Drug abuse during pregnancy and its neonatal impact. Analysis of the periods 2002–2008 and 2009–2017

Drug abuse during pregnancy is a growing problem in all developed countries all over the world. The drugs easily cross the placental barrier into the fetal body and are present also in the maternal milk. Therefore, it may affect the development of the child pre- as well as postnatally. The effects of prenatal drug exposure are long-lasting and persist until adulthood. The present review summarizes the clinical and experimental evidence showing how opioids and psychostimulants can affect maternal behavior of drug-abusing mother and the development of their offspring.

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Drug abuse during pregnancy

Current Opinion in Anaesthesiology ◽

10.1097/00001503-198906000-00009 ◽

1989 ◽

Vol 2 (3) ◽

pp. 311-313???314

Author(s):

A. C. Santos

Keyword(s):

Drug Abuse ◽

Abuse During Pregnancy

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Drug abuse during pregnancy in an inner-city hospital: Prevalence and patterns

The Journal of the American Osteopathic Association ◽

10.1515/jom-1990-900512 ◽

1990 ◽

Vol 90 (5) ◽

pp. 421-426

Author(s):

David B. Land ◽

Roger Kushner

Keyword(s):

Drug Abuse ◽

Inner City ◽

City Hospital ◽

Abuse During Pregnancy

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The effects of prenatal morphine exposure on pain response

European Psychiatry ◽

10.1016/s0924-9338(11)72694-3 ◽

2011 ◽

Vol 26 (S2) ◽

pp. 989-989

Author(s):

M. Amini ◽

A. Alijarahi

Keyword(s):

Drug Abuse ◽

Developed Countries ◽

Female Rats ◽

Pain Response ◽

Long Term Effects ◽

Endogenous Opioid ◽

Pregnant Rats ◽

Lower Pain ◽

Abuse During Pregnancy ◽

And Control

BackgroundDrug abuse during pregnancy is a growing problem in all developed countries of the world. Maternal drug abuse affects the developing system and its long-term effects can persist till adulthood so it can decreases the rate of their maturation. Since endogenous opioid induced analgesia, and morphine can interact with it, Thus the present study was designed to determine whether the exposure to the morphine during gestation permanently alter pain response.ObjectiveTo determine the effects of prenatal morphine exposure on pain responseMaterials and methods12 Pregnant rats were divided to morphine and control groups.Morphine was administrated (S.C) to female rats twice a day (08 h and 20 h) on gestational days 11–18, (5 mg/kg morphine for 3 days and 10 mg/kg for 5 days). Analgesic response of pups (P90, n = 6) were tested by formaline test.FindingThe results of our experiment demonstrated that prenatal morphine exposure rats exhibited significantly lower pain thersholds.ConclusionPrenatal morphine exposure impair pain sensitivity

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Smoking and Drug Abuse During Pregnancy

Obstetrics and Gynecology ◽

10.5005/jp/books/12499_3 ◽

2014 ◽

pp. 5-5

Author(s):

Richa Saxena

Keyword(s):

Drug Abuse ◽

Abuse During Pregnancy

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Determination of methamphetamine in neonatal hair and meconium samples: estimation of fetal drug abuse during pregnancy

Forensic Toxicology ◽

10.1007/s11419-011-0129-y ◽

2012 ◽

Vol 30 (1) ◽

pp. 80-83 ◽

Cited By ~ 7

Author(s):

Mitsuhiro Wada ◽

Yuki Sugimoto ◽

Rie Ikeda ◽

Kazutomo Isono ◽

Naotaka Kuroda ◽

...

Keyword(s):

Drug Abuse ◽

Abuse During Pregnancy

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Diabetes mellitus and drug abuse during pregnancy and the risk for orofacial clefts and related abnormalities

Revista Latino-Americana de Enfermagem ◽

10.1590/1518-8345.0815.2701 ◽

2016 ◽

Vol 24 (0) ◽

Cited By ~ 2

Author(s):

Ivy Kiemle Trindade-Suedam ◽

Lília Maria von Kostrisch ◽

Luiz André Freire Pimenta ◽

Carlos Antônio Negrato ◽

Solange Braga Franzolin ◽

...

Keyword(s):

Diabetes Mellitus ◽

Drug Abuse ◽

Craniofacial Anomalies ◽

Orofacial Clefts ◽

Type 2 Dm ◽

Abuse During Pregnancy ◽

Type 1 Dm ◽

Prevalence Of Diabetes Mellitus

Abstract Objective: to assessed the prevalence of diabetes mellitus (DM) and drug abuse in mothers of children with orofacial clefts (OFC). Methods: 325 women who had children (0-3y) with clefts were interviewed. Data regarding type of diabetes, use of legal/illegal drugs during pregnancy, waist girth and fasting blood sugar at the first prenatal consult were collected. Results: twenty seven percent of the women had DM, out of these, 89% had gestational DM, 5,5% type 1 DM and 5,5% type 2 DM. The prevalence of DM in mothers of children with OFC was 27%, it is significantly higher than the average Brazilian population which is 7.6% (p<0.01) (OR=4.5, 95%CI=3.5-5.8). Regarding drug abuse during pregnancy, 32% of the mothers used drugs and a significant positive correlation was observed between drug abuse and the occurrence of clefts and other craniofacial anomalies (p=0.028) (OR=2.87; 95%CI=1.1-7.4). Conclusions: DM and drug abuse during pregnancy increases the risk for OFC and related anomalies and early diagnosis of DM and prevention of drug abuse, especially in pregnant women, should be emphasized.

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