sSema4D levels are increased in coronary heart disease and associated with the extent of coronary artery stenosis

Life Sciences ◽  
2019 ◽  
Vol 219 ◽  
pp. 329-335 ◽  
Author(s):  
Hui Gong ◽  
Xing Lyu ◽  
Shizhen Li ◽  
Ruohong Chen ◽  
Min Hu ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Artery ◽  
Coronary Artery Stenosis ◽  
Artery Stenosis

Abstract 268: The Increased Visceral Fat Thickness In Nafld Patients Enhances The Risk Of Coronary Artery Stenosis

Hypertension ◽  
2014 ◽  
Vol 64 (suppl_1) ◽  
Author(s):  
PENG Y CAO ◽  
HE CAI ◽  
MIN LIU ◽  
XIN Y ZHANG ◽  
SHUI YU ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Artery ◽  
Visceral Fat ◽  
Coronary Artery Stenosis ◽  
Artery Stenosis ◽  
Severe Stenosis ◽  
Severe Coronary Artery ◽  
Fat Thickness ◽  
The Relationship

Background: Non alcoholic fatty liver disease (NAFLD) is an independent risk factor of cardiovascular disease (CVD). In this research, we want exploring the relationship between NAFLD, visceral fat thickness and the severity of coronary artery disease. Methods: 1, The relationship between NAFLD, visceral fat thickness and severity of coronary heart disease(323 people). 2, The correlation between severe NAFLD and visceral fat thickness in the severe stenosis of coronary heart disease(197 people). Results: 1, the proportion of NAFLD was significantly increased by 16% and 19% in different coronary artery stenosis than in the normal group. Along with the increasing degree of coronary artery stenosis, the total visceral fat thickness increase, especially the epicardial layer (the moderate stenosis increased by 23% and the severe stenosis increased by 54% than without stenosis). 2, In the severe coronary artery stenosis group, the patients were divided into NAFLD group and non NAFLD group. compared to non NAFLD group, the epicardial, liver, renal, before the perirenal fat and the coronary score significantly increased in the NAFLD group (10%, 22%, 32%, 36% and 27%, respectively) .Along with the increase of coronary score , the epicardial fat thickness was increased significantly (16% and 34%, respectively) in the non NAFLD group; but the epicardial thickness of the NAFLD group was slightly increased (8% and 8%, respectively), there was no significant difference among the subgroups. Furthermore,not only in NAFLD group but also in non NAFLD group, the visceral fat thickness of the other three sections have no significant change among the three subgroups. Conclusion: Both the NAFLD and the epicardial adipose layer thickening can increase the risk of coronary artery stenosis. In the patients with the severe coronary artery stenosis, the NAFLD patients are more likely to increase the accumulation of the visceral fat thickness than the non NAFLD patients. Under the same thickness of the epicardium, the degree of coronary artery lesions is lighter in the NAFLD patients; it may be related to AMPK wich may have the myocardial protective effects.

scholarly journals Ophthalmological monitoring in patients with hypertension and coronary heart disease

2021 ◽  
Vol 21 (2) ◽  
pp. 51-57
Author(s):  
L.K. Moshetova ◽  
◽  
I.V. Vorobyeva ◽  
A. Dgebuadze ◽  
O.D. Ostroumova ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Artery ◽  
Coronary Artery Stenosis ◽  
Artery Stenosis ◽  
Foveal Avascular Zone ◽  
Avascular Zone ◽  
Capillary Plexus ◽  
Group A ◽  
Group B

Aim: to study ophthalmological clinical functional parameters in patients with hypertension and coronary heart disease (CHD) with coronary artery stenosis. Patients and Methods: 30 patients (58 eyes) with hypertension and CHD with coronary artery stenosis (group A) and 30 healthy controls (60 eyes, group B) were examined. Best-corrected visual acuity (BCVA), macular sensitivity (MS) assessed by MAIA microperimetry, central macular thickness (CMT), foveal avascular zone (FAZ) area, vessel density of superficial capillary plexus (SCP VD) and deep capillary plexus (DCP VD) and choriocapillaris measured by optical coherence tomography angiography (OCTA) were evaluated. Results: FAZ area was 0.42±0.03 mm2 in group A and 0.28±0.03 mm2 in group B (p<0.05). SCP VD was 11.4±3.1% in group A and 25.4±2.5% in group B (p<0.05). DCP VD was 22.3±1.1% in group A and 39.2±3.5% in group B (p<0.05). Choriocapillaris VD was 51.2±1.1% in group A and 63.1±1.2% in group B (p<0.05). Correlations between ocular parameters and ejection fraction (EF) were revealed (BCVA: r=0.61, p<0.05; MS: r=0.68, p<0.05; CMT: r=-0.72, p<0.05; FAZ: r=-0.73, p<0.05; SCP VD: r=0.82, p<0.05; DCP VD: r=0.81, p<0.05; choriocapillaris VD: r=0.76, p<0.05). Conclusions: in patients with hypertension and CHD with coronary artery stenosis, significant (p<0.05) reduction in BCVA, MS, SCP VD, DCP VD, and choriocapillaris VD and increase in CMT and FAZ area were detected compared to healthy individuals. Additionally, strong correlations between ocular parameters (FAZ, SCP VD, DCP VD, and choriocapillaris VD) and EF (p<0.05) were identified. OCTA may be recommended to monitor fundus vessels in hypertension and CHD as an effective noninvasive valuable diagnostic tool to verify hypertension and CHD. Keywords: hypertension, coronary heart disease, coronary artery stenosis, hypertensive retinopathy, foveal avascular zone, vessel density, optical coherence tomography angiography. For citation: Moshetova L.K., Vorobyeva I.V., Dgebuadze A. et al. Ophthalmological monitoring in patients with hypertension and coronary heart disease. Russian Journal of Clinical Ophthalmology. 2021;21(2):51–57. DOI: 10.32364/2311-7729-2021-21-2-51-57.

