Neuroprotective effects of increasing levels of HSP70 against neuroinflammation in Parkinson's disease model by inhibition of NF-κB and STAT3

Life Sciences ◽  
2019 ◽  
Vol 234 ◽  
pp. 116747 ◽  
Author(s):  
Haining Li ◽  
Juan Yang ◽  
Yanbai Wang ◽  
Qiang Liu ◽  
Jiang Cheng ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Model ◽  
Neuroprotective Effects

scholarly journals Exercise exerts neuroprotective effects on Parkinson's disease model of rats

2010 ◽  
Vol 1310 ◽  
pp. 200-207 ◽  
Author(s):  
Naoki Tajiri ◽  
Takao Yasuhara ◽  
Tetsuro Shingo ◽  
Akihiko Kondo ◽  
Wenji Yuan ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Model ◽  
Neuroprotective Effects

Neuroprotective effects of ginkgetin against neuroinjury in Parkinson's disease model induced by MPTP via chelating iron

2015 ◽  
Vol 49 (9) ◽  
pp. 1069-1080 ◽  
Author(s):  
Y.-Q. Wang ◽  
M.-Y. Wang ◽  
X.-R. Fu ◽  
Peng-Yu ◽  
G.-F. Gao ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Model ◽  
Neuroprotective Effects

scholarly journals Neuroprotective Effects of Bak Foong Pill in 1-Methyl-4-phenyl-1,2,3,6-tetrahyrdropyridine (MPTP)-Induced Parkinson's Disease Model Mice

2004 ◽  
Vol 27 (8) ◽  
pp. 1245-1250 ◽  
Author(s):  
Bin Liu ◽  
Jun Xia Xie ◽  
Dewi Kenneth Rowlands ◽  
Yu Lin Gou ◽  
Ching Cheong Leung ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Model ◽  
Neuroprotective Effects

scholarly journals Gastrodin Protects Apoptotic Dopaminergic Neurons in a Toxin-Induced Parkinson’s Disease Model

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Hemant Kumar ◽  
In-Su Kim ◽  
Sandeep Vasant More ◽  
Byung-Wook Kim ◽  
Young-Yil Bahk ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dopaminergic Neurons ◽  
Disease Model ◽  
Motor Impairment ◽  
Protective Effects ◽  
Dopamine Depletion ◽  
Active Constituent ◽  
Neuroprotective Effects ◽  
Phenolic Glucoside

Gastrodia elata(GE) Blume is one of the most important traditional plants in Oriental countries and has been used for centuries to improve various conditions. The phenolic glucoside gastrodin is an active constituent of GE. The aim of this study was to investigate the neuroprotective role of gastrodin in 1-methyl-4-phenylpyridinium (MPP+)/1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- (MPTP) induced human dopaminergic SH-SY5Y cells and mouse model of Parkinson’s disease (PD), respectively. Gastrodin significantly and dose dependently protected dopaminergic neurons against neurotoxicity through regulating free radicals, Bax/Bcl-2 mRNA, caspase-3, and cleaved poly(ADP-ribose) polymerase (PARP) in SH-SY5Y cells stressed with MPP+. Gastrodin also showed neuroprotective effects in the subchronic MPTP mouse PD model by ameliorating bradykinesia and motor impairment in the pole and rotarod tests, respectively. Consistent with this finding, gastrodin prevented dopamine depletion and reduced reactive astrogliosis caused by MPTP as assessed by immunohistochemistry and immunoblotting in the substantiae nigrae and striatata of mice. Moreover, gastrodin was also effective in preventing neuronal apoptosis by attenuating antioxidant and antiapoptotic activities in these brain areas. These results strongly suggest that gastrodin has protective effects in experimental PD models and that it may be developed as a clinical candidate to ameliorate PD symptoms.

Neuroprotective effects of MHY908, a PPAR α/γ dual agonist, in a MPTP-induced Parkinson’s disease model

2019 ◽  
Vol 1704 ◽  
pp. 47-58 ◽  
Author(s):  
Yujeong Lee ◽  
Jung-Hyun Cho ◽  
Seulah Lee ◽  
Wonjong Lee ◽  
Seung-Cheol Chang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Model ◽  
Neuroprotective Effects ◽  
Dual Agonist

scholarly journals Neuroprotective Properties of a Standardized Extract fromMyracrodruon urundeuvaFr. All. (Aroeira-Do-Sertão), as Evaluated by a Parkinson’s Disease Model in Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Iana Calou ◽  
Mary Anne Bandeira ◽  
Wellida Aguiar-Galvão ◽  
Gilberto Cerqueira ◽  
Rafaelly Siqueira ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Folk Medicine ◽  
Disease Model ◽  
Stem Bark ◽  
Semiarid Region ◽  
Behavioral Alterations ◽  
Medicinal Species ◽  
Neuroprotective Effects ◽  
Brazilian Semiarid

Myracrodruon urundeuvaFr. All. (Anacardiaceae) is a Brazilian medicinal species, which is common to the Northeastern Brazilian semiarid region, whose stem-bark is widely used in folk medicine. It is an endangered species, presenting as main bioactive components tannins and chalcones. In this work, we studied the neuroprotective effects of a standardized extract from cultivatedM. urundeuva(SEMU), in a model of Parkinson’s disease. Thus, a unilateral injection of 6-OHDA was done into the rat right stratum. The animals were submitted to stereotaxic surgery, then treated with SEMU (5, 10, 20, or 40 mg/kg, p.o.) for 2 weeks, subjected to behavioral tests, and euthanized for striata dissections and neurochemical, histological, and immunohistochemical analyses. We showed, for the first time, that SEMU reverted behavioral alterations seen in the 6-OHDA-lesioned group and partially blocked the decrease in DA and DOPAC contents. The numbers of viable neurons and TH immunopositive cells were increased by SEMU. In addition, the SEMU-treated 6-OHDA groups showed lower numbers of GFAP and OX-42 immunopositive cells. The neuroprotective action of SEMU is possibly related to the antioxidant and anti-inflammatory properties ofM. urundeuva, pointing out to its potential use in the prevention or treatment of neurodegenerative conditions, such as Parkinson’s disease.

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