scholarly journals Safety and efficacy of currently utilized treatment modalities in the management of patients with PIK3CA-related overgrowth syndrome - a systematic review

2021 ◽  
Author(s):  
Sarah M. Bernhard ◽  
Luise Adam ◽  
Hady Atef ◽  
Dario Häberli ◽  
Wichor M. Bramer ◽  
...  
Keyword(s):  
Systematic Review ◽  
Treatment Modalities ◽  
Safety And Efficacy ◽  
Overgrowth Syndrome

scholarly journals Safety and Efficacy of Convalescent Plasma Therapy for the Management of COVID-19: A Systematic Review

Coronaviruses ◽  
2020 ◽  
Vol 01 ◽  
Author(s):  
Sitaram Khadka ◽  
Muhammad Saleem ◽  
Dhan Bahadur Shrestha ◽  
Pravash Budhathoki
Keyword(s):  
Systematic Review ◽  
English Language ◽  
Clinical Symptoms ◽  
Therapeutic Option ◽  
Data Extraction ◽  
Treatment Modalities ◽  
Plasma Therapy ◽  
Safety And Efficacy ◽  
Viral Loads ◽  
Rational Practice

Introduction: Till date, no proven therapy exists for coronavirus disease (COVID-19), though different types of treatment modalities are being practiced around the world. Different studies regarding convalescent plasma (CP) therapy from COVID-19 recovered donors have shown favorable results with fewer adverse consequences. In this systematic review, we have aimed to determine the safety and efficacy of CP as a therapy for COVID-19. Methods and Materials: The English language databases of PubMed, Google Scholar, and ScienceDirect were searched up to 22 May 2020. Eligibility for inclusion, risk of bias assessment, and data extraction from the included studies were determined and a narrative synthesis was conducted. Results: A total of 12 studies were selected for review. The overall risks of bias were moderate to high. The results revealed significance in the initiation of CP therapy during the early stages of viremia in a safety and efficacy viewpoint. The patients were also receiving concomitant drugs and other supportive therapies in most cases. Some cases of mortality were reported in 3 studies. Viral loads were documented to decrease and become negative in 8 studies within 3-26 days post-transfusion. The improvement in clinical symptoms following CP therapy was demonstrated in 9 studies. Most of the patients experienced very few adverse effects. Conclusions: The rational practice of CP therapy based on a risk-benefit judgment can prove to be an efficacious therapeutic option as a last resort until the approval of any therapeutic and/or prophylactic agent(s). The substantial randomized controlled trials (RCTs) are necessary to validate the effectiveness of such therapy.

Management of isolated cricopharyngeal dysfunction: systematic review

2016 ◽  
Vol 130 (7) ◽  
pp. 611-615 ◽  
Author(s):  
A Ashman ◽  
O T Dale ◽  
D L Baldwin
Keyword(s):  
Systematic Review ◽  
Qualitative Analysis ◽  
Botulinum Toxin A ◽  
Case Series ◽  
Good Evidence ◽  
Therapeutic Interventions ◽  
Treatment Modalities ◽  
Cochrane Library ◽  
Safety And Efficacy ◽  
Cricopharyngeal Dysfunction

AbstractObjective:A systematic review was performed to evaluate the safety and efficacy of different therapeutic interventions available for the management of isolated cricopharyngeal dysfunction.Methods:Studies were identified using the following databases: Ovid (Medline, Embase), the Cochrane Library, PubMed and Google Scholar. An initial search identified 339 articles. All titles and abstracts were reviewed. Fifty-six relevant articles were inspected in more detail; of these, 47 were included in the qualitative analysis.Results:No relevant randomised trials were found. A range of case series were used to perform a qualitative analysis. Botulinum toxin A injection and cricopharyngeal dilatation were associated with a higher risk of recurrence, but appear to be more suitable in elderly and co-morbid patients. In those patients requiring formal myotomy, endoscopic approaches appear to be as effective but less morbid when compared with classical open surgery.Conclusion:There is good evidence for the safety and efficacy of the different therapeutic options for isolated cricopharyngeal dysfunction. However, further studies are required to compare the efficacy of the various treatment modalities.

Safety and efficacy of UV application for superficial infections in humans: A systematic review and meta-analysis

2021 ◽  
Author(s):  
Sanjay Marasini ◽  
Alexis Ceecee Zhang ◽  
Simon J. Dean ◽  
Simon Swift ◽  
Jennifer P. Craig
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Safety And Efficacy

scholarly journals Splenic Artery Embolisation for the Emergency Treatment of Sinistral Portal Hypertension: A Systematic Review

2021 ◽  
Vol 5 (02) ◽  
pp. 079-085
Author(s):  
Harriet Grout-Smith ◽  
Ozbil Dumenci ◽  
N. Paul Tait ◽  
Ali Alsafi
Keyword(s):  
Systematic Review ◽  
Portal Hypertension ◽  
Variceal Bleeding ◽  
Splenic Artery ◽  
Splenic Vein ◽  
Treatment Modalities ◽  
Portal System ◽  
Technical Success Rate ◽  
Randomized Controlled Studies ◽  
Sinistral Portal Hypertension

Abstract Objectives Sinistral portal hypertension (SPH) is caused by increased pressure on the left portal system secondary to splenic vein stenosis or occlusion and may lead to gastric varices. The definitive management of SPH is splenectomy, but this is associated with significant mortality and morbidity in the acute setting. In this systematic review, we investigated the efficacy and safety of splenic artery embolisation (SAE) in managing refractory variceal bleeding in patients with SPH. Methods A comprehensive literature search was conducted using MEDLINE and Embase databases. A qualitative analysis was chosen due to heterogeneity of the studies. Results Our search yielded 339 articles, 278 of which were unique. After initial screening, 16 articles relevant to our search remained for full text review. Of these, 7 were included in the systematic review. All 7 papers were observational, 6 were retrospective. Between them they described 29 SAE procedures to control variceal bleeding. The technical success rate was 100% and there were no cases of rebleeding during follow up. The most common complication was post-embolisation syndrome. Four major complications occurred, two resulting in death. These deaths were the only 30-day mortalities recorded and were in patients with extensive comorbidities. Conclusions Although there is a distinct lack of randomized controlled studies comparing SAE to other treatment modalities, it appears to be safe and effective in treating hemorrhage secondary to SPH.

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