scholarly journals Correlation between Blood Pressure and Severity of Atherosclerosis in The Left Main Coronary Artery with CT Coronary Angiography Examination

2017 ◽  
Vol 3 (1) ◽  
pp. 23
Author(s):  
Esis Prasasti Inda Chaula ◽  
Nurdopo Baskoro
Keyword(s):  
Blood Pressure ◽  
Coronary Heart Disease ◽  
Coronary Artery ◽  
Systolic Blood Pressure ◽  
Left Main Coronary Artery ◽  
Coronary Artery Stenosis ◽  
Artery Stenosis ◽  
P Value ◽  
Left Main ◽  
Main Coronary Artery Stenosis

Background: Cardiovascular disease, especially hypertension, is the main cause of death in both developed and developing countries. Hypertensioncan lead to atherosclerosis, which is the most common cause of ischemic and coronary heart disease. Some countries have used Computed Tomography Coronary Angiography (CTCA), which is a noninvasive test, to observe the anatomy of coronary artery. Nevertheless, invasive angiography isstill the gold standardfor coronary artery visualization. Atherosclerotic plaques cancause left main coronary artery stenosis. Purpose: The purpose of this research is to analyze the correlation between blood pressure and severity of the atherosclerosis in the left main coronary artery. With CTCA examination, the presence of plaque, severity of stenosis and type of plaques were assessed. Methods: The study design was analytic observational with cross sectional design. Data was drawn from medical records. The sample included a total of 29 patients which were suspected of having coronary heart disease and examined with CTCA who meet inclusion and exclusion criteria in Dr. Kariadi Hospital, Semarang, Indonesia. Result: The correlation between systolic blood pressure and left main coronary artery stenosis was obtained by Spearman’s rho r = 0.0429, p-value of with of 0.020 (2-tailed). The correlation between diastolic blood pressure and left main coronary artery stenosis was obtained by Spearman’s rho r = 0.354 with p-value of 0.060(2 -tailed). Some types of plaques were found in left main coronary artery, and systolic blood pressure are significantly different analysed usingAnova (analysis of variance) which probability was significant with p value 0.041. Conclusion: There was a significant correlation between systolic blood pressure and left main coronary artery stenosis. Therewas no correlation between diastolic blood pressure and left main coronary artery stenosis. Furthermore, there was a significant difference between systolic blood pressure and the type of plaques in the left main coronary artery. 

scholarly journals Diagnostic Test Squatting Stress Echocardiography and Coronary Angiography in Diagnosing Coronary Heart Disease

2017 ◽  
pp. 190-8
Author(s):  
Andy Rahman ◽  
Mefri Yanni ◽  
Masrul Syafri
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Artery ◽  
Coronary Angiography ◽  
Unstable Angina ◽  
Predictive Value ◽  
Stress Echocardiography ◽  
Coronary Artery Stenosis ◽  
Non Invasive ◽  
Sensitivity Specificity

Background: In patients with significant coronary heart disease (CHD), increased preload and afterload during a squat can cause wall motion abnormalities (WMA) which can be detected on echocardiography. This study was conducted to determine the diagnostic value of stress echocardiography squatting as a non-invasive examination of a relatively simple, inexpensive, and safe in the detection of coronary artery stenosis in stable CHD and unstable angina patients.Methods: This study was a cross-sectional design. The subjects were all patients with stable CHD and unstable angina whom were treated in Instalasi Pusat Jantung Rumah Sakit Dr. M. Djamil Padang from May to July 2016. Subjects underwent squatting stress echocardiography procedures followed by coronary angiography. Diagnostic test was used to determine the sensitivity, specificity, positive predictive value, negative predictive value and accuracy of squatting stress echocardiography.Results: The sensitivity, specificity, and accuracy of squatting echocardiography for diagnosis of CAD were 90.3%, 88.9% and 89.7%, respectively.Conclusion: Squatting stress echocardiography can be proposed as a non-invasive examination which is relatively simple, inexpensive and safe to detect coronary artery stenosis on patients with stable CHD and unstable CHD.

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