Expression of transforming growth factor beta (TGF-b1) by human preterm lung inflammatory cells

Background: Radiographic examination is often used in dentistry to evaluate tooth extraction complications. X-ray used in radiographic examination, however, has negative effects, including damage to DNA and inflammatory response during wound healing process. Purpose: This study aimed to analyze the effects of X-ray irradiation on transforming growth factor beta 1 (TGF-ß1) expression and number of inflammatory cells in tooth extraction sockets. Method: Thirty rats were divided into three groups, which consist of control group (with a radiation of 0 mSv), treatment group 1 (with a radiation of 0.08 mSv), and treatment group 2 (with a radiation of 0.16 mSv). These rats in each group were sacrificed on days 3 and 5 after treatment. Inflammatory cells which were observed in this research were PMN, macrophages, and lymphocytes. Histopathological and immunohistochemical examinations were used to calculate the number of inflammatory cells and TGF-ß1 expression. Obtained data were analyzed using SPSS 16.0 software with one way ANOVA and Tukey’s HSD tests. Result: There was no significant decrease in the number of PMN. On the other hand, there were significant decreases in the number of macrophages and lymphocytes in the sacrificed group on day-5 with the radiation of 0.16 mSv. Similarly, the most significant decreased expression of TGF-ß1 was found in the group sacrificed on day 5 with the radiation of 0.16 mSv. Conclusion: X-ray irradiation with 0.08 mSv and 0.16 mSv doses can decrease TGF-ß1 expression and number of inflammatory cells in tooth extraction sockets on day 3 and 5 post extraction.

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Transforming growth factor beta expression in reactive spinal cord microglia and meningeal inflammatory cells during experimental allergic neuritis

Journal of Neuroscience Research ◽

10.1002/jnr.490360405 ◽

1993 ◽

Vol 36 (4) ◽

pp. 391-398 ◽

Cited By ~ 40

Author(s):

R. Kiefer ◽

R. Gold ◽

J. Gehrmann ◽

D. Lindholm ◽

H. Wekerle ◽

...

Keyword(s):

Spinal Cord ◽

Growth Factor ◽

Transforming Growth Factor Beta ◽

Transforming Growth Factor ◽

Inflammatory Cells ◽

Experimental Allergic Neuritis ◽

Growth Factor Beta ◽

Experimental Allergic ◽

Allergic Neuritis

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Hypertrophy of the ligamentum flavum and expression of transforming growth factor beta

Journal of International Medical Research ◽

10.1177/0300060517711308 ◽

2017 ◽

Vol 45 (6) ◽

pp. 2036-2041 ◽

Cited By ~ 2

Author(s):

Aierken Amudong ◽

Aikeremujiang Muheremu ◽

Tuerhongjiang Abudourexiti

Keyword(s):

Growth Factor ◽

Transforming Growth Factor Beta ◽

Transforming Growth Factor ◽

Ligamentum Flavum ◽

Inflammatory Cells ◽

Lumbar Region ◽

Cellular Apoptosis ◽

Growth Factor Beta ◽

Immunohistochemical Studies ◽

Lumbar Spinal

Objective To explore the relationship between cellular apoptosis and hypertrophy of the ligamentum flavum in the lumbar region. Methods Thirty patients with lumbar spinal stenosis were evaluated. Hypertrophy of the ligamentum flavum was present in 15 patients and absent in 15. Hematoxylin–eosin staining and transforming growth factor beta (TGF-β) immunohistochemical testing were applied to compare these two groups. Results Derangement of fibrous alignment, fibrocartilage changes, and infiltration of inflammatory cells were observed in the patients with hypertrophy of the ligamentum flavum, while fibrous alignment was normal and few inflammatory cells were observed in patients without hypertrophy. Immunohistochemical studies showed positive expression of TGF-β in patients with hypertrophy, while expression was negative in patients without hypertrophy. The integrated optical density was 2.6556708 in the hypertrophy group and 23104671 in the normal controls. Conclusions Expression of TGF-β was closely related to hypertrophy of the ligamentum flavum. Appropriate application of the TGF-β expression level can be used to predict progression of hypertrophy of the ligamentum flavum.

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