A multicenter, randomized, placebo-controlled, double-blind phase 3 trial with open-arm comparison indicates safety and efficacy of nephroprotective therapy with ramipril in children with Alport’s syndrome

Oliver Gross; Burkhard Tönshoff; Lutz T. Weber; Lars Pape; Kay Latta; Henry Fehrenbach; Baerbel Lange-Sperandio; Hildegard Zappel; Peter Hoyer; Hagen Staude; Sabine König; Ulrike John; Jutta Gellermann; Bernd Hoppe; Matthias Galiano; Britta Hoecker; Rasmus Ehren; Christian Lerch; Clifford E. Kashtan; Markus Harden; Jan Boeckhaus; Tim Friede; Michael Koziolek; Carsten Paul Bramlage; Frauke Weber; Tanja Albrecht-Nock; Joseph Sonntag; Jenny Frese; Matthias Kettwig; Reinhard Hilgers; Matthias Hansen; Mirja Wedekin; Nicole Meyer; Susanne Klaiber; Michaela Gessner; Max Liebau; Anne-Kristin Vogt-Weigeldt; Therese Jungraithmayr; Sabine Ponsel; Ulrike Jacoby; Martin Konrad; Brigitta Kranz; Jens Koenig; Lisa Loechtermann; Michael Pohl; Ralf Husain; Katrin Mueller; Julia Thumfart; Gesa Schalk; Markus Feldkoetter; Sabine Schmidt; Katja Sauerstein; Evelin Muschiol; Heiko Billing; Frauke Wilkening

doi:10.1016/j.kint.2019.12.015

A multicenter, randomized, placebo-controlled, double-blind phase 3 trial with open-arm comparison indicates safety and efficacy of nephroprotective therapy with ramipril in children with Alport’s syndrome

Kidney International ◽

10.1016/j.kint.2019.12.015 ◽

2020 ◽

Vol 97 (6) ◽

pp. 1275-1286 ◽

Cited By ~ 15

Author(s):

Oliver Gross ◽

Burkhard Tönshoff ◽

Lutz T. Weber ◽

Lars Pape ◽

Kay Latta ◽

...

Keyword(s):

Alport's Syndrome ◽

Phase 3 ◽

Double Blind ◽

Safety And Efficacy ◽

Alport’S Syndrome

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Spine Treatment Appraisal Report (STAR): Does Riluzole Improve Outcomes in Patients Undergoing Decompression Surgery for Degenerative Cervical Myelopathy?

Global Spine Journal ◽

10.1177/2192568221997401 ◽

2021 ◽

pp. 219256822199740

Author(s):

Joseph R. Dettori

Keyword(s):

Cervical Myelopathy ◽

Decompressive Surgery ◽

Decompression Surgery ◽

Phase 3 ◽

Double Blind ◽

Safety And Efficacy ◽

Double Blind Placebo ◽

Degenerative Cervical Myelopathy

Fehlings MG, Badhiwala JH, Ahn H, et al. Safety and efficacy of riluzole in patients undergoing decompressive surgery for degenerative cervical myelopathy (CSM-Protect): a multicentre, double-blind, placebo-controlled, randomised, phase 3 trial. Lancet Neurol. 2020.

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Safety and efficacy of riluzole in patients undergoing decompressive surgery for degenerative cervical myelopathy (CSM-Protect): a multicentre, double-blind, placebo-controlled, randomised, phase 3 trial

The Lancet Neurology ◽

10.1016/s1474-4422(20)30407-5 ◽

2020 ◽

Author(s):

Michael G Fehlings ◽

Jetan H Badhiwala ◽

Henry Ahn ◽

H Francis Farhadi ◽

Christopher I Shaffrey ◽

...

Keyword(s):

Cervical Myelopathy ◽

Decompressive Surgery ◽

Phase 3 ◽

Double Blind ◽

Safety And Efficacy ◽

Double Blind Placebo ◽

Degenerative Cervical Myelopathy

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Safety and efficacy of agomelatine in combination with psychosocial counselling in children and adolescents with major depressive disorder: a double-blind, randomised, controlled, phase 3 trial in nine countries

The Lancet Psychiatry ◽

10.1016/s2215-0366(21)00390-4 ◽

2021 ◽

Author(s):

Celso Arango ◽

Jan K Buitelaar ◽

Jörg M Fegert ◽

Valérie Olivier ◽

Pierre-François Pénélaud ◽

...

Keyword(s):

Major Depressive Disorder ◽

Depressive Disorder ◽

Children And Adolescents ◽

Major Depressive ◽

Phase 3 ◽

Double Blind ◽

Safety And Efficacy ◽

Psychosocial Counselling ◽

Randomised Controlled

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Safety and efficacy of BI 695501 versus adalimumab reference product in patients with advanced Crohn's disease (VOLTAIRE-CD): a multicentre, randomised, double-blind, phase 3 trial

The Lancet Gastroenterology & Hepatology ◽

10.1016/s2468-1253(21)00252-1 ◽

2021 ◽

Author(s):

Stephen Hanauer ◽

Bernd Liedert ◽

Sigrid Balser ◽

Ekkehard Brockstedt ◽

Viktoria Moschetti ◽

...

