Association of signal transducer and activator of transcription 4 genetic variants with extra-intestinal manifestations in inflammatory bowel disease

Life Sciences ◽  
2010 ◽  
Vol 86 (17-18) ◽  
pp. 661-667 ◽  
Author(s):  
Chang Mo Moon ◽  
Jae Hee Cheon ◽  
Seung Won Kim ◽  
Dong-Jik Shin ◽  
Eun Soo Kim ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Genetic Variants ◽  
Signal Transducer ◽  
Inflammatory Bowel

scholarly journals Signal transducer and activator of transcription 6 gene G2964A polymorphism and inflammatory bowel disease

2003 ◽  
Vol 131 (3) ◽  
pp. 446-450 ◽  
Author(s):  
B. XIA ◽  
J. B. A. CRUSIUS ◽  
J. WU ◽  
A. ZWIERS ◽  
A. A. VAN BODEGRAVEN ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Signal Transducer ◽  
Inflammatory Bowel

Genetic variants in TNF-α but not DLG5 are associated with inflammatory bowel disease in a large United Kingdom cohort

2006 ◽  
Vol 12 (3) ◽  
pp. 178-184 ◽  
Author(s):  
Mark Tremelling ◽  
Sarah Waller ◽  
Francesca Bredin ◽  
Simon Greenfield ◽  
Miles Parkes
Keyword(s):  
Inflammatory Bowel Disease ◽  
United Kingdom ◽  
Bowel Disease ◽  
Genetic Variants ◽  
Tnf Α ◽  
Inflammatory Bowel

scholarly journals Analysis of Inflammatory Bowel Disease-Associated Genetic Variants in a Healthy Manitoban First Nations Cohort

2011 ◽  
Vol 140 (5) ◽  
pp. S-270
Author(s):  
Travis B. Murdoch ◽  
Charles N. Bernstein ◽  
Hani El-Gabalawy ◽  
Saad Pathan ◽  
Joanne M. Stempak ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
First Nations ◽  
Bowel Disease ◽  
Genetic Variants ◽  
Inflammatory Bowel

124 Exome Analyses Identify Novel Inflammatory Bowel Disease-Associated Genetic Variants

2014 ◽  
Vol 146 (5) ◽  
pp. S-35
Author(s):  
Dalin Li ◽  
Jean-Paul Achkar ◽  
Talin Haritunians ◽  
Ken Hui ◽  
Steven R. Brant ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Genetic Variants ◽  
Inflammatory Bowel

scholarly journals The Impact of PPARγGenetic Variants on IBD Susceptibility and IBD Disease Course

PPAR Research ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Jessica Mwinyi ◽  
Christa Grete-Wenger ◽  
Jyrki J. Eloranta ◽  
Gerd A. Kullak-Ublick
Keyword(s):  
Inflammatory Bowel Disease ◽  
Immune Responses ◽  
Bowel Disease ◽  
Genetic Variants ◽  
Bioinformatic Analysis ◽  
Healthy Controls ◽  
Disease Course ◽  
Colon Inflammation ◽  
Inflammatory Bowel ◽  
The Impact

PPARγ is a nuclear receptor that regulates numerous pathways including cytokine expression and immune responses and plays an important role in controlling colon inflammation. We aimed at determining the occurringPPARγ SNPs, at predicting the haplotypes, and at determining the frequency outcome in inflammatory bowel disease (IBD) patients in comparison with healthy controls. We determined genetic variants in the coding exons and flanking intronic sequences of theNR1C3gene in 284 IBD patients and 194 controls and predictedNR1C3haplotypes via bioinformatic analysis. We investigated whether certainNR1C3variants are associated with susceptibility to IBD or its disease course. None of the detected 22NR1C3variants were associated with IBD. Two variants with allelic frequencies over 1% were included in haplotype/diplotype analyses. None of theNR3C1haplotypes showed association with IBD development or disease course. We conclude thatNR1C3haplotypes are not related to IBD susceptibility or IBD disease activity.

Genome-Wide Search Identified Genetic Variants that can Predict TNF Antagonist Responsiveness in Inflammatory Bowel Disease Patients

2017 ◽  
Vol 152 (5) ◽  
pp. S78-S79
Author(s):  
Ming-Hsi Wang ◽  
Parakkal Deepak ◽  
Jessica Friton ◽  
Laura H. Raffals ◽  
Jonathan A. Leighton ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Genetic Variants ◽  
Genome Wide ◽  
Tnf Antagonist ◽  
Genome Wide Search ◽  
Inflammatory Bowel
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