scholarly journals Endothelin-1 overexpression and endothelial nitric oxide synthase knock-out induce different pathological responses in the heart of male and female mice

Life Sciences ◽  
2014 ◽  
Vol 118 (2) ◽  
pp. 219-225 ◽  
Author(s):  
Nicolas Vignon-Zellweger ◽  
Katharina Relle ◽  
Jan Rahnenführer ◽  
Karima Schwab ◽  
Berthold Hocher ◽  
...  

Life Sciences ◽  
2013 ◽  
Vol 93 (25-26) ◽  
pp. e13
Author(s):  
Nicolas Vignon-Zellweger ◽  
Katharina Relle ◽  
Jan Rahnenfuhrer ◽  
Karima Schwab ◽  
Berthold Hocher ◽  
...  




2008 ◽  
Vol 2008 ◽  
pp. 1-5 ◽  
Author(s):  
J. George Groeneweg ◽  
Claudia Heijmans Antonissen ◽  
Frank J. P. M. Huygen ◽  
Freek J. Zijlstra

Background and Objectives. Impaired microcirculation during the chronic stage of complex regional pain syndrome (CRPS) is related to increased vasoconstriction, tissue hypoxia, and metabolic tissue acidosis in the affected limb. Endothelial dysfunction is suggested to be the main cause of diminished blood flow. The aim of this study was to examine the distribution of endothelial nitric oxide synthase (eNOS) and endothelin-1(ET-1) relative to vascular density represented by the endothelial marker CD31-immunoreactivity in the skin tissue of patients with chronic CRPS.Methods. We performed immunohistochemical staining on sections of skin specimens obtained from the amputated limbs (one arm and one leg) of two patients with CRPS.Results. In comparison to proximal specimens we found an increased number of migrated endothelial cells as well as an increase of eNOS activity in distal dermis specimens.Conclusions. We found indications that endothelial dysfunction plays a role in chronic CRPS.



2014 ◽  
Vol 8 ◽  
pp. GRSB.S14836 ◽  
Author(s):  
Tanya J. Thakur ◽  
Aldiouma Guindo ◽  
Londyn R. Cullifer ◽  
Yi Li ◽  
Ikhide G. Imumorin ◽  
...  


Sign in / Sign up

Export Citation Format

Share Document