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Reference Product ◽

Phase 3 ◽

Double Blind ◽

Safety And Efficacy

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Longer-Term Safety and Efficacy of Emtricitabine and Tenofovir Alafenamide Versus Emtricitabine and Tenofovir Disoproxil Fumarate for HIV-1 Pre-Exposure Prophylaxis: Week 96 Results from a Randomized, Double-Blind, Placebo-Controlled Phase 3 Trial

SSRN Electronic Journal ◽

10.2139/ssrn.3772801 ◽

2021 ◽

Author(s):

Onyema Ogbuagu ◽

Peter J. Ruane ◽

Daniel Podzamczer ◽

Laura C. Salazar ◽

Keith Henry ◽

...

Keyword(s):

Tenofovir Disoproxil Fumarate ◽

Phase 3 ◽

Double Blind ◽

Safety And Efficacy ◽

Double Blind Placebo ◽

Tenofovir Alafenamide ◽

Exposure Prophylaxis ◽

Hiv 1

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Safety and efficacy of cipaglucosidase alfa plus miglustat versus alglucosidase alfa plus placebo in late-onset Pompe disease (PROPEL): an international, randomised, double-blind, parallel-group, phase 3 trial

The Lancet Neurology ◽

10.1016/s1474-4422(21)00331-8 ◽

2021 ◽

Vol 20 (12) ◽

pp. 1027-1037 ◽

Cited By ~ 1

Author(s):

Benedikt Schoser ◽

Mark Roberts ◽

Barry J Byrne ◽

Sheela Sitaraman ◽

Hai Jiang ◽

...

Keyword(s):

Pompe Disease ◽

Late Onset ◽

Phase 3 ◽

Double Blind ◽

Safety And Efficacy ◽

Parallel Group ◽

Alglucosidase Alfa

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Safety and efficacy of oral levosimendan in people with amyotrophic lateral sclerosis (the REFALS study): a randomised, double-blind, placebo-controlled phase 3 trial

The Lancet Neurology ◽

10.1016/s1474-4422(21)00242-8 ◽

2021 ◽

Vol 20 (10) ◽

pp. 821-831

Author(s):

Merit Cudkowicz ◽

Angela Genge ◽

Nicholas Maragakis ◽

Susanne Petri ◽

Leonard van den Berg ◽

...

Keyword(s):

Amyotrophic Lateral Sclerosis ◽

Phase 3 ◽

Double Blind ◽

Safety And Efficacy ◽

Double Blind Placebo ◽

Lateral Sclerosis

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Safety and efficacy of oral nemonoxacin versus levofloxacin in treatment of community-acquired pneumonia: A phase 3, multicenter, randomized, double-blind, double-dummy, active-controlled, non-inferiority trial

Journal of Microbiology Immunology and Infection ◽

10.1016/j.jmii.2017.07.011 ◽

2019 ◽

Vol 52 (1) ◽

pp. 35-44 ◽

Cited By ~ 13

Author(s):

Jinyi Yuan ◽

Biwen Mo ◽

Zhuang Ma ◽

Yuan Lv ◽

Shih-Lung Cheng ◽

...

Keyword(s):

Community Acquired Pneumonia ◽

Phase 3 ◽

Double Blind ◽

Safety And Efficacy

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Safety and efficacy of hydrogen peroxide topical solution, 40% (w/w), in patients with seborrheic keratoses: Results from 2 identical, randomized, double-blind, placebo-controlled, phase 3 studies (A-101-SEBK-301/302)

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2018.05.044 ◽

2018 ◽

Vol 79 (5) ◽

pp. 869-877 ◽

Cited By ~ 11

Author(s):

Leslie S. Baumann ◽

Andrew Blauvelt ◽

Zoe D. Draelos ◽

Steven E. Kempers ◽

Mary P. Lupo ◽

...

Keyword(s):

Hydrogen Peroxide ◽

Phase 3 ◽

Double Blind ◽

Safety And Efficacy ◽

Double Blind Placebo ◽

Topical Solution ◽

Seborrheic Keratoses

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Safety and efficacy of elobixibat for chronic constipation: results from a randomised, double-blind, placebo-controlled, phase 3 trial and an open-label, single-arm, phase 3 trial

The Lancet Gastroenterology & Hepatology ◽

10.1016/s2468-1253(18)30123-7 ◽

2018 ◽

Vol 3 (8) ◽

pp. 537-547 ◽

Cited By ~ 41

Author(s):

Atsushi Nakajima ◽

Mitsunori Seki ◽

Shinya Taniguchi ◽

Akira Ohta ◽

Per-Göran Gillberg ◽

...

Keyword(s):

Chronic Constipation ◽

Open Label ◽

Phase 3 ◽

Double Blind ◽

Safety And Efficacy ◽

Double Blind Placebo

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