L, Gao Y, Sufit R, Bloomfield CL, Criqui MH. Effect of Granulocyte-Macrophage Colony-Stimulating Factor With or Without Supervised Exercise on Walking Performance in Patients With Peripheral Artery Disease. The PROPEL Randomized Clinical Trial JAMA 2017; 318(21): 2089–2098

scholarly journals Promotion of Collateral Growth by Granulocyte-Macrophage Colony-Stimulating Factor in Patients With Coronary Artery Disease

Circulation ◽  
2001 ◽  
Vol 104 (17) ◽  
pp. 2012-2017 ◽  
Author(s):  
Christian Seiler ◽  
Tilmann Pohl ◽  
Kerstin Wustmann ◽  
Damian Hutter ◽  
Pierre-Alain Nicolet ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Colony Stimulating Factor ◽  
Collateral Growth ◽  
Macrophage Colony Stimulating Factor ◽  
Artery Disease ◽  
Macrophage Colony ◽  
Stimulating Factor

Abstract 116: Revascularization but Not Supervised Exercise Therapy Prevents Progression of Fibrosis in the Gastrocnemius of Patients With Peripheral Artery Disease While Improving Limb Function

2016 ◽  
Vol 36 (suppl_1) ◽  
Author(s):  
Duy Ha ◽  
George Casale ◽  
Alicia Luis ◽  
Kevin Harkins ◽  
Reagan Huber ◽  
...  
Keyword(s):  
Peripheral Artery Disease ◽  
Exercise Therapy ◽  
Transforming Growth Factor ◽  
Walking Distance ◽  
Peripheral Artery ◽  
Limb Function ◽  
Supervised Exercise ◽  
Walking Performance ◽  
Artery Disease ◽  
Tgf Β1

Introduction: Patients with peripheral artery disease (PAD) develop myofiber degeneration and fibrosis in their ischemic lower extremities, along with limb dysfunction. Walking performance improves with revascularization and exercise therapy, but effects on the myopathy are unknown. We previously showed fibrosis progresses with PAD and positively correlates with expression of vascular transforming growth factor-beta 1 (TGF-β1), a cytokine that stimulates collagen deposition. Hypothesis: We hypothesize that revascularization (RVS) and supervised exercise therapy (EXE) improve limb function in association with improved TGF-β1 dependent fibrosis. Methods: Gastrocnemius biopsies were collected from PAD patients (Fontaine Stage II; N=56) at baseline and 6 months after RVS (N=20), EXE (N=19), or no intervention (CTL; N=17). TGF-β1 expression was measured as grey scale units (gsu) by quantitative fluorescence microscopy of paraffin-embedded gastrocnemius sections. Collagen abundance was measured as optical density by quantitative multi-spectral bright-field microscopy of Masson Trichrome stained paraffin sections. Six Minute Walking Distance (SMWD), in meters, and Peak Walking Time (PWT), in seconds, were determined at baseline and 6 months. Relationships among TGF-β1, collagen, and limb function were assessed. Results: TGF-β1 expression and collagen density increased in CTL and EXE but not RVS patients. SMWD and PWT increased among RVS patients. PWT but not SMWD increased among EXE patients. SMWD and PWT were unchanged among CTL patients. The data are summarized in Table 1. Conclusions: RVS and EXE improved walking performance of patients with PAD, but only RVS prevented progression of fibrosis in the gastrocnemius of these patients. Over the same 6-month period, fibrosis increased in CTL muscle but was not sufficient to alter walking performance. The data suggest that benefits to the PAD leg may be greater with RVS compared to EXE.

Genetic variations of the endothelial nitric oxide synthase gene are related to increased levels of C-reactive protein and macrophage-colony stimulating-factor in patients with coronary artery disease

2006 ◽  
Vol 96 (10) ◽  
pp. 520-528 ◽  
Author(s):  
Ignatios Ikonomidis ◽  
Maria Tsibida ◽  
Athanasios Protogerou ◽  
Aggeliki Papada ◽  
Aggeliki Papapanagiotou ◽  
...  
Keyword(s):  
Colony Stimulating Factor ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Nos3 Gene ◽  
Macrophage Colony Stimulating Factor ◽  
Artery Disease ◽  
Macrophage Colony ◽  
Oxide Synthase ◽  
Intron 4 ◽  
Stimulating Factor

SummaryIt was the objective of this study to investigate the relation between nitric oxide synthase (NOS3) gene polymorphisms, vascular inflammation, endothelial function, and atherosclerosis. We examined the effects of a variable nucleotide tandem repeats (VNTR ) in intron 4, G894T in exon 7 and T-786C at the promoter region of NOS3 on i) C-reactive protein (CRP) and macrophage-colony stimulating-factor (MCSF), and ii) augmentation index (AI) measured by pulse-wave analysis, flow-mediated dilation (FMD) of the brachial artery, intima-media thickness (IMT) of the carotid and femoral artery using ultrasonography and ankle-brachial index (ABI) in 122 patients with chronic coronary artery disease (CAD) who underwent coronary angiography. MCSF and CRP were increased in patients with T-786C (77/122) or VNTR (40/122) allele compared to those without (F=10.8, p=0.002 and F=3.8, p=0.04 for T-786C and F=3.65, p=0.04 and F=3.2 p=0.049 for VNTR), even after adjustment for traditional risk factors and medication. Patients with combination of VNTR and T-786C (31/122) had higher MCSF or CRP than patients with one or none of these alleles (p<0.05). Among patients with T-786C, those with MCSF>262 pg/ml or CRP>3.2 mg/l (n=33/77) had a higher femoral and carotid IMT and number of plaques in the peripheral arteries than those with lower values of these inflammatory indices (p<0.05). Patients with MCSF >262 pg/ml had also lower FMD and higher Gensini score than those with lower MCSF (p<0.05).The intron 4-VNTR and T-786C mutation of NOS3 gene enhance the inflammatory process in patients with chronic CAD.